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758 (0,083s) •

Project

Recovery from chonic lung hypoxia and effects of hypoxia in placenta. Pathophysiological basis for therapy. (GA305/08/0108)

Chronic hypoxia results in changes of vasculature of organs responsible for oxygen uptake ? the lung and placenta, which are reversible on return to normal oxygenation. The changes in pulmonary circulation complicate course of respi...

ED - Fyziologie

  • 2008 - 2012
    • •
  • 9 580 tis. Kč
    • •
  • 9 580 tis. Kč
    • •
  • GA ČR
Project

Vascular reactivity in pulmonary hypertension (GA13-01710S)

Chronic and intermittent lung hypoxia causes hypoxic pulmonary hypertension of chronic hypoxia, biochemical tissue changes induced by vascular hypoxia. Important diseases will be investigated in laboratory...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2013 - 2017
    • •
  • 8 709 tis. Kč
    • •
  • 8 709 tis. Kč
    • •
  • GA ČR
Project

Cardioprotective mechanisms of chronic intermittent and sustained hypoxia role of reoxygenation. (GA305/07/0875)

be substantially reduced by preceding adaptation to chronic intermittent hypoxia. This project reoxygenation, rather than hypoxia per se, is a crucial factor, which provides for the protective effects of chronic i...

ED - Fyziologie

  • 2007 - 2009
    • •
  • 3 089 tis. Kč
    • •
  • 3 089 tis. Kč
    • •
  • GA ČR
Project

The effect of neonatal hypoxia on the resistance of the adult myocardium to oxygen deficiency. (ND7607)

Myocardium exposed to chronic hypoxia in the early neonatal period can show different functional and mechanical properties in adulthood compared with myocardium not affected with hypoxia, particularly in a sense of ischemic...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2003 - 2005
    • •
  • 2 094 tis. Kč
    • •
  • 2 089 tis. Kč
    • •
  • MZ
Project

The role of mitochondria-associated hexokinase2 and the PI3K/Akt signalling pathway in the adaptation of rat heart to chronic hypoxia (GP14-04301P)

to chronic hypoxia, which has been shown to increase antioxidant defence capacity production by preferential ADP supply to OXPHOS. The inuence of chronic hypoxia regimens of chronic hypoxia and t...

ED - Fyziologie

  • 2014 - 2018
    • •
  • 2 974 tis. Kč
    • •
  • 2 974 tis. Kč
    • •
  • GA ČR
Project

The role of adrenergic signaling and oxidative stress in molecular mechanisms of cardioprotection induced by chronic hypoxia (IAAX01110901)

The major aim of this project is to advance our understanding of molecular mechanisms underlying cardioprotective effects of chronic hypoxia. We will analyze in detail the role of adrenergic and reactive oxygen species (ROS) signali...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2009 - 2013
    • •
  • 10 285 tis. Kč
    • •
  • 10 285 tis. Kč
    • •
  • AV ČR
Project

Dynamics and mechanisms of the chronic hypoxia-induced alterations in pulmonary and placental circulations (GA305/05/0672)

, such as chronic hypoxia, have never been compared and are poorly understood. Chronic hypoxic responsible for individual variability in PHT, specifically perinatal hypoxia, will also be studied. As the main cause ...

ED - Fyziologie

  • 2005 - 2007
    • •
  • 5 720 tis. Kč
    • •
  • 5 589 tis. Kč
    • •
  • GA ČR
Project

Cardioprotective mechanisms of adaptation to chronic hypoxia relation to preconditioning (GA306/98/0470)

The application is concerned with the endogenous protective machanisms underlying the enhanced ischaemic tolerance of the hearts adapted to chronic hypoxia the adaptation to chronic hypoxia increases cardiac resist...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 1998 - 2000
    • •
  • 2 412 tis. Kč
    • •
  • 1 834 tis. Kč
    • •
  • GA ČR
Project

Cardiac ischemic tolerance of spontaneously hypertensive rats expressing human C-reactive protein. (GA18-03207S)

adaptation to chronic hypoxia improves cardiac ischemic tolerance. However, in contrast to EETs, cardioprotection conferred by chronic hypoxia requires pro-oxidant and pro-inflammatory signalling. The aim of the p...

Physiology (including cytology)

  • 2018 - 2023
    • •
  • 7 138 tis. Kč
    • •
  • 6 697 tis. Kč
    • •
  • GA ČR
Project

Role of oxidative stress in ischemic tolerance of normoxic and chronically hypoxic myocardium (GP305/06/P372)

Adaptation to chronic hypoxia affords increased ischemic tolerance to acute and NO in the endogenous protective mechanism of chronic hypoxia may help to indetify molecular and chronic treatment with a ROS ...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2006 - 2008
    • •
  • 779 tis. Kč
    • •
  • 779 tis. Kč
    • •
  • GA ČR
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