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414 (0,073s) •

Project

The SMC5/6 complex in nucleome organization (LTC20033)

a) Characterization of activities of the SMC5/6 complexes b) Determination of the chromatin localization and dynamics of SMC5/6 c) Identification of chromatin loops dependent on SMC5/6 activities d) Development of visual...

Biochemistry and molecular biology

  • 2020 - 2023
    • •
  • 7 289 tis. Kč
    • •
  • 7 289 tis. Kč
    • •
  • MŠMT
Project

Molecular nature of DNA replication-coupled chromatin modulation (GA304/06/1691)

dependent modulation of early replicating chromatin domains manifested in situ by antibody-detected epiC positivity. By means of native chromatin immunoprecipitation and amino acid sequence analysis we want to identify chromati...

EA - Morfologické obory a cytologie

  • 2006 - 2008
    • •
  • 4 731 tis. Kč
    • •
  • 4 731 tis. Kč
    • •
  • GA ČR
Project

Organization of human nuclear chromatin (GA204/09/0973)

In this project, we want to deepen the knowledge of interphase chromatin organization. Human aneuploid carcinoma cell line and human diploid fibroblasts will serve in replicated human chromatin and its role in the organization of re...

EA - Morfologické obory a cytologie

  • 2009 - 2011
    • •
  • 4 237 tis. Kč
    • •
  • 4 237 tis. Kč
    • •
  • GA ČR
Project

Investigation of pathophysiology of human leukemias/lymphomas during manipulation of oncogenic microRNAs. (NS10310)

Translational research in hemato-oncology focused on identification of leukemia pathogenesis. Human chronic lymphocytic leukemia (CLL), difuse large B-cell lymphoma (DLBCL) and acute myeloid leukemia (AML) are newly characterized by disrupted negativ...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 6 232 tis. Kč
    • •
  • 6 232 tis. Kč
    • •
  • MZ
Project

Cooperative contribution of actin- and myosin-families to the chromatin dynamics and tranion in the cell nucleus (ME09101)

Identification of principles of collaborative action of actin-related (Arp6) and mypson (NM1) proteins in functional organization of the cell nucleus and chromatin. The project aims to asses especially their contribution to the organization ...

EB - Genetika a molekulární biologie

  • 2009 - 2010
    • •
  • 1 336 tis. Kč
    • •
  • 1 336 tis. Kč
    • •
  • MŠMT
Project

Cooperative contribution of actin- and myosin-families to the chromatin dynamics and tranion in the cell nucleus (LH12143)

Identification of principles of collaborative action of actin-related Arp6) and myosin (NM1) proteins in functional organization of the cell nucleus and chromatin, to the dynamics of chromatin movements, and to the formation of tran...

EB - Genetika a molekulární biologie

  • 2012 - 2014
    • •
  • 3 635 tis. Kč
    • •
  • 3 635 tis. Kč
    • •
  • MŠMT
Project

High throughput analysis of chromatin structure for development of novel diagnostic and therapeutic approaches in cancer. (2B06077)

DNA in nucleus is wrapped into nucleo-protein structure known as chromatin. Any transaction on DNA requires interactions of chromatin with transcription, replication-associated transcription and chromatin-modifying factors ...

EB - Genetika a molekulární biologie

  • 2006 - 2011
    • •
  • 53 217 tis. Kč
    • •
  • 47 631 tis. Kč
    • •
  • MŠMT
Project

Replication and chromatin organization in human cells (GA304/05/0374)

In this project, we want to show the high-resolution view of chromatin cells and human diploid fibroblasts. Recently, we showed that chromatin of HeLa replication results in the structural chromatin changes in the vicinity ...

EA - Morfologické obory a cytologie

  • 2005 - 2007
    • •
  • 4 362 tis. Kč
    • •
  • 4 362 tis. Kč
    • •
  • GA ČR
Project

Dynamic structure and function of the cell nucleus after irradiation (1P05OC084)

changes of structure of chromatin caused by low doses of ionizating radiation, changes of nucleus topology of chromatine...

BO - Biofyzika

  • 2005 - 2007
    • •
  • 2 522 tis. Kč
    • •
  • 1 043 tis. Kč
    • •
  • MŠMT
Project

Molecular analysis of the structure and function of typical and alternative telomeres in plants (GA204/02/0027)

, namely in the field of telomere-binding proteins, specific featuresof chromatin structure and telomere-end-conformation (presence of t-loops). Besides, the project......

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 4 982 tis. Kč
    • •
  • 2 843 tis. Kč
    • •
  • GA ČR
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