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Projects

12 projects (0,113s) •

Project

Therapy of demyelinating disorders of the CNS using neural stem cells (NR7969)

Therapeutic potential of stem cells can be used to treat those disorders that can not be healed with conventional approaches. Project is aimed at evaluation of remyelination potential of neural stem cells in therapy of progressing demyelinating

EA - Morfologické obory a cytologie

  • 2004 - 2006
    • •
  • 1 790 tis. Kč
    • •
  • 1 639 tis. Kč
    • •
  • MZ
Project

New types of visual evoked potentials for functional diagnostics of central nervous system (NR8421)

, dementias, demyelination and cognitive changes....

FH - Neurologie, neurochirurgie, neurovědy

  • 2005 - 2008
    • •
  • 1 226 tis. Kč
    • •
  • 1 218 tis. Kč
    • •
  • MZ
Project

Autosomal recessive demyelinating neuropathy type CMT4C ? analysis of the SH3TC2 gene and a clinical study. (NT11521)

Defects in the SH3TC2 gene have been recently identified in patients with hereditary motor and sensory neuropathy (HMSN). Patients cohort of about 120 urelated individuals with the demyelinating hereditary neuropathy and pedigrees compatible...

FH - Neurologie, neurochirurgie, neurovědy

  • 2010 - 2013
    • •
  • 3 846 tis. Kč
    • •
  • 3 846 tis. Kč
    • •
  • MZ
Project

The role of neurosteroids in the etiopathogenesis of multiple sclerosis (NT13814)

In serum and cerebrospinal fluid of 60 patients with MS (40 women in the both phases of the menstrual cycle and 20 men) the steroid metabolom will be investigated. Levels of steroid hormones in serum and cerebrospinal fluid will be monitored as well ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2012 - 2015
    • •
  • 4 302 tis. Kč
    • •
  • 4 302 tis. Kč
    • •
  • MZ
Project

Principal signaling pathways regulating NG2 glia proliferation and differentiation following brain injuries (GA17-04034S)

stab wound and demyelination. To manipulate the output of Wnt or Shh signaling...

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2019
    • •
  • 12 507 tis. Kč
    • •
  • 11 937 tis. Kč
    • •
  • GA ČR
Project

Diffusion parameters in the brain and spinal cord during injury (GA309/99/0657)

Changes in extracellular space (ECS) ionic composition, volume and geometry are a consequence of neuronal activity, seizures, ischemia/anoxia, demyelination, inflammation and many other pathological states in the CNS and may significantly af...

FH - Neurologie, neurochirurgie, neurovědy

  • 1999 - 2001
    • •
  • 3 521 tis. Kč
    • •
  • 2 953 tis. Kč
    • •
  • GA ČR
Project

Cellular microvesicles as a diagnostic marker in multiple sclerosis (NV15-32961A)

Multiple sclerosis is chronic inflammatory disease of central nervous system. Dysregulation of immune system, migration of immune cells across blood brain barrier and their participation in development demyelinating lesions play pivotal role...

FH - Neurologie, neurochirurgie, neurovědy

  • 2015 - 2019
    • •
  • 14 956 tis. Kč
    • •
  • 14 956 tis. Kč
    • •
  • MZ
Project

Hormonal alterations in patients with multiple sclerosis (NU20-04-00450)

Multiple sclerosis (MS) is a frequent inflammatory autoimmune and demyelination disease of the central nervous system (CNS), progressing for decades, seriously jeopardizing health status and resulting in disability. Mechanisms involved in MS...

Clinical neurology

  • 2020 - 2024
    • •
  • 6 766 tis. Kč
    • •
  • 6 508 tis. Kč
    • •
  • MZ
Project

Unraveling the role of ileal microbiota in the pathogenesis of multiple sclerosis (GA17-07332S)

Multiple sclerosis (MS) is a devastating chronic disorder of the central nervous system which affects 2.5 million people worldwide. It is an autoimmune disorder characterized by nerve demyelination. Genetic, environmental, and immunological ...

EC - Imunologie

  • 2017 - 2021
    • •
  • 5 782 tis. Kč
    • •
  • 5 758 tis. Kč
    • •
  • GA ČR
Project

Role of MARVEL domain containing proteins in the geneticly encoded stress protection (GAP302/11/0146)

MARVEL-domain family contains proteins involved in membrane apposition/fusion events in single- and multi-cellular eukaryotes from yeast to human, related to complex diseases such as demyelinating neuropathies, schizophrenia or inflammation....

EA - Morfologické obory a cytologie

  • 2011 - 2014
    • •
  • 5 423 tis. Kč
    • •
  • 5 423 tis. Kč
    • •
  • GA ČR
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