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619 (0,069s) •

Project

The study of pathogenesis of acute leukemias (AL) with 11q23 chromosomal rearrangement (GA301/01/0489)

The 11q23 chromosomal rearrangement, involving transcription factor MLL, has been implicated in an variety of acute leukemias (AL). The AL with MLL rearrangement are either de-novo or secondary (therapy related) and are ass...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 4 604 tis. Kč
    • •
  • 4 604 tis. Kč
    • •
  • GA ČR
Project

The cytogenetic analysis of chromosomal breakpoints in the mustard family (Brassicaceae) (GP521/09/P643)

. Chromosomal rearrangements involve breakage and rejoining of chromosomal DNA, very interesting are the contact site of rearranged blocks - chromosomal divided into 24conserved genomic blocks, which can b...

EA - Morfologické obory a cytologie

  • 2009 - 2011
    • •
  • 1 152 tis. Kč
    • •
  • 1 152 tis. Kč
    • •
  • GA ČR
Project

Chromosomal rearrangements with breakpoints in T cell receptor genes (GAP502/12/1966)

of chromosomes. Rearrangements of TR genes with oncogenes are recurrent in several T cell malignancies. It has been suggested that the number of trans-rearrangements with bothT cell receptor genes (TR) are rearranged

EB - Genetika a molekulární biologie

  • 2012 - 2014
    • •
  • 4 855 tis. Kč
    • •
  • 4 855 tis. Kč
    • •
  • GA ČR
Project

Genomic substrates of chromosome rearrangements and dysploidy during plant evolutionary diversification (GF21-07748L)

loss, chromosome rearrangements (CRs) and activity of transposable elements (TEs). Some CRs result in the reduction of duplicated chromosome sets (descending Biscutella genomes (Brassicaceae) with different genome sizes an...

Plant sciences, botany

  • 2021 - 2023
    • •
  • 12 160 tis. Kč
    • •
  • 11 821 tis. Kč
    • •
  • GA ČR
Project

Optimising molecular cytogenetic and molecular genetic diagnostics of chromosomal aberrations in patients with mental retardation (NR9457)

rearrangements, microdeletions, specification of supranumerary marker chromosomes. Detailed mapping of the extent of chromosomal aberrations and breakpoint location with the aim......

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 7 098 tis. Kč
    • •
  • 7 032 tis. Kč
    • •
  • MZ
Project

Analysis of chromosome pairing and recombination of homeologous chromosomes in (paleo)polyploid Brassicaceae species (MEB020828)

homeologous chromosomes as well as chromosome rearrangements in some haploid B. napus (n chromosome rearrangements in the B. napus genome. Comparative analysis of homeologous analysis of homeologous c...

EB - Genetika a molekulární biologie

  • 2008 - 2009
    • •
  • 72 tis. Kč
    • •
  • 72 tis. Kč
    • •
  • MŠMT
Project

Genome evolution in Cardamine allopolyploids of contrasting phylogenetic age (GAP501/10/1014)

rearrangements. The chromosome stability will be analyzed in the recent hybrid Cardamine. Nevertheless, surprisingly little is known about the chromosome stability in first, the combined GISH/CCP technique (Genomic In Situ...

EB - Genetika a molekulární biologie

  • 2010 - 2014
    • •
  • 6 743 tis. Kč
    • •
  • 6 743 tis. Kč
    • •
  • GA ČR
Project

Molecular cytogenetic analysis of complex chromosomal aberrations in bone marrow cells of patients with myelodysplastic syndrome (MDS) and/or acute myeloid leukemia (AML) and AND its contribution (NR9227)

Molecular cytogenetic analysis of complex chromosomal aberrations in patients with MDS and AML. Identification of chromosomes and/or chromosomal regions involved in complex karyotypes. Evaluation of the impact of complex

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 3 054 tis. Kč
    • •
  • 2 953 tis. Kč
    • •
  • MZ
Project

Molecular-cytogenetic analysis of marked plasma cells and prognostic significance of clonal chromosomal aberrations in multiple myeloma (NR8183)

Detection of selected clonal chromosomal aberrations in immunofluorescence-marked plasma cells in patients with multiple myeloma using molecular cytogenetic methods. Evaluation of the impact of selected chromosomal abnormalities on ...

FD - Onkologie a hematologie

  • 2004 - 2007
    • •
  • 3 329 tis. Kč
    • •
  • 3 091 tis. Kč
    • •
  • MZ
Project

Molecular cytogenetic analysis of structural chromosomal rearrangements in haematological malignancies (GA302/98/0071)

of acquired chromosomal translocation ( reciprocal, terminal, interstitial), in cells with special attention to the indentification of small rearrangements which are under limit of specific translocations, deletions and numerical <...

FP - Ostatní lékařské obory

  • 1998 - 2000
    • •
  • 1 381 tis. Kč
    • •
  • 1 381 tis. Kč
    • •
  • GA ČR
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