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4 718 (0,168s) •

Project

Polymer conjugates of drugs targeted with specific oligopeptides (GA204/05/2255)

and biological properties of an anti-angiogenic oligopeptide-targeted polymer drug delivery systém intended for site-specific tumor therapy. The proposed polymer drug delivery systémrepresents a unique system enabling duál...

CD - Makromolekulární chemie

  • 2005 - 2007
    • •
  • 5 421 tis. Kč
    • •
  • 5 421 tis. Kč
    • •
  • GA ČR
Project

Targets for Chemotherapy and Drug Resistance in Anaerobic Protozoan Parasites (OC B22.001)

Targets for Chemotherapy and Drug Resistance in Anaerobic Protozoan Parasites...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2003 - 2006
    • •
  • 4 199 tis. Kč
    • •
  • 1 897 tis. Kč
    • •
  • MŠMT
Project

Nanoparticulate and supramolecular systems for targeted drug delivery (KAN200200651)

The aim of the project is to develop a new generation of nanopharmaceuticals, i.e. drugs and drug delivery systems both for diagnosis and nanotherapy. Validated analytical techniques are included to confirm the identity,stability an...

FR - Farmakologie a lékárnická chemie

  • 2006 - 2010
    • •
  • 93 256 tis. Kč
    • •
  • 81 256 tis. Kč
    • •
  • AV ČR
Project

Targets for chemotherapy of infections with anaerobic Protozoa rezistant to 5-nitroimidazoles (OC B9.10)

protozoan pathogens to 5-nitroimidazole drugs and to search for potential targets for therapy of nitroimidazole-resistant organisms. Drug resistance studies will focus on molecular background of downregulation of parasite ...

EE - Mikrobiologie, virologie

  • 1999 - 2002
    • •
  • 3 205 tis. Kč
    • •
  • 1 655 tis. Kč
    • •
  • MŠMT
Project

Lysosomal sequestration of tyrosine kinase inhibitors and drug resistance in cancer cells (GA17-16614S)

Targeted cancer therapy utilises rationally designed drugs that interfere resistance, defined as progression after initial benefit, to targeted therapies inevitably occurs. Mutation of the target gene that disrupts...

FR - Farmakologie a lékárnická chemie

  • 2017 - 2020
    • •
  • 5 018 tis. Kč
    • •
  • 4 948 tis. Kč
    • •
  • GA ČR
Project

Polymeric drugs actively targeted by recombinant antibody fragments as therapeutic approach in treatment of GD2 positive cancers (GA16-17207S)

on HPMA copolymers bearing cytostatic drugs (e.g. doxorubicin) and actively targeted bond between the peptide tags SpyTag/KTag) of the targeting scFv molecule. The systems are designed to achieve specific accumulation in t...

CD - Makromolekulární chemie

  • 2016 - 2018
    • •
  • 9 495 tis. Kč
    • •
  • 8 239 tis. Kč
    • •
  • GA ČR
Project

Making drugs smarter Novel conjugable phosphorus-based linkers for targeted drug delivery (GA23-05752S)

applications, and phosphorus SI linkers cannot be conjugated to ligands for targeted drug with biomolecules and protein modification while developing targeted drug delivery systemsIn drug delivery, light-...

Organic chemistry

  • 2023 - 2025
    • •
  • 6 174 tis. Kč
    • •
  • 6 174 tis. Kč
    • •
  • GA ČR
Project

Center of targeted therapeutic drugs (1M0505)

containResearch of biotransformation path ways of anti-tumour drugs in relation to their effect. Development and synthesis of new anti-tumour drugs which are well tolerant by the organism (bioconjugates, targeted drugs...

EI - Biotechnologie a bionika

  • 2005 - 2011
    • •
  • 225 617 tis. Kč
    • •
  • 200 673 tis. Kč
    • •
  • MŠMT
Project

Atomically resolved in vivo NMR spectroscopy as a novel tool for biological testing of therapeutically important genomic non-canonical DNA targets and their interactions with drugs in phenotypically (NV19-08-00450)

stranded DNAs, are important therapeutic targets for design and development of anti-cancer drugs. Currently established procedures for the identification of DNA targets and development of DNA-binding ligands/drugs...

Biochemistry and molecular biology

  • 2019 - 2022
    • •
  • 13 449 tis. Kč
    • •
  • 13 449 tis. Kč
    • •
  • MZ
Project

Hybrid magnetic "stealth" nano-structures for the targeted and controlled release of doxorubicin (7AMB12GR026)

and performance of physically targeted drug nanocarriers for cationic drugs such as doxorubicin - a potent drug but with serious side effects. Therefore, new multifunctional magneticnanocarriers for anticancer

CA - Anorganická chemie

  • 2012 - 2013
    • •
  • 114 tis. Kč
    • •
  • 114 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 4 718