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Projects

6 655 projects (0,139s) •

Project

Development of a method for conformational mapping of the human genome regions of medical interest (GA302/98/P112)

Development of a method for conformational mapping of the human genome regions of medical interest. Project terminated, because the applicant changed the employer.......

EB - Genetika a molekulární biologie

  • 1998 - 1998
    • •
  • 431 tis. Kč
    • •
  • 238 tis. Kč
    • •
  • GA ČR
Project

VŠCHT - Setnička Study of conformational changes of optically active molecules induced by noncovalent interactions using vibrational circular dichroism spectroscopy (LZ1K03012)

utilized in combination with other spectral methods to study conformational changesStructural studies of optically active molecules and their conformational changes induced by noncovalent interactions are becoming...

CB - Analytická chemie, separace

  • 2003 - 2005
    • •
  • 837 tis. Kč
    • •
  • 401 tis. Kč
    • •
  • MŠMT
Project

Optical imaging of single protein dynamics (LL1602)

of the protein conformation. An experimental approach will be developed enabling real-time tracking of conformational changes of single-proteins at timescales ranging from sub and tracking the conformational dynam...

CF - Fyzikální chemie a teoretická chemie

  • 2016 - 2021
    • •
  • 40 738 tis. Kč
    • •
  • 40 738 tis. Kč
    • •
  • MŠMT
Project

Wild type and mutant p53 tumor suppressor protein. Intermolecular interactions, changes in conformation and new micro-methods of their analysis (IAA500040513)

in conformational changes of the DBD, which strongly influence the biochemical activities will be applied to study changes in conformation and interactions of mutated p53 protein......

CE - Biochemie

  • 2005 - 2008
    • •
  • 2 930 tis. Kč
    • •
  • 2 930 tis. Kč
    • •
  • AV ČR
Project

Study the conformational changes of polycationic sequential polypeptide complexes with porphyrins using vibrational circular dichroism spectroscopy (GP203/06/P371)

is focused into a new way. The main goal is to study the conformational changes interaction withporphyrins. A modern and highly conformation sensitive technique......

CB - Analytická chemie, separace

  • 2006 - 2008
    • •
  • 672 tis. Kč
    • •
  • 672 tis. Kč
    • •
  • GA ČR
Project

Conformational Transitions in Plasmid DNA (IAA1004301)

DNA undergoes conformational transitions which substantially change its into DNA conformational transitions is CD spectroscopy, Which nevertheless complementary methods based on the fact that UV-induced DNA damage is DNA

BO - Biofyzika

  • 2003 - 2005
    • •
  • 1 284 tis. Kč
    • •
  • 751 tis. Kč
    • •
  • AV ČR
Project

Biochemistry, structural and cellular biology of ""non-classical"" antitumor platinum compounds (OC D20.001)

The major objective of this project is a fundamental research of conformational alterations induced in DNA by novel ""non-classical"" platinum compounds and processing of these changes in tumor cells. The results will improve theore...

CE - Biochemie

  • 2001 - 2005
    • •
  • 4 275 tis. Kč
    • •
  • 2 040 tis. Kč
    • •
  • MŠMT
Project

Influence of tyrosine oxidation on structure of neurodegenerative proteins (GA17-00121S)

, the modifications could influence the onset of the neurodegenerative diseases caused by changes of the protein conformation. Selected targets for such conformational changesStructural changes of neurodeg...

BO - Biofyzika

  • 2017 - 2021
    • •
  • 5 864 tis. Kč
    • •
  • 5 669 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanism of antitumor activity of bisplatinum complexes (GA307/97/P029)

conformational changes in DNA molecule caused by interstrand cross-links of binuclear platinum complexes. Conformational changes will be studied with aid of analysis containing interstrand cross-links. The extent ...

CE - Biochemie

  • 1997 - 1999
    • •
  • 647 tis. Kč
    • •
  • 476 tis. Kč
    • •
  • GA ČR
Project

From conformation to biological functions of HP1 protein (GA18-07384S)

During cell differentiation and DNA repair processes, changes in post-translation modifications and conformation properties of heterochromatin protein 1 (HP1) are expected. These changes, determined by epigenetic events, wi...

Cell biology

  • 2018 - 2020
    • •
  • 10 461 tis. Kč
    • •
  • 8 850 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 6 655