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138 (0,097s) •

Project

Structural basis for bacterial ribosome rescue and recycling (8J18DE010)

1. Cryo-EM structure of ArfA bound to a non-stop ribosome The goal of this project is to ascertain how ArfA initially binds to the non-stop ribosomes before translating ribosomes. 2. Cryo-EM structure of an ArfA-RF...

Cell biology

  • 2018 - 2019
    • •
  • 66 tis. Kč
    • •
  • 66 tis. Kč
    • •
  • MŠMT
Project

Crosstalk between transcription and translation (LL2008)

by ribosomes, thus coupling transcription to translation. Indeed, recent cryo-electron microscopy (cryo-EM) studies report that RNA polymerase and ribosome may interact the structures of complexes using cryo-E...

Genetics and heredity (medical genetics to be 3)

  • 2020 - 2025
    • •
  • 48 953 tis. Kč
    • •
  • 48 953 tis. Kč
    • •
  • MŠMT
Project

Structural basis for co-transcriptional nucleosome reassembly mediated by Spt6 (GA22-19896S)

by a combination of single particle cryo-electron microscopy (cryo-EM) and biochemical in a defined biochemical system and we will determine a cryo-EM structure of transcribing......

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 9 832 tis. Kč
    • •
  • 9 832 tis. Kč
    • •
  • GA ČR
Project

Advanced cryo-optofluidic platform for correlative light and electron microscopy (CLEM) (GA23-07962S)

cryo-scanning EM and transmission EM. This new, completely unique assembly (RS) and electron microscopy (EM). The chip will allow effective cryogenic......

Atomic, molecular and chemical physics (physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect)

  • 2023 - 2025
    • •
  • 7 608 tis. Kč
    • •
  • 6 261 tis. Kč
    • •
  • GA ČR
Project

Structural characterization of NuA4 with a nonhistone acetylation target (8J25FR006)

) preparation of a sample of bound NuA4 with acetylation target for Cryo-EM, 5) determination of the three-dimensional structure by Cryo-EM and definition of key cues determination using Cryo-EM.....

Biochemistry and molecular biology

  • 2025 - 2026
    • •
  • 157 tis. Kč
    • •
  • 157 tis. Kč
    • •
  • MŠMT
Project

Molecular basis of regulation of cyclin-dependent kinase CDK16 by 14-3-3 proteins (GA25-15222S)

propose performing cryo-EM reconstruction of the CDK16:pCCNY:14-3-3, pCCNY:14-3-3 measurements, and H/D exchange coupled to MS. Our preliminary cryo-EM maps of the CDK16......

Biochemistry and molecular biology

  • 2025 - 2027
    • •
  • 12 110 tis. Kč
    • •
  • 12 001 tis. Kč
    • •
  • GA ČR
Project

Structural protein disorder brings order into bacterial transcription (GA22-12023S)

and the primary sigma factor (SigA) using cryo-electron microscopy (cryo-EM), (2) structurally resonance and/or cryo-EM. This study will thus bring urgently needed information about......

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 12 266 tis. Kč
    • •
  • 12 266 tis. Kč
    • •
  • GA ČR
Project

Structural characterisation of RAD51-G4 complex and its biological role (GA25-17326S)

complex and map the interaction sites using NMR, cryo-EM and AFM. We will also...

Biochemistry and molecular biology

  • 2025 - 2027
    • •
  • 8 703 tis. Kč
    • •
  • 8 703 tis. Kč
    • •
  • GA ČR
Project

Simultaneous gene transcription and translation (GJ20-16013Y)

in bacteria and visualize the structures of coupled complexes by cryo-electron microscopy requires coupled transcription-translation. We will use cryo-electron tomography......

Biochemical research methods

  • 2020 - 2022
    • •
  • 9 834 tis. Kč
    • •
  • 9 834 tis. Kč
    • •
  • GA ČR
Project

Molecular architecture of ADAR - RNA complexes (GA18-11397S)

to GluR-2 R/G and NEIL1 pre-mRNAs, respectively, using cryo-electron microscopy...

Biochemistry and molecular biology

  • 2018 - 2022
    • •
  • 8 209 tis. Kč
    • •
  • 8 023 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 138