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796 (0,099s) •

Project

"Tailoring" therapy of chronic viral hepatitis B and C interferonem alfa (IZ4234)

Optimalization of interferon alpha therapy ("tailoring"therapy) in patients with chronic hepatitis B and C using monitoring viremia and detection of hepatitis C virus serotype.......

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1997 - 1999
    • •
  • 1 981 tis. Kč
    • •
  • 1 378 tis. Kč
    • •
  • MZ
Project

Comparison of efficacy of combination and induction treatment of chronic viral hepatitis C controlled multicentre randomised study (NI6015)

The author submits a controlled randomised study. Its objective is to verify the effectiveness of 2 new therapeutic schedules in the treatment of chronic viral hepatitis C. The study is supported by the Committee of the Czech Hepato...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2000 - 2002
    • •
  • 2 717 tis. Kč
    • •
  • 2 716 tis. Kč
    • •
  • MZ
Project

Significance of immunopathogenetic factors in the course of viral hepatitis for timely diagnostics of development of chronic hepatitis. (IZ1195)

FM - Hygiena

  • 1992 - 1994
    • •
  • 0 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • MZ
Project

Role of the host-dependent factors in prediction of antiviral treatment response in chronic hepatitis C (NT11235)

We shall validate the significance of the polymorphism -764G/C in the interferon gamma gene promoter and polymorphisms in IL28B gene in prediction of treatment response in chronic hepatitis C with peginterferon alpha and ribavirin i...

FE - Ostatní obory vnitřního lékařství

  • 2010 - 2015
    • •
  • 5 558 tis. Kč
    • •
  • 5 522 tis. Kč
    • •
  • MZ
Project

Role of heme oxygenase in the pathogenesis of hepatocelular injury in chronic HCV infection (NR9412)

associated with fibroproduction in the chronic HCV infection will be studied of the chronic HCV infection. Our expected results may help understanding the mechanismsof fibroproduction in chronic HVC infection and, therefor...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2007 - 2010
    • •
  • 4 641 tis. Kč
    • •
  • 4 467 tis. Kč
    • •
  • MZ
Project

Dependence of sustained virological response on the early viral kinetics in the treatment of chronic hepatitis C patients with combination of alpha-interferon, or pegylated interferon, and ribavirin. (NI7484)

We shall make a detection of serum HCV RNA levels in chronic hepatitis C patients treated by combination of alpha-interferon, or pegylated interferon, and ribavirin by polymerase chain reaction. We shall do this evaluation before tr...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2003 - 2005
    • •
  • 1 287 tis. Kč
    • •
  • 1 245 tis. Kč
    • •
  • MZ
Project

Disorder of Porphyprin Metabolism in Patients on regular Hemodialysis and its Association with chronic Hepatitis C virus Infection. (IZ3652)

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1996 - 1997
    • •
  • 530 tis. Kč
    • •
  • 514 tis. Kč
    • •
  • MZ
Project

Diagnosis of chronic hepatitis C virus infection by polymerase chain reaction. (IZ2263)

9F - 9

  • 1994 - 1996
    • •
  • 389 tis. Kč
    • •
  • 532 tis. Kč
    • •
  • MZ
Project

The use of histological activity index in evaluation of liver biopsies in chronic viral hepatitis (IZ4141)

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1997 - 1998
    • •
  • 645 tis. Kč
    • •
  • 645 tis. Kč
    • •
  • MZ
Project

Immunohistochemical detection of predictive factors of response to interferon therapy in patients with chronic hepatitis C (NR7814)

Hepatitis C virus (HCV) related alteration of signalling pathways and proteins (Jak-Stat, ERK1/2, NF-kB, MAP, etc.) regulated/activated by interferon (IFN) may lead to resistance to IFN treatment of patients with HCV infection. HCV infection...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 1 733 tis. Kč
    • •
  • 1 618 tis. Kč
    • •
  • MZ
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