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481 (0,086s) •

Project

The role of vasoactive humoral systems in pathogenesis of diabetic nephropathy. (NB6365)

The aims of the project are a) to test the regulation of selected vasoactive humoral systems and their role in the pathogenesis of diabetic nephropathy in type I diabetic patients and healthy subjects and b) to evalute the ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2000 - 2002
    • •
  • 6 135 tis. Kč
    • •
  • 6 135 tis. Kč
    • •
  • MZ
Project

Genetic variability of pentose phosphate pathway as a modulating factor of the onset and progression of diabetic nephropathy (NR9443)

The project aims to optimise early diagnostics of diabetic nephropathy by means of genetic analysis of transketolase and transaldolase genes and to allow individualised follow-up of diabetics and, eventually, even individua...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2009
    • •
  • 3 846 tis. Kč
    • •
  • 3 846 tis. Kč
    • •
  • MZ
Project

Cyclooxygenase-2 polymorphisms and the development of nephropathy in diabetes (NR9368)

Using molecular biological techniques we will study -765GC polymorphisms in COX-2 gene and their possible impact on monocytic COX-2 phenotype in diabetic patients with nephropathy in comparison with patients without DN and healthy s...

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 3 446 tis. Kč
    • •
  • 3 386 tis. Kč
    • •
  • MZ
Project

Possibilities of diabetic nephropathy modification and prevention of renal failure progression in diabetics. (IZ932)

9F - 9

  • 1992 - 1995
    • •
  • 235 tis. Kč
    • •
  • 470 tis. Kč
    • •
  • MZ
Project

The significance of cytokines and lipid peroxidation in the development of diabetic nephropathy (IZ3162)

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1995 - 1997
    • •
  • 818 tis. Kč
    • •
  • 790 tis. Kč
    • •
  • MZ
Project

Proteomic prediction and Renin angiotensin aldosterone system Inhibition prevention Of early diabetic nephRopathy In TYpe 2 diabetic patients with normoalbuminuria (7E12025)

Patients with diabetes are at risk of developing diabetic nephropathy, which nephropathy earlier in the preclinical phase, enabling targeted treatment at an earlier progression of albuminuria (as a surrogate marker...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2012 - 2018
    • •
  • 624 tis. Kč
    • •
  • 624 tis. Kč
    • •
  • MŠMT
Project

Renal hemodynamics in early stage of the diabetic nephropathy. (IZ2018)

9F - 9

  • 1994 - 1996
    • •
  • 569 tis. Kč
    • •
  • 819 tis. Kč
    • •
  • MZ
Project

Functional analysis of the RAGE gene susceptibility haplotype and its role in the hyperglycemia-driven pathology (KJB501620601)

of diabetic nephropathy. Based on these findings we postulate hypothesis that genetic for alteration of cellular phenotype in diabetes. We previously shown that certain haplotype variability in long-term impact of diab...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2006 - 2008
    • •
  • 563 tis. Kč
    • •
  • 563 tis. Kč
    • •
  • AV ČR
Project

Pentose phosphate pathway as a potentially new therapeutic target in prevention of diabetic complications (NT13198)

active form of thiamine in diabetics which serves as a cofactor for transketolase functional thiamine deficiency in diabetes, especially when accompanied with advanced of pentose phosphate pathway, development of diabetic ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2012 - 2015
    • •
  • 6 701 tis. Kč
    • •
  • 6 701 tis. Kč
    • •
  • MZ
Project

The expression of proinflammatory genes in patients with IgA nephropathy and their relation to the disease outcome (NR8913)

Determine correlation among intrarenal expression of MCP-1, RANTES, TGF-beta1, HGF and BMP genes, infiltration of leukocyte into renal tissue, proteinuria and short term otcome of IgA nephropathy. Find out if patients with genotype related a...

FE - Ostatní obory vnitřního lékařství

  • 2006 - 2009
    • •
  • 4 966 tis. Kč
    • •
  • 4 432 tis. Kč
    • •
  • MZ
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