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11 (0,062s) •

Project

New trends in the treatment of cystic fibrosis. (IZ2056)

FG - Pediatrie

  • 1994 - 1998
    • •
  • 4 384 tis. Kč
    • •
  • 5 168 tis. Kč
    • •
  • MZ
Project

Optimalization of a model of nutritional care of adult patients with cystic fibrosis. (IZ3529)

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1996 - 1998
    • •
  • 800 tis. Kč
    • •
  • 800 tis. Kč
    • •
  • MZ
Project

The Biological and Prognostic Significance of c-erbB-2 Oncogene Expression in Benign and Malignant Breast Lesions. (IZ2924)

FD - Onkologie a hematologie

  • 1995 - 1997
    • •
  • 400 tis. Kč
    • •
  • 400 tis. Kč
    • •
  • MZ
Project

Non-tuberculous mycobacteria in the Czech Republic current risks and improved prevention (NU20-09-00114)

The epidemiological situation of tuberculosis is favourable in the Czech Republic thanks to a functional control and diagnosis system. However, we are facing serious shortcomings in today's clinical practice at all levels of the emerging issue of myc...

Epidemiology

  • 2020 - 2023
    • •
  • 11 432 tis. Kč
    • •
  • 11 432 tis. Kč
    • •
  • MZ
Project

Intestinal organoids as an in-vitro model for predicting the response to therapies correcting molecular defects in cystic fibrosis (NU20-07-00049)

The discovery of modulators that target cystic fibrosis transmembrane conductance regulator (CFTR) protein has opened the era of CF curative treatment. Although this therapy is termed mutation specific, strikingly a level of therapeutic response diff...

Paediatrics

  • 2020 - 2023
    • •
  • 11 461 tis. Kč
    • •
  • 11 461 tis. Kč
    • •
  • MZ
Project

New approach for diagnosis of cystic fibrosis based on ion ratios in noninvasively obtained samples (NV18-08-00189)

An early diagnosis of cystic fibrosis (CF) through newborn screening programmes (NBSP) is very important to initiate the treatment, genetic counseling, and specialized medical services. NBSP consists of immunoreactive trypsinogen (IRT) analysis, DNA ...

Analytical chemistry

  • 2018 - 2021
    • •
  • 12 947 tis. Kč
    • •
  • 12 947 tis. Kč
    • •
  • MZ
Project

Activity of novel compounds against Burkholderia cenocepacia a study of genome and transcriptome in respect to bacterial evolution in the human host (NV15-28017A)

The most problematic respiratory pathogens in patients with cystic fibrosis (CF) are arguably bacteria from Burkholderia cepacia complex (Bcc) as they cause fatal infections, untreatable by current antibiotics. Recently, first promising compounds wit...

EE - Mikrobiologie, virologie

  • 2015 - 2018
    • •
  • 4 602 tis. Kč
    • •
  • 4 602 tis. Kč
    • •
  • MZ
Project

Pulmonary condensate A promising source of proteomic biomarkers for non-invasive evaluation of pulmonary involvement in asthma and cystic fibrosis. (NV16-32302A)

Exhaled breath condensate (EBC) represents a rich source for countless biomarkers that can provide valuable information about respiratory as well as systemic diseases. Finding non-invasive methods for early detection of lung injury, inflamation and i...

EB - Genetika a molekulární biologie

  • 2016 - 2019
    • •
  • 7 911 tis. Kč
    • •
  • 7 911 tis. Kč
    • •
  • MZ
Project

Optimization of cystic fibrosis patient-derived cellular models to asses restoration of CFTR function in patients with cystic fibrosis (NU23-07-00079)

The discovery of modulators that target cystic fibrosis transmembrane conductance regulator (CFTR) protein has opened the era of cystic fibrosis (CF) curative treatment. Although this therapy is termed mutation specific, strikingly a level of therape...

Paediatrics

  • 2023 - 2026
    • •
  • 15 195 tis. Kč
    • •
  • 15 195 tis. Kč
    • •
  • MZ
Project

Identification and validation of cyst fluid biomarkers discriminating low grade, high grade and invasive intraductal papillary mucinous neoplasm of the pancreas (NU23J-06-00043)

Pancreatic cancer is one of the deadliest malignant diseases worldwide. In the Czech Republic, it is responsible for more than 2200 deaths per year, and the age-adjusted death rate is the third highest in the world. In a nonnegligible fraction of cas...

Biochemistry and molecular biology

  • 2023 - 2026
    • •
  • 6 304 tis. Kč
    • •
  • 6 304 tis. Kč
    • •
  • MZ
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