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17 (0,165s) •

Project

Membrane signalosomes of mast cells and basophils - targets for innovative therapies (LD12073)

The aim of this project is: 1. To contribute to determining the composition of the FceRI membrane signalosomes important for antigen-induced degranulation in mast cells. 2. To contribute to determining the composition of membrane signalosome...

EC - Imunologie

  • 2012 - 2014
    • •
  • 1 500 tis. Kč
    • •
  • 1 500 tis. Kč
    • •
  • MŠMT
Project

Immune reactions in food hypersensitivity and possibilities of their modulation (NI5467)

Development of mouse model of food hypersensitivity. Antiallergen antibody detection. Testing of blast transformation, cytokine formation and mast cell degranulation after stimulation by allergen.Modulation of hypersensitivity by oral tolera...

EC - Imunologie

  • 1999 - 2001
    • •
  • 1 864 tis. Kč
    • •
  • 1 864 tis. Kč
    • •
  • MZ
Project

Microtubules in activated mast cells - targets for innovative therapies (LD13015)

degranulation and chemotaxis in mast cells of mouse and human origin....

EC - Imunologie

  • 2013 - 2014
    • •
  • 942 tis. Kč
    • •
  • 942 tis. Kč
    • •
  • MŠMT
Project

Molecular biological perspectives of the pharmacological modulation of the activation of professional phagocytes (MEB0810013)

Activation of tissue and blood phagocytes results in a production of reactive oxygen species during the oxidative stress. The response of professional phagocytes after their activation may be diminished by many drugs, natural compounds and endogenous...

FR - Farmakologie a lékárnická chemie

  • 2010 - 2011
    • •
  • 86 tis. Kč
    • •
  • 86 tis. Kč
    • •
  • MŠMT
Project

Cypress pollen allergy biological, physicochemical and immunochemical characterization of the marker of sensitization to Cupressus sempervirens, BP14 (7AMB15FR013)

The goals of this project are to structurally characterize and elucidate the clinical relevance of BP14 in relation to degranulation of basophils and mast cells. The study of the involvement of anti BP14 IgE reactivity in the peach/cypress o...

EC - Imunologie

  • 2015 - 2016
    • •
  • 108 tis. Kč
    • •
  • 108 tis. Kč
    • •
  • MŠMT
Project

The role of cytoskeleton in mast cell activation (IAA5052704)

Crosslinking of the high affinity receptor for IgE (FceRI) on the surface of mast cells and basophils initiates a series of biochemical events culminating in degranulation and release of mediators of allergic reactions. Early events include ...

EC - Imunologie

  • 1997 - 1999
    • •
  • 2 814 tis. Kč
    • •
  • 1 694 tis. Kč
    • •
  • AV ČR
Project

Antioxidative properties of flavonoids with respect to the oxidative burst of phagocytes and cooperation between phagocytes and endothelial cells (IAB6004204)

(chemiluminometrically and flow-cytometrically), and degranulation (spectrophotometricaldetermination...

ED - Fyziologie

  • 2002 - 2004
    • •
  • 3 395 tis. Kč
    • •
  • 1 609 tis. Kč
    • •
  • AV ČR
Project

Antimicrobial peptides from insects for possible therapeutic applications (GA203/08/0536)

degranulation, hemolysis and chemotaxis. Depending upon the results of bioassays and NMR...

CC - Organická chemie

  • 2008 - 2010
    • •
  • 3 957 tis. Kč
    • •
  • 3 957 tis. Kč
    • •
  • GA ČR
Project

Regulatory role of TEC-21 membrane in mast cell activation (GA204/00/0204)

in the inhibitory action of TEC-21 aggregation on antigen-stimulated degranulation response...

EB - Genetika a molekulární biologie

  • 2000 - 2002
    • •
  • 2 650 tis. Kč
    • •
  • 2 170 tis. Kč
    • •
  • GA ČR
Project

Calcium signaling to microtubules in activated mast cells (GA16-25159S)

Mast cells play a pivotal role in innate immunity, allergy and inflammation. Antigen-induced activation of mast cells leads to rapid cytoskeleton rearrangement and degranulation. Previously we have shown that activation results in generation...

EA - Morfologické obory a cytologie

  • 2016 - 2018
    • •
  • 6 075 tis. Kč
    • •
  • 5 781 tis. Kč
    • •
  • GA ČR
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