All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”
EN
ČeštinaEnglish

Filters

39 (0,118s) •

Project

Access to unique modulators of adenylyl cyclase (GJ15-10504Y)

Adenylyl cyclases, the cAMP-producing enzymes, are involved in many important by adenylyl cyclases are isoform-dependent and may be linked to important human illnesses for therapeutic purposes. Significant challenge in validation of...

CC - Organická chemie

  • 2015 - 2017
    • •
  • 4 751 tis. Kč
    • •
  • 4 751 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms of membrane interaction and translocation of adenylate cyclase toxin from Bordetella pertussis (GA15-09157S)

The multifunctional adenylate cyclase toxin (CyaA) is a key virulence factor of Bordetella pertussis that causes a highly contagious respiratory disease called pertussis or whooping cough. CyaA is a fusion of an N-terminal adenylate cycl...

CE - Biochemie

  • 2015 - 2017
    • •
  • 5 994 tis. Kč
    • •
  • 5 994 tis. Kč
    • •
  • GA ČR
Project

Role of the pore-forming activity in adenylate cyclase toxin action and Bordetella virulence (GAP302/12/0460)

The adenylate cyclase toxin-hemolysin (CyaA) is a multifunctional RTX protein playing a key role in virulence of pathogenic Bordetella. It translocates an adenylate cyclase enzyme into cytosol of host phagocytes and subverts their b...

CE - Biochemie

  • 2012 - 2016
    • •
  • 15 307 tis. Kč
    • •
  • 15 307 tis. Kč
    • •
  • GA ČR
Project

Investigation of the mechanism of membrane translocation of the adenylate cyclase toxin (IAA5020907)

The adenylate cyclase toxin (ACT) paralyses a variety of cells by uncontrolled synthesis of cAMP. Penetration of ACT into cells is a rather iniwue example of spontaneous protein translocation directly across the cellular membrane. Elucidatio...

CE - Biochemie

  • 1999 - 2003
    • •
  • 7 321 tis. Kč
    • •
  • 4 975 tis. Kč
    • •
  • AV ČR
Project

Nature and role(s) of the posttranslational modification(s) required for activities of an RTX toxin the adenylate cyclase toxin of bordetella pertussis (GA310/95/1048)

EE - Mikrobiologie, virologie

  • 1995 - 1997
    • •
  • 1 030 tis. Kč
    • •
  • 1 030 tis. Kč
    • •
  • GA ČR
Project

Deciphering the role of acylated domain in the membrane penetration of Bordetella pertussis adenylate cyclase toxin (GA19-04607S)

The adenylate cyclase toxin-hemolysin (CyaA) plays a key role in virulence of the whooping cough agent Bordetella pertussis. CyaA translocates an AC enzyme into cytosol of CD11b+ phagocytes and subverts their bactericidal functions by unregu...

Microbiology

  • 2019 - 2021
    • •
  • 9 821 tis. Kč
    • •
  • 9 821 tis. Kč
    • •
  • GA ČR
Project

Mechanisms of membrane interaction and cytotoxic activity of adenylate cyclase (IAA5020406)

Penetration of adenylate cyclase toxin (ACT) into target cells is a unique example of direct translocation of a toxic enzyme across the target cytoplasmic membrane. Its understanding is, hence, of general relevance for deciphering the princi...

CE - Biochemie

  • 2004 - 2008
    • •
  • 6 250 tis. Kč
    • •
  • 5 910 tis. Kč
    • •
  • AV ČR
Project

Targeted drug design for bioterrorism prevention. Development of effective inhibitors of the adenylate cyclase toxin of Bordetella pertusis and Bacillus anthracis. (VG20102015046)

inhibitorsof the adenylate cyclase toxin of Bordetella pertusis and Bacillus anthracis...

CC - Organická chemie

  • 2010 - 2015
    • •
  • 41 350 tis. Kč
    • •
  • 41 345 tis. Kč
    • •
  • MV
Project

Molecular mechanism of adenylate cyclase toxin penetration into phagocytes (IAA500200914)

We propose to investigate the mechanistic details of adenylate cyclase toxin (CyaA) penetration across cellular membrane of myeloid phagocytes. Structural requirements for CyaA interaction with the beta-2 integrin receptor CD11b/CD18 and for...

EB - Genetika a molekulární biologie

  • 2009 - 2013
    • •
  • 7 666 tis. Kč
    • •
  • 7 666 tis. Kč
    • •
  • AV ČR
Project

Interaction of adenylate cyclase toxin with complement receptor 3 (GAP302/11/0580)

The adenylate cyclase toxin (CyaA) is a key virulence factor of the whooping cough agent Bordetella pertussis that binds host myeloid phagocytic cells through the beta-2 integrin CD11b/CD18 (complement receptor 3). The mechanism of CyaA-rece...

EB - Genetika a molekulární biologie

  • 2011 - 2015
    • •
  • 12 958 tis. Kč
    • •
  • 12 958 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 39