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26 619 (0,345s) •

Project

The development and maturation of porcine B cells (GAP502/10/0038)

The development of B cells in primary lymphoid tissues is not described. The direct outcomes of the project will be: 1) to resolve B cells developmental pathways in the bone marrow and characteriz...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2010 - 2014
    • •
  • 7 025 tis. Kč
    • •
  • 7 025 tis. Kč
    • •
  • GA ČR
Project

ROR1-positive peripheral blood b-cells of healthy donors and their connection to chronic lymphocytic leukemia development (GA23-05561S)

The project aims at description of frequency and phenotype of ROR1+ B cells+ B cells were described, however our data show that these populations contain also mature B cells, including memory subs...

Cell biology

  • 2023 - 2025
    • •
  • 10 232 tis. Kč
    • •
  • 10 232 tis. Kč
    • •
  • GA ČR
Project

Antibody repertoire development in fetal and neonatal piglet (ME 339)

The aim of the project is to determine the site of porcine B cell lymphogenesis, the role of different lymphoid tissues in B cell lymphogenesis and the mechanisms used in developing antibody repertoire. We...

EC - Imunologie

  • 1999 - 2002
    • •
  • 2 774 tis. Kč
    • •
  • 1 961 tis. Kč
    • •
  • MŠMT
Project

The study of B cell development in pigs (GA524/00/1280)

The aim of our project is to study the B lymphocyte development in pigs anti-pig hybridomas producing monoclonal antibodies directed against B cell and B lymphopoietic activity in primary haematopoietic si...

EC - Imunologie

  • 2000 - 2002
    • •
  • 2 581 tis. Kč
    • •
  • 2 245 tis. Kč
    • •
  • GA ČR
Project

Targeting BCR signalosome in B-cell malignancies (NV17-31834A)

The B-cell receptor (BCR) signalling pathway is tightly connected with the function, proliferation and survival of B cells. Aberrant BCR signalling, typical for various B cell malignancies, has be...

FD - Onkologie a hematologie

  • 2017 - 2020
    • •
  • 9 122 tis. Kč
    • •
  • 9 122 tis. Kč
    • •
  • MZ
Project

Characterization of thymic B cells (IAA5020303)

of ThBC develops differently from B cells arising in the bone marrow. (3) It is ourThymic B cells (ThBC) will be phenotypized using flow cytometry and localized rearrangement. (4) We also propose to test ...

EC - Imunologie

  • 2003 - 2007
    • •
  • 3 312 tis. Kč
    • •
  • 2 794 tis. Kč
    • •
  • AV ČR
Project

What cells are responsible for unselected B cell repertoire in the porcine thymus? (GA16-09296S)

of such repertoire is a fact that thymus serves as a primary lymphoid organ for T cells, and development of B cells is inhibited there. The inhibition is not mediated by suppression that the inhibition of B

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2016 - 2020
    • •
  • 6 036 tis. Kč
    • •
  • 6 036 tis. Kč
    • •
  • GA ČR
Project

Disturbances of differentiation of B-lymphocytes in patients with defects of humoral immunity (NT11414)

The Ig-specific single-cell RT-PCR in B cells of patients with CVID, IgAD/IgMD, proliferation and activation, BCR signalling and differentiation stadium of B cell subsets of these diseases, determination o...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2010 - 2014
    • •
  • 9 894 tis. Kč
    • •
  • 9 894 tis. Kč
    • •
  • MZ
Project

Characterization of T and B lymphocytes in Ileal Peyers Patches of swine. (ME09089)

conversion events and diversification of B cell repertoire is expected due to occurrence in diversification of B cell repertoire and generation of new B cells. However, our previous data indicate...

EC - Imunologie

  • 2009 - 2012
    • •
  • 3 738 tis. Kč
    • •
  • 3 738 tis. Kč
    • •
  • MŠMT
Project

The role of sphingosine-1-phosphate receptor 1 in B cell mechanosensitivity. (GA25-16907S)

of S1PR1 in B cells mechanosensing. Further, by defining the role of S1PR1 in mechanosensitivity and motility of malignant B cells, this research may lead to development confinement triggers rapid motilit...

Cell biology

  • 2025 - 2027
    • •
  • 11 919 tis. Kč
    • •
  • 11 919 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 26 619