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3 288 (0,213s) •

Project

Optical imaging of single protein dynamics (LL1602)

and tracking the conformational dynamics of proteins at a single-molecular level the conformations of a protein in its native environment is a crucial step in revealing its of the protein conformation...

CF - Fyzikální chemie a teoretická chemie

  • 2016 - 2021
    • •
  • 40 738 tis. Kč
    • •
  • 40 738 tis. Kč
    • •
  • MŠMT
Project

Characterization of intrinsically disordered proteins (GF20-05789L)

Intrinsically disordered proteins (IDPs) are biopolymers interesting both from, but are best characterized by ensembles of conformations. Computer simulations and nuclear developed methods to sample multiple conformational ...

Biophysics

  • 2020 - 2022
    • •
  • 8 686 tis. Kč
    • •
  • 8 686 tis. Kč
    • •
  • GA ČR
Project

Multiscale methods for simulations of unstructured proteins (LUC24136)

-grained models of protein dynamics. These models will be used to build a map of the conformational space of the protein. Finally, by molecular dynamics simulations and metadynamice, the conformational space will b...

Biochemistry and molecular biology

  • 2024 - 2026
    • •
  • 2 660 tis. Kč
    • •
  • 2 660 tis. Kč
    • •
  • MŠMT
Project

Complex structural analysis of interaction at the protein - nucleic acid interface by unique bioinformatic descriptors (MEB021032)

: While Dr. De Brevern developed tools for classification of local protein conformation, Dr. Schneider developed protocol for classification of NA. The protein-NA by their local conformations. Reduction of conf...

BO - Biofyzika

  • 2010 - 2011
    • •
  • 106 tis. Kč
    • •
  • 106 tis. Kč
    • •
  • MŠMT
Project

Wild type and mutant p53 tumor suppressor protein. Intermolecular interactions, changes in conformation and new micro-methods of their analysis (IAA500040513)

will be applied to study changes in conformation and interactions of mutated p53 proteinThe tumor suppressor protein p53 plays a critical role in the control of cell suppressor function of the p53 protein and gain...

CE - Biochemie

  • 2005 - 2008
    • •
  • 2 930 tis. Kč
    • •
  • 2 930 tis. Kč
    • •
  • AV ČR
Project

Exploring Conformational Space of Short Peptides by Advanced Quantum Chemical and Solvation Methods A Key to Understand Protein Structures? (GA17-24155S)

conformational space of short peptides and investigation of the relation between the variability of this space and protein folding. This involves development and calibration, such as COSMO-RS. A full conformational space o...

CF - Fyzikální chemie a teoretická chemie

  • 2017 - 2019
    • •
  • 5 100 tis. Kč
    • •
  • 3 531 tis. Kč
    • •
  • GA ČR
Project

Influence of tyrosine oxidation on structure of neurodegenerative proteins (GA17-00121S)

of the protein conformation. Selected targets for such conformational changesStructural changes of neurodegenerative proteins caused by oxidative stress of tyrosine in proteins such as 3-chloro-L-tyrosin...

BO - Biofyzika

  • 2017 - 2021
    • •
  • 5 864 tis. Kč
    • •
  • 5 669 tis. Kč
    • •
  • GA ČR
Project

From conformation to biological functions of HP1 protein (GA18-07384S)

-translation modifications and conformation properties of heterochromatin protein 1 (HP1 by means of FLIM-FRET microscopy as well as biological functions of HP1 proteins with different FLIM characteristics. Three variants o...

Cell biology

  • 2018 - 2020
    • •
  • 10 461 tis. Kč
    • •
  • 8 850 tis. Kč
    • •
  • GA ČR
Project

Study the conformational changes of polycationic sequential polypeptide complexes with porphyrins using vibrational circular dichroism spectroscopy (GP203/06/P371)

Interactions of porphyrins with proteins, during which the porphyrin-protein accepted and mechanism of polypeptide and protein interactions with porphyrins has been is focused into a new way. The main goal is to study the <...

CB - Analytická chemie, separace

  • 2006 - 2008
    • •
  • 672 tis. Kč
    • •
  • 672 tis. Kč
    • •
  • GA ČR
Project

Protein-DNA Complexes and Force Field Development (GA20-28231S)

development in NA FFs. Conformational adaptations of DNA binding to protein involve wellThe aim of this proposal is to explore protein-DNA interactions hand in hand and we have indications that these problems may propagate...

Physical chemistry

  • 2020 - 2022
    • •
  • 2 687 tis. Kč
    • •
  • 2 687 tis. Kč
    • •
  • GA ČR
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