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936 (0,092s) •

Project

Immunotherapy of chronic myeloid leukemia therapeutic vaccines in a mouse model and preparation of a clinical study (NC6957)

Creation of prerequisites for immunotherapy of chronic myeloid leukemia: development and testing of experimental vaccines against tumours expressing BCR_ABL fusion protein Immunological characterization of chronic ...

FD - Onkologie a hematologie

  • 2002 - 2004
    • •
  • 14 158 tis. Kč
    • •
  • 13 385 tis. Kč
    • •
  • MZ
Project

The role of cellular transport mechanisms in efficacy of imatinib mesylate treatment in patients with chronic myeloid leukemia (NS9627)

The aim of project is to clarify the further causes of resistance to imatinib in patients with chronic myeloid leukaemia that are associated with transport mechanisms influencing the intracellular levels of the drug.......

FD - Onkologie a hematologie

  • 2008 - 2010
    • •
  • 8 220 tis. Kč
    • •
  • 4 711 tis. Kč
    • •
  • MZ
Project

New molecular markers of residual disease in acute myeloid leukemia patients and of disease progression in myelodysplastic patients, and prediction of STI-571 responsiveness in chronic myeloid (NR8748)

New molecular markers of residual disease in acute myeloid leukemia patients and of disease progression in myelodysplastic patients, and prediction of STI-571 responsiveness in chronic myeloid leukemia pat...

FD - Onkologie a hematologie

  • 2006 - 2009
    • •
  • 6 316 tis. Kč
    • •
  • 5 783 tis. Kč
    • •
  • MZ
Project

Knowledge deepening on immunology of chronic myeloid leukemia necessary precondition of future terapeutic vaccine (NT12363)

Determination of the effects of chronic myeloid leukemia (CML) on immune profile of patient in dependence of its treatment modalities and the results of its treatment. Examination of leukemic cells, sampled prior to any the...

FD - Onkologie a hematologie

  • 2011 - 2015
    • •
  • 10 493 tis. Kč
    • •
  • 9 457 tis. Kč
    • •
  • MZ
Project

Molecular biology of chronic myeloid leukemia. (IZ1517)

9F - 9

  • 1993 - 1995
    • •
  • 339 tis. Kč
    • •
  • 678 tis. Kč
    • •
  • MZ
Project

Molecular diagnostics of chronic myeloid leukemia and acute promyeloid leukemia. (IZ3563)

FD - Onkologie a hematologie

  • 1996 - 1998
    • •
  • 1 719 tis. Kč
    • •
  • 1 569 tis. Kč
    • •
  • MZ
Project

Molecular prognostic factors in myeloid leukemia (NC7560)

Molecular prognostic factors in patients of acute and chronic myeloid leukemia. Expression of p21 Cip, Fas, FasL, DR 4 and 5, and Wt-1 genes detected at MRNA ( comparative and real-time RT-PCR) and protein level (flow cytom...

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 4 870 tis. Kč
    • •
  • 4 796 tis. Kč
    • •
  • MZ
Project

Early markers of resistance to imatinib in chronic myeloid leukemia treatment (NR8758)

The main objective of this project is the early identification of patients with chronic myeloid leukemia at high risk of resistance to imatinib (Glivec, STI571). We are going to introduce the method of ASO PCR with sensitiv...

FD - Onkologie a hematologie

  • 2006 - 2008
    • •
  • 7 760 tis. Kč
    • •
  • 7 188 tis. Kč
    • •
  • MZ
Project

Methylation of histone H3 as a prognostic marker of chronic myeloid leukemia remission (1QS500040508)

in granulocytes of patients with chronic myeloid leukemia (CML) without HP1 proteins. We chromatincondensation that may be linked to the leukemia cell proliferation capacity......

FD - Onkologie a hematologie

  • 2005 - 2009
    • •
  • 6 365 tis. Kč
    • •
  • 6 365 tis. Kč
    • •
  • AV ČR
Project

The role of in vitro sensitivity to tyrosine kinase inhibitors estimation in management of patients with chronic myeloid leukemia (NS9949)

Assessment of in vitro sensitivity of leukemic cells from patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors and its implications for the therapy management. Clones of in vitro imatinib-resistant...

FD - Onkologie a hematologie

  • 2008 - 2010
    • •
  • 3 717 tis. Kč
    • •
  • 3 713 tis. Kč
    • •
  • MZ
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