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19 (0,071s) •

Project

The role of cyclooxygenase-2 in renal function control (NK6664)

A specific inhibitor of cyclooxygenase-2, COX-2, which function within the kidney is not yet known, will be infused intrarenally in rats and blood pressure and renal function will be measured.......

FP - Ostatní lékařské obory

  • 2001 - 2003
    • •
  • 1 772 tis. Kč
    • •
  • 1 657 tis. Kč
    • •
  • MZ
Project

Cyclooxygenase-2 polymorphisms and the development of nephropathy in diabetes (NR9368)

Using molecular biological techniques we will study -765GC polymorphisms in COX-2 gene and their possible impact on monocytic COX-2 phenotype in diabetic patients with nephropathy in comparison with patients without DN and healthy subjects.......

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 3 446 tis. Kč
    • •
  • 3 386 tis. Kč
    • •
  • MZ
Project

Activation of adenosine receptors combined with cyclooxygenase inhibition in modulation of radiation-induced myelosuppression (GA305/08/0158)

Hitherto performed studies of the applicants of this project have demonstrated the effectiveness of two original experimental pharmacological approaches aimed at stimulation of  regeneration of hematopoiesis supressed by exposure of  a mammalian orga...

FD - Onkologie a hematologie

  • 2008 - 2012
    • •
  • 5 001 tis. Kč
    • •
  • 5 001 tis. Kč
    • •
  • GA ČR
Project

The role of neurotransmitters in mechanism of action of non-opioid analgesics (NR9072)

The primary objective is effort for definition of alternative mechanisms of antinociceptive/analgesic actions for non-opioid analgesic drugs (paracetamol and pyrazolones)beyond the inhibition of cyclooxygenases. The major purpose of the proj...

FR - Farmakologie a lékárnická chemie

  • 2006 - 2008
    • •
  • 1 276 tis. Kč
    • •
  • 1 265 tis. Kč
    • •
  • MZ
Project

Identification of Cyclooxygenase and Lipoxygenase Inhibitors from Vine Grapes (7AMB13AT008)

The aim is to elucidate, if - besides resveratrol - there are some other compounds contained in wine which are able to inhibit the activity of COX-1, COX-2 and 5-LOX enzymes. The inhibitory activity of studied compounds will be assessed in vitro on t...

EC - Imunologie

  • 2013 - 2014
    • •
  • 150 tis. Kč
    • •
  • 150 tis. Kč
    • •
  • MŠMT
Project

Selective COX-1 inhibition as cardioprotective therapeutical target (LTC18065)

Project is aimed to synthesis, optimization and evaluation of natural products and their derivatives with potential cardioprotective effects. We will focus on therapeutic options of selective cyclooxygenase-1 inhibitors, optionally with seco...

Organic chemistry

  • 2018 - 2021
    • •
  • 4 086 tis. Kč
    • •
  • 4 086 tis. Kč
    • •
  • MŠMT
Project

Exploration of grapevine diversity in production of health promoting compounds (LD11005)

. period) 2. Inhibition of cyclooxygenases (anti-inflammatory activity 2. period) 3...

GM - Potravinářství

  • 2011 - 2014
    • •
  • 1 640 tis. Kč
    • •
  • 1 640 tis. Kč
    • •
  • MŠMT
Project

Redox reactions of cyclooxygenase-2 inhibitors and their reactive intermediates in supramolecular nanocavities (KJB400400603)

The main idea of the project is to study the reduction mechanism of pharmacologically important drugs - cyclo-oxygenase-2 inhibitors in the presence of cyclodextrins. Cyclodextrins with different hydrophobicity of their interior nanocavity and thus w...

CG - Elektrochemie

  • 2006 - 2008
    • •
  • 1 545 tis. Kč
    • •
  • 1 545 tis. Kč
    • •
  • AV ČR
Project

Changes of expression of pro-inflammatory enzymes caused by isoquinoline alkaloids during differentiation of promyelocytes into neutrophils (GP303/06/P193)

, myeloperoxidase (MPO), and cyclooxygenase 2 (COX-2), human promyelocytic leukemia HL-60 cells...

CE - Biochemie

  • 2006 - 2008
    • •
  • 1 044 tis. Kč
    • •
  • 1 044 tis. Kč
    • •
  • GA ČR
Project

The role of c-Myb and Cox-2 proteins in colon carcinogenesis (GA301/09/1115)

Colon carcinomas are frequent malignant tumors in the Czech Republic. c-Myb is significantly involved in control of differentiation, proliferartion and apoptosis of colon cells. This transcription factor can regulate phenotype of a cell by control of...

FD - Onkologie a hematologie

  • 2009 - 2012
    • •
  • 3 915 tis. Kč
    • •
  • 3 915 tis. Kč
    • •
  • GA ČR
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