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3 996 (0,104s) •

Project

Virtual decomposition of materials using dual-target X-ray computed tomography (TQ15000217)

The main aim of this project is design of the automatic changer of filters for X-ray computed nanotomograph Rigaku nano3DX. This filter changer will speed up characterization of materials using dual-target X-ray computed tomogra...

Mechanical engineering

  • 2025 - 2026
    • •
  • 2 710 tis. Kč
    • •
  • 2 240 tis. Kč
    • •
  • TA ČR
Project

Differentiation of soft tissues using dual-target tomography (TJ02000127)

In realization of proposed project Differentiation of soft tissues using dual-target tomography, an utilization of this modality will be tested for data acquisition with submicron spatial resolution and subsequent data proc...

Radiology, nuclear medicine and medical imaging

  • 2019 - 2021
    • •
  • 2 764 tis. Kč
    • •
  • 2 350 tis. Kč
    • •
  • TA ČR
Project

R1-Shadow (TP03020013)

The objectives of the presented project are targeted on the extension of the conceptually verified prototype of the multi-purpose solution for high-resolution X-ray computed tomography (CT) to the end-user's commercial utilization....

Radiology, nuclear medicine and medical imaging

  • 2021 - 2022
    • •
  • 546 tis. Kč
    • •
  • 300 tis. Kč
    • •
  • TA ČR
Project

Polymer conjugates of drugs targeted with specific oligopeptides (GA204/05/2255)

systémrepresents a unique system enabling duál drug targeting and dual therapeutic activity of the polymer drug. Dual targeting will be achieved by combination of an active targeting and biological proper...

CD - Makromolekulární chemie

  • 2005 - 2007
    • •
  • 5 421 tis. Kč
    • •
  • 5 421 tis. Kč
    • •
  • GA ČR
Project

Mobile device devoted to imaging and analysis of the layered paintings and polychromy of the works of old art (DG18P02OVV006)

combining 3D X-ray micro-profilometry and X-ray dual energy computed tomography (so and X-ray tomography can be taken as complementary methods. Laboratory tomography......

Arts, Art history

  • 2018 - 2022
    • •
  • 24 050 tis. Kč
    • •
  • 24 050 tis. Kč
    • •
  • MK
Project

Universal SEM as a multi-nano-analytic tool - UnivSEM (7E12087)

1. Removing technical barriers to reach physical limits ? UniSEM chamber design 2. Dual electron and ion beam instrument improvements: advanced SEM immersion optics and plasma FIB 3. Development of improved TOF-SIMS sensitivity and lateral a...

BH - Optika, masery a lasery

  • 2012 - 2015
    • •
  • 1 900 tis. Kč
    • •
  • 1 900 tis. Kč
    • •
  • MŠMT
Project

Mechanistic studies on dual targeting of DNA and histone deacetylase with bifunctional inhibitors (GA14-21053S)

capable of dual targeting of histone deacetylase and DNA, the cytotoxicity, selective targeting to cancer cells, DNA binding, cellular accumulation, HDAC inhibitory activity are to explore novel approaches to drug targ...

CE - Biochemie

  • 2014 - 2016
    • •
  • 5 599 tis. Kč
    • •
  • 5 599 tis. Kč
    • •
  • GA ČR
Project

Targeting resistance to chemotherapy of tumor cells to reinstate their susceptibility to novel, existing and unsuccessful anticancer metallodrugs (GA18-09502S)

) as one of the targets of their action will be introduced and tested. New combinations of metallodrugs and molecules targeting cancer resistomes capable of dual targeting of anticancer metallodrugs and agents capa...

Medicinal chemistry

  • 2018 - 2020
    • •
  • 6 180 tis. Kč
    • •
  • 5 568 tis. Kč
    • •
  • GA ČR
Project

Dual FLT3/CDK9 inhibition as a possible therapeutical approach for mixed lineage leukemia (GA19-09086S)

oncogenic MLL and FLT3. In this project we intend to explore dual FLT3/CDK9 targeting regulators including CDK9 on target gene loci. Besides that, MLL-rearranged leukemias often express oncogenic forms of FLT3 kinase. We r...

Oncology

  • 2019 - 2023
    • •
  • 9 576 tis. Kč
    • •
  • 9 576 tis. Kč
    • •
  • GA ČR
Project

Targeting of FLT3 using new dual inhibitors as a therapeutic approach in MLL-rearranged acute myeloid leukemia (GA23-05462S)

, the compounds target few other kinases and in this project we intend to explore dual FLT3 inhibitors induce acquired drug resistance and therefore new compounds with rational dual......

Medicinal chemistry

  • 2023 - 2025
    • •
  • 11 998 tis. Kč
    • •
  • 11 998 tis. Kč
    • •
  • GA ČR
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