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240 (0,067s) •

Project

Disturbances of synthesis of cholesterol and its depletion - clinical consequences and opportunities of terapeutical influence in intensive care (NR8921)

of serious hypocholesterolaemias on the source of cholesterol, impact on adrenal function on cholesterol supply in critical disease, a human organism can be deprived of cholesterol are on cholesterol - deficient n...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2006 - 2008
    • •
  • 1 742 tis. Kč
    • •
  • 1 642 tis. Kč
    • •
  • MZ
Project

Alterations of δ-opioid receptor mobility and function by acute and chronic depletion of plasma membrane cholesterol content of live cells (GA17-05903S)

Detailed analysis of the effect of acute and chronic depletion of cell cholesterol level on δ-opioid receptor mobility and function in plasma membrane of model cell lines. For this aim, HEK293 and NG108-15 cells transiently expressi...

CE - Biochemie

  • 2017 - 2019
    • •
  • 6 619 tis. Kč
    • •
  • 6 199 tis. Kč
    • •
  • GA ČR
Project

Comparison of effects of amyloid beta peptide 1-40 and 1-42 on hemicholinium-3 sensitive choline carriers and influence of cholesterol (GA305/03/1547)

and 1 -42 on synaptosomes with altered cholesterol content (depletionRecent research suggests associations between brain cholesterol distribution and Alzheimer disease but a precise role of cholesterol is not full...

FH - Neurologie, neurochirurgie, neurovědy

  • 2003 - 2005
    • •
  • 1 404 tis. Kč
    • •
  • 1 404 tis. Kč
    • •
  • GA ČR
Project

The effect of cell membrane fluidity on the functional properties of NMDA receptors (GPP303/11/P391)

of cholesterol contents in plasma membrane of neurons has neuroprotective effect against NMDA on the relation of cholesterol and NMDA receptors. The main objective is to describe and quantify the effect of membrane cholesterol<...

ED - Fyziologie

  • 2011 - 2015
    • •
  • 2 195 tis. Kč
    • •
  • 2 195 tis. Kč
    • •
  • GA ČR
Project

Nutrition changes and reverse cholesterol transport (NR8486)

Methods for eflux of cholesterol from cell membrane determination will be introduced and otpimized. Reverse cholesterol transport (RTC) will be measured with this method in 3 nutritional situations in which simple determination of H...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2005 - 2008
    • •
  • 3 086 tis. Kč
    • •
  • 2 748 tis. Kč
    • •
  • MZ
Project

The role of DISP3 protein in lipid metabolism (GAP301/12/1478)

In the body the brain is the most cholesterol rich organ. Despite this, remarkably little is known about the mechanisms in the brain that regulate cholesterol and was further found to co-localize with cholesterol. Ectopic e...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2012 - 2017
    • •
  • 7 448 tis. Kč
    • •
  • 7 448 tis. Kč
    • •
  • GA ČR
Project

Development of fluorescent probes for determination of content, localization and trafficking of cholesterol within eukaryotic cells (GA17-02836S)

Although, cholesterol is the molecules of the life essential biological processes, the capability of known molecular tools for detection of cholesterol content of the molecular recognition of cholesterol. New filipin deriva...

CB - Analytická chemie, separace

  • 2017 - 2021
    • •
  • 6 684 tis. Kč
    • •
  • 6 015 tis. Kč
    • •
  • GA ČR
Project

The role of dietary cholesterol in regulation of gene expression in the model of dietary induced hypercholesterolemia (NR9401)

The expression of genes that respond to dietary cholesterol and those responsible for development of hypercholesterolemia will be studied in experimental model) rat. Themechanism of increase in cholesterol concentration in VLDL, IDL...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2009
    • •
  • 4 928 tis. Kč
    • •
  • 4 857 tis. Kč
    • •
  • MZ
Project

The changes in the metabolism of cholesterol and its precursors in the patients in critical care. (NB7589)

, on the source of cholesterol (synthesis x absorption) and to outline a possible early requirements on cholesterol supply in critical disease, a human organism can be deprived of cholesterol. It is aggravated by its consum...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2003 - 2005
    • •
  • 2 134 tis. Kč
    • •
  • 2 134 tis. Kč
    • •
  • MZ
Project

Inhibition of intestinal absorption of sterols by hydrophobically modified polysaccharides (GAP503/11/2479)

pectin and palmitoyl chitosan), will by added to a cholesterol-containing diet of rats and their effect on cholesterol concentration in serum and liver, and a faecal output of cholesterol and bile acids will be examined. F...

GM - Potravinářství

  • 2011 - 2013
    • •
  • 6 035 tis. Kč
    • •
  • 6 035 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 240