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22 (0,084s) •

Project

Stop codon readthrough lessons from the tRNA anti-codon stem. (GF23-08669L)

to be employed in programmed stop codon readthrough in all organisms. Here, in the three and attempt to solve the structure of an 80S ribosome reading through a stop codon.......

Microbiology

  • 2023 - 2026
    • •
  • 17 973 tis. Kč
    • •
  • 17 973 tis. Kč
    • •
  • GA ČR
Project

Neglected players in human non-sense readthrough coming to light. (GA18-02014S)

its start and its stop, which is determined by one of three stop codons. Many codon readthrough. Since over 15% of human genetic diseases are caused by so called premature termination codons (PTC) that halt translation and...

Biochemistry and molecular biology

  • 2018 - 2022
    • •
  • 7 472 tis. Kč
    • •
  • 7 451 tis. Kč
    • •
  • GA ČR
Project

Deciphering molecular details of the stringent decoding of the AUG start codon during eukaryotic translation initiation. (GAP305/10/0335)

Start codon selection is a key step in translation as it sets the reading frame for decoding. The 40S ribosome has to scan the mRNA’s 5' UTR in its search for the AUG start codon and respond to a set of not well-understood signals t...

EB - Genetika a molekulární biologie

  • 2010 - 2014
    • •
  • 7 008 tis. Kč
    • •
  • 7 008 tis. Kč
    • •
  • GA ČR
Project

Trypanosomatids with in-frame sense stop codons dissecting molecular mechanisms behind the unique ambiguity of the genetic code (GA18-15962S)

trypanosomatid Blastocrithidia sp. in which all three stop codons are re-assigned as coding...

Biochemistry and molecular biology

  • 2018 - 2022
    • •
  • 7 589 tis. Kč
    • •
  • 6 861 tis. Kč
    • •
  • GA ČR
Project

Translation fidelity during biochemical and morphological differentiation in streptomyces (GA204/00/1252)

of UGA stop codon placed in a proximal part of B gene of bacterial luciferase and luxB, in which the UGA stop codon will be moved into the central part of the fusion while the codon context will be kept identical. We will....

EB - Genetika a molekulární biologie

  • 2000 - 2002
    • •
  • 1 277 tis. Kč
    • •
  • 1 072 tis. Kč
    • •
  • GA ČR
Project

Anaerobic ciliates as a model group to study alternative nuclear genetic codes (GA25-17400S)

these aberrations involve reassignments of stop codons. The most frequent is the reassignment of the UAG and UAA (=UAR) codons. It originated at least 14 times independently assay, we will trace how UAR codon reassignment ...

Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

  • 2025 - 2027
    • •
  • 11 532 tis. Kč
    • •
  • 11 532 tis. Kč
    • •
  • GA ČR
Project

Blastocrithidia and Trypanosoma as optimal models for testing the emergence and features of alternative genetic codes (GA22-14356S)

The genetic code is not absolutely universal, since several non-standard variants have been described in the mitochondrial, as well as the prokaryotic and eukaryotic genomes. The most common deviation represents a stop-to-sense codon all thr...

Biochemistry and molecular biology

  • 2022 - 2025
    • •
  • 9 794 tis. Kč
    • •
  • 9 505 tis. Kč
    • •
  • GA ČR
Project

PF 2025 (EH22_010/0012649)

The aim of the submitted project is to enable mobility of promising researchers who have submitted high quality project proposals to the calls of the HE MSCA PF programme and have been recommended for funding in these calls, but due to lack of funds ...

Microbiology

  • 2025 - 2029
    • •
  • 20 183 tis. Kč
    • •
  • 5 106 tis. Kč
    • •
  • MŠMT
Project

Structural and biochemical insights into miscoding by the eukaryotic ribosome. (GA20-00579S)

Recent studies revealed the involvement of glutamine tRNA in stop codon readthrough. Surprisingly, the efficiency of readthrough is not equal for all Glu-tRNA isoforms. The highest readthrough is manifested by the M isoform; i.e. the only i...

Microbiology

  • 2020 - 2022
    • •
  • 8 154 tis. Kč
    • •
  • 8 154 tis. Kč
    • •
  • GA ČR
Project

Development of vaccines against markers of cancer stem cells (NT11541)

and by the removal of their initiation codons in fusion genes. Detection of immune responses...

FD - Onkologie a hematologie

  • 2010 - 2013
    • •
  • 9 263 tis. Kč
    • •
  • 9 263 tis. Kč
    • •
  • MZ
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