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107 (0,181s)

Project

Improvement of care for patients with cystic fibrosis by early and efficient diagnosis via two-tier neonatal screening programme (1A8236)

The aim is to assess the efectivity of newborn screening for cystic fibrosis in the condition of Czech Republic....

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
  • 6 193 tis. Kč
  • 6 182 tis. Kč
  • MZ
Project

Immune system in children with cystic fibrosis III. - factors modifying the course of the disease (NI7486)

Project...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2003 - 2005
  • 1 808 tis. Kč
  • 1 786 tis. Kč
  • MZ
Project

Risk factors leading to diabetes mellitus in patients with cystic fibrosis in the Czech republic (NB6461)

Impaired glucose tolerance and diabetes mellitus in patients with cystic fibrosis. Relation of clinical parameters, CFTR genotype and markers of insulitis (HLA class II., antibodies IAA, IA-2 GAD). Determination of the risk factors,...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2001 - 2003
  • 3 105 tis. Kč
  • 3 043 tis. Kč
  • MZ
Project

Pseudomonas aeruginosa in patients with cystic fibrosis an impact of early PCR-indicated therapy, identification of routes of the infection spread (NR7974)

The effective treatment of infection with Pseudomonas aeruginosa in patients with cystic fibrosis requires early pathogen detection. Highly sensitive detection of the P.aeruginosa using nested PCR will be the indication to start an ...

FG - Pediatrie

  • 2004 - 2006
  • 3 282 tis. Kč
  • 2 931 tis. Kč
  • MZ
Project

Optimalization of newborn screening of cystic fibrosis (NS9986)

Newborn screening for cystic fibrosis (NSCF) is based on examination of concentration of imunoreactive trypsinogen (IRT) and DNA analysis of CFTR gene in blood spots on screening cards. DNA analysis could be replaced with pancreatit...

FG - Pediatrie

  • 2008 - 2011
  • 10 604 tis. Kč
  • 10 597 tis. Kč
  • MZ
Project

The application of 13C breath test in padiatics. (NE6164)

To work out the common methydology for 13c breath tests in pediatrics.To use the 13c breath tests for studying of gastric emptying rate in the newborns and for assesment of the exocrine pancreatic function in cystic fibrosis patient...

FG - Pediatrie

  • 2000 - 2002
  • 1 612 tis. Kč
  • 1 129 tis. Kč
  • MZ
Project

The significance of inflammatory and oxidative stress biomarkers in exhaled breath condensate for progression of cystic fibrosis (NR8304)

Inflammation and oxidative stress take part in progression of cystic fibrosis bronchopulmonary disease. Biomarkers of inflammation (leukotrien B4, interleukin 6, interleukin 8 and neutrophil elastase) and oxidative stress (nitrites,...

FC - Pneumologie

  • 2005 - 2007
  • 2 459 tis. Kč
  • 2 377 tis. Kč
  • MZ
Project

Optimization of cystic fibrosis patient-derived cellular models to asses restoration of CFTR function in patients with cystic fibrosis (NU23-07-00079)

The discovery of modulators that target cystic fibrosis transmembrane conductance regulator (CFTR) protein has opened the era of cystic fibrosis (CF) curative treatment. Although this therapy is termed mutation spe...

Paediatrics

  • 2023 - 2026
  • 15 195 tis. Kč
  • 15 195 tis. Kč
  • MZ
Project

Cystic Fibrosis (CF) - Ineraction between CF background and infection. (NR8458)

This project focus on the interaction between immune system of cystic fibrosis patients and infection caused by bacterial strains of Pseudomonas aeruginosa and bacterial complex of Burkholderia cepacia. In first part we study dendri...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2005 - 2009
  • 2 912 tis. Kč
  • 2 903 tis. Kč
  • MZ
Project

Virulence factors of Burkholderia cepacia complex bacteria involved at various stages of infection in patients with cystic fibrosis (LD11029)

The aim of the project is to describe changes in gene expression of the pathogen (Burkholderia cepacia complex, Bcc) during the course of the infection in patients with cystic fibrosis. By using DNA chip technology we wil examine an...

EE - Mikrobiologie, virologie

  • 2011 - 2014
  • 3 038 tis. Kč
  • 2 444 tis. Kč
  • MŠMT
  • 1 - 10 out of 107