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5 681 (0,119s) •

Project

Adaptor protein PSTPIP2 and chronic multifocal osteomyelitis in mouse models and human patients (GA23-06676S)

Chronic recurrent multifocal osteomyelitis (CRMO) is a chronic disease characterized by autoinflammatory lesions in the bones. The molecular basis of the disease is unknown. The most important animal model of this disease i...

Biochemistry and molecular biology

  • 2023 - 2025
    • •
  • 9 235 tis. Kč
    • •
  • 9 043 tis. Kč
    • •
  • GA ČR
Project

Inprovement of diagnostics local and general therapy of chronic osteomyelitis (IZ3686)

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1996 - 1998
    • •
  • 1 277 tis. Kč
    • •
  • 1 195 tis. Kč
    • •
  • MZ
Project

Novel antimicrobial peptides for topical treatment of osteomyelitis and prevention of implant-related infections in orthopedics (NV16-27726A)

carriers into the focus of bacterial infection appears to be promising therapeutic method for the cure or prevention of osteomyelitis. For the experiments carried out on the model of induced osteomyelitis we will use local...

FI - Traumatologie a ortopedie

  • 2016 - 2019
    • •
  • 7 714 tis. Kč
    • •
  • 7 714 tis. Kč
    • •
  • MZ
Project

Molecular mechanisms of the regulation of inflammatory responses by adaptor protein PSTPIP2 (GA17-07155S)

chronic multifocal osteomyelitis, caused by the absence of adaptor protein PSTPIP2...

EC - Imunologie

  • 2017 - 2021
    • •
  • 6 978 tis. Kč
    • •
  • 5 991 tis. Kč
    • •
  • GA ČR
Project

Development and comprehensive evaluation of novel injectable, resorbable, porous bone substitute with controlled release of antimicrobial agents (NV18-05-00379)

Solution of bone defects is not always easy medical procedure, especially in the field of osteomyelitis, or near joint replacements on the surface of the attritor or exacerbate osteomyelitis. In the present project we will newly uti...

Orthopaedics

  • 2018 - 2022
    • •
  • 14 215 tis. Kč
    • •
  • 14 215 tis. Kč
    • •
  • MZ
Project

Use of antimicrobial peptides to treatment of musculoskeletal infections with the help of local carriers used in orthopedics (NT14218)

Despite improvements of therapeutic procedures, growing bacterial resistance to conventional antibiotics seriously complicates the treatment of orthopedic infectious not induce bacterial resistance, they are considered as a promisin...

FI - Traumatologie a ortopedie

  • 2013 - 2014
    • •
  • 1 371 tis. Kč
    • •
  • 1 371 tis. Kč
    • •
  • MZ
Project

Bioactive Glass-ceramics Used in Orthopaedic Surgery. (IZ3026)

FJ - Chirurgie včetně transplantologie

  • 1995 - 1997
    • •
  • 739 tis. Kč
    • •
  • 738 tis. Kč
    • •
  • MZ
Project

Inflammatory bowel disease From immunopathogenetic mechanisms to the development of potencial vaccine (IAA5020205)

colitis are severe chronic disorders whose etiology and pathogenesis remain unclear of immunoregulatory functions and impairment of the mucosal immune response to normal bacterial flora play a crucial role in the pathogenesis of

EC - Imunologie

  • 2002 - 2006
    • •
  • 6 168 tis. Kč
    • •
  • 4 688 tis. Kč
    • •
  • AV ČR
Project

Molecular characterization of adaptive antibiotic resistance and tolerance mechanisms of Staphylococcus aureus strains causing chronic infections (NV17-30460A)

Complex structural changes in the affected tissues develop during the course of chronic bacterial infection and along with antibiotic therapy act as strong stressors exerting a severe selective pressure and resulting in adapted ...

EE - Mikrobiologie, virologie

  • 2017 - 2020
    • •
  • 8 659 tis. Kč
    • •
  • 8 659 tis. Kč
    • •
  • MZ
Project

Role of Chlamydia pneumoniae in the pathogenesis of the chronic disease in humans (NI6811)

Evaluation of significance of various laboratory methods (serological methods, bacterial antigen and DNA detection( for the diagnosis of acute chronical infection with CH.pneumoniae. Detection of infection with CH. pneumoniae in pat...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2001 - 2003
    • •
  • 3 742 tis. Kč
    • •
  • 2 714 tis. Kč
    • •
  • MZ
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