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Projects

143 projects (0,122s) •

Project

Cytostatics - robotic workstation (EG16_084/0010339)

Cytostatics - robotic workstation...

JC - Počítačový hardware a software

  • 2017 - 2020
    • •
  • 13 322 tis. Kč
    • •
  • 9 325 tis. Kč
    • •
  • MPO
Project

Active dosing of cytostatics (EG15_018/0004617)

Active dosing of cytostatics...

FD - Onkologie a hematologie

  • 2015 - 2020
    • •
  • 4 212 tis. Kč
    • •
  • 1 411 tis. Kč
    • •
  • MPO
Project

Potentiation of cytostatics effects by valproic acid (NR9522)

HDAC inhibitors enhance anticancer effect of some cytostatics.The aims: 1/ to determine which cytostatics are potentiate by VPA; 2/contribute to knowledge of cytostatics. Mechanisms of potentiation of cytostatics by VPA we ...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 6 113 tis. Kč
    • •
  • 6 113 tis. Kč
    • •
  • MZ
Project

Intracellular and extracellular targets for antitumor activity and toxicity of ruthenium complexex (1P05OC070)

complexex of rhutenium as a new class of promising cytostatics effective in tumor cell resistant to platinum cytostatics...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2006
    • •
  • 705 tis. Kč
    • •
  • 522 tis. Kč
    • •
  • MŠMT
Project

Influence of metallothionein on binding of platinum cytostatics to DNA in cancer cells (NV15-28334A)

The objective of the project is to study the binding of platinum cytostatics cytostatics, as well as carrying MTs and/or zinc ions that can modulate the response of cancer cells to treatment with platinum cytostatics will b...

FD - Onkologie a hematologie

  • 2015 - 2019
    • •
  • 15 620 tis. Kč
    • •
  • 15 620 tis. Kč
    • •
  • MZ
Project

Measurement of the concentration of cytostatics in the vitreous cavity of rabbits eye ball after trancorneal and subconjunctival administration (NR9532)

Local administration of cytostatics into the vitreous cavity of rabbits eyes ball via transcorneal way followed by measurement of vitreous concentration according various time schedule. Measurement of toxic effects of cytostatics on...

FF - ORL, oftalmologie, stomatologie

  • 2007 - 2009
    • •
  • 1 856 tis. Kč
    • •
  • 1 856 tis. Kč
    • •
  • MZ
Project

New cytostatic agents-problems of their cardiotoxicity and potential cardiopotective activity. (IZ4212)

Study of cardiotoxicity and potential cardioprotective effects of new cytostatic drugs (benzo/c/fluorens, Oracin) using approaches of quantal-chemistry, cardiovascular pharmacology, toxicology, biochemistry and morphology in animals in vivo ...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 1997 - 1999
    • •
  • 1 290 tis. Kč
    • •
  • 1 026 tis. Kč
    • •
  • MZ
Project

Sensitisation of B-CLL cells to cytostatics by monoclonal antibody rituximab - identification of responsible proteins (NR9301)

effect of monoclonal antibody rituximab in relation to cytostatics is not determined it is not reasonable to apply rituximab in connection to corresponding cytostatics.......

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 1 785 tis. Kč
    • •
  • 1 507 tis. Kč
    • •
  • MZ
Project

The development of ruthenium antitumor compounds (OC D8.50)

Although cytostatics derived mainly from the platinum complexes are used at present in chemotherapy of tumors, the number of tumors sensitive to these cytostatics is limited. It was shown recently that among metal complexes for whic...

FR - Farmakologie a lékárnická chemie

  • 1998 - 2001
    • •
  • 6 030 tis. Kč
    • •
  • 1 180 tis. Kč
    • •
  • MŠMT
Project

Cytostatic hetero-fused 7-deazapurine nucleosides, pharmacology, metabolism and mechanism of action. (GA19-08124S)

Recently we discovered that hetero-fused 7-deazapurine nucleosides exert nanomolar cytostatic activity, but their biological target and mechanism of action are unknown. Therefore, we propose to synthesize other analogues and derivatives, sys...

Medicinal chemistry

  • 2019 - 2021
    • •
  • 11 465 tis. Kč
    • •
  • 11 123 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 143