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75 (0,074s) •

Project

Difference in the behaviour of the freshly isolated and cryo-preserved ovarian cancer cells and its clinical significance (NR8768)

Determination of difference in the behaviour (morphology, motility, proliferation activity) of the freshly isolated and cryo-preserved ovarian cancer cells and its clinical significance. The establishment of Tissue and Serum Biobank of the f...

FK - Gynekologie a porodnictví

  • 2006 - 2008
    • •
  • 3 493 tis. Kč
    • •
  • 3 379 tis. Kč
    • •
  • MZ
Project

Crosstalk between transcription and translation (LL2008)

by ribosomes, thus coupling transcription to translation. Indeed, recent cryo-electron microscopy (cryo-EM) studies report that RNA polymerase and ribosome may interact the structures of complexes using cryo-EM. The state-...

Genetics and heredity (medical genetics to be 3)

  • 2020 - 2025
    • •
  • 48 953 tis. Kč
    • •
  • 48 953 tis. Kč
    • •
  • MŠMT
Project

Structural basis for bacterial ribosome rescue and recycling (8J18DE010)

1. Cryo-EM structure of ArfA bound to a non-stop ribosome The goal of this project is to ascertain how ArfA initially binds to the non-stop ribosomes before translating ribosomes. 2. Cryo-EM structure of an ArfA-RF2-RF3 recycling co...

Cell biology

  • 2018 - 2019
    • •
  • 66 tis. Kč
    • •
  • 66 tis. Kč
    • •
  • MŠMT
Project

Structural basis for co-transcriptional nucleosome reassembly mediated by Spt6 (GA22-19896S)

by a combination of single particle cryo-electron microscopy (cryo-EM) and biochemical in a defined biochemical system and we will determine a cryo-EM structure of transcribing......

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 9 832 tis. Kč
    • •
  • 9 832 tis. Kč
    • •
  • GA ČR
Project

Simultaneous gene transcription and translation (GJ20-16013Y)

in bacteria and visualize the structures of coupled complexes by cryo-electron microscopy requires coupled transcription-translation. We will use cryo-electron tomography......

Biochemical research methods

  • 2020 - 2022
    • •
  • 9 834 tis. Kč
    • •
  • 9 834 tis. Kč
    • •
  • GA ČR
Project

Using cryo-electron tomography for understanding function of the ciliary tip domain (GC20-23165J)

labeling combined with cryo-electron tomography to obtain a 3D high-resolution model...

Cell biology

  • 2020 - 2022
    • •
  • 7 398 tis. Kč
    • •
  • 7 398 tis. Kč
    • •
  • GA ČR
Project

Quantitative imaging of beam sensitive samples using correlative signal detection in a cryo-SEM (GA17-15451S)

preparation using cryo-techniques, where we can expect the preservation of the sample...

JB - Senzory, čidla, měření a regulace

  • 2017 - 2019
    • •
  • 6 426 tis. Kč
    • •
  • 6 081 tis. Kč
    • •
  • GA ČR
Project

Advanced cryo-optofluidic platform for correlative light and electron microscopy (CLEM) (GA23-07962S)

cryo-scanning EM and transmission EM. This new, completely unique assembly...

Atomic, molecular and chemical physics (physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect)

  • 2023 - 2025
    • •
  • 7 608 tis. Kč
    • •
  • 6 261 tis. Kč
    • •
  • GA ČR
Project

Structural protein disorder brings order into bacterial transcription (GA22-12023S)

and the primary sigma factor (SigA) using cryo-electron microscopy (cryo-EM), (2) structurally resonance and/or cryo-EM. This study will thus bring urgently needed information about......

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 12 266 tis. Kč
    • •
  • 12 266 tis. Kč
    • •
  • GA ČR
Project

In situ visualization of ATPase Inhibitory Factor 1 (IF1) in mitochondrial ultrastructure by high-resolution cryo-electron tomography (GA24-10325S)

will use cutting-edge cryo-electron and superresolution microscopy to describe its...

Biochemistry and molecular biology

  • 2024 - 2026
    • •
  • 10 049 tis. Kč
    • •
  • 10 049 tis. Kč
    • •
  • GA ČR
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