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8 503 (0,134s) •

Project

Biomolecular NMR spectroscopy for rational drug design (LK11205)

The aim of the project is rational design of active compounds targeting several types of biomedicinally important enzymes using the fragment-based approach together with biomolecular NMR spectroscopy and modern methods of structural biology,...

BB - Aplikovaná statistika, operační výzkum

  • 2012 - 2016
    • •
  • 19 310 tis. Kč
    • •
  • 19 310 tis. Kč
    • •
  • MŠMT
Project

Reshaping early-stage drug discovery by Artificial Intelligence (TP04020039)

candidate drugs have a chance to meet the requirements to enter the preclinical phase. This could lead to tremendous cost and time reductions in the drug discovery pipeline) to get into contact with relevant pharma companies, and e...

Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

  • 2022 - 2022
    • •
  • 2 145 tis. Kč
    • •
  • 1 000 tis. Kč
    • •
  • TA ČR
Project

Poly(2-oxazoline)s In silico adjustment of their properties for development of drug-specific delivery systems (GA25-15646S)

informing the rational design of POx-based DDS to maximize their potential in drug to function as versatile platforms for drug delivery systems (DDS). Among these, poly(2 to their biocompatibility, adjustable properties, a...

Physical chemistry

  • 2025 - 2027
    • •
  • 12 470 tis. Kč
    • •
  • 11 423 tis. Kč
    • •
  • GA ČR
Project

Targeting the Androgen Receptor Developing Binder Molecules for Prostate Cancer Therapy and Advancing NMR-AI Platform for Enhanced Drug Design. (TM05000031)

for future cooperation. 4. Expand partnership with AnHorn for early drug discovery phase of drug discovery solutions, fostering valuable industry partnerships and contributing......

Biophysics

  • 2024 - 2025
    • •
  • 16 956 tis. Kč
    • •
  • 12 762 tis. Kč
    • •
  • TA ČR
Project

In silico drug design based on advanced semiempirical quantum mechanical methods accurately describing noncovalent interactions (GAP208/11/0295)

Develop fast and accurate methods for computer-aided design of new drugs based on semi-empirical quantum chemical methods PM6-DH2 correctly describing the various types of non-covalent interactions. Besides interaction enthalpy and ...

CF - Fyzikální chemie a teoretická chemie

  • 2011 - 2011
    • •
  • 1 000 tis. Kč
    • •
  • 1 000 tis. Kč
    • •
  • GA ČR
Project

Development of epigenetic inhibitors with anticancer activity driven by nuclear magnetic resonance and artificial intelligence (FW12010060)

enzymes. 2. Create new techs for drug development, integrate them into our NMR-AI structures and chemical shifts. 4. Strengthen AI|ffinity's drug discovery capabilities. Increase AI|ffinity's valuation through new drug c...

Biophysics

  • 2025 - 2027
    • •
  • 36 725 tis. Kč
    • •
  • 25 000 tis. Kč
    • •
  • TA ČR
Project

Non-covalent DNA recognition strategies for design and synthesis of new metallo-drugs (1P05OC072)

procural of specific and easily modifiable structures for location of group capable of noncovalent bond to DNA...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2006
    • •
  • 705 tis. Kč
    • •
  • 522 tis. Kč
    • •
  • MŠMT
Project

Structure and properties of paramagnetic ruthenium complexes for designing new anticancer drugs (GA15-09381S)

base portfolio in targeted drug design.We propose to study novel candidates for ruthenium anticancer drugs based on ruthenium complexes protected by cucurbit[n]uril and bambus[n]uril cavitands of their importance, to the n...

CF - Fyzikální chemie a teoretická chemie

  • 2015 - 2017
    • •
  • 5 685 tis. Kč
    • •
  • 5 685 tis. Kč
    • •
  • GA ČR
Project

Branched and hyperbranched polymer carriers of drugs for local therapy (IAA400500806)

, controlled release of drug and biological properties should facilitate designThe project focuses on design, synthesis and study of physicochemical and biological properties of biodegradable branched and hyperbranched poly...

CD - Makromolekulární chemie

  • 2008 - 2011
    • •
  • 6 448 tis. Kč
    • •
  • 6 448 tis. Kč
    • •
  • AV ČR
Project

Analytical tools for fast identification of new designer drugs (LH14064)

Study of analytical properties (ion mobility, ionization, fragmentation, VUV spectra) of new designer drugs belonging to cathinones and phenylethylamines represents the starting point in development of analytical methods. These meth...

CB - Analytická chemie, separace

  • 2014 - 2016
    • •
  • 1 932 tis. Kč
    • •
  • 1 932 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 8 503