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13 (0,143s) •

Project

In-depth analysis of the function and regulatory potential of individual subunits of human translation initiation factor 3 and their subcomplexes. (GA17-06238S)

mechanism has being extensively studied. The multisubunit initiation factor eIF3 and biochemical assays, we plan to investigate functions of individual eIF3 subunits expression of eIF3 subunits and other mRNAs targeted by ...

EB - Genetika a molekulární biologie

  • 2017 - 2019
    • •
  • 7 476 tis. Kč
    • •
  • 7 476 tis. Kč
    • •
  • GA ČR
Project

Structure and function of the human translation initiation factor 3 (eIF3) and its associated eIFs. (GA14-05394S)

mechanism has being extensively studied. The multisubunit initiation factor eIF3 applies mainly to human eIF3. Here we plan to analyze the structure of yeast eIF3 map of human eIF3 and to functionally characterize...

EB - Genetika a molekulární biologie

  • 2014 - 2016
    • •
  • 7 395 tis. Kč
    • •
  • 7 395 tis. Kč
    • •
  • GA ČR
Project

Role of cytoskeletal interactions of the translation initiation factor eIF3 in yeast morphogenesis (GA204/02/1424)

subunit of the translation initiation factor eIF3. We found that besides the interactions with other eIF3 subunits it localizes to microtubules and physically interacts analysis of the cytoskeletal interactions of Rpg1p and the

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 3 817 tis. Kč
    • •
  • 2 770 tis. Kč
    • •
  • GA ČR
Project

Global and transcript-specific analysis of translational control in disease. (GX19-25821X)

example is the multitasking, multisubunit eIF3. To elucidate its involvement in oncogenesis, we will investigate all translatome changes in cells where eIF3 levels were will study mechanics of ATF4 translation control under various...

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 45 840 tis. Kč
    • •
  • 45 840 tis. Kč
    • •
  • GA ČR
Project

eIF3 at the Tip of the AUG Recognition Process in Humans (GA24-10013S)

multisubunit eIF3 and its associated eIFs contribute to stringent selection of the TIS...

Biochemistry and molecular biology

  • 2024 - 2026
    • •
  • 13 443 tis. Kč
    • •
  • 13 443 tis. Kč
    • •
  • GA ČR
Project

Deciphering molecular details of the stringent decoding of the AUG start codon during eukaryotic translation initiation. (GAP305/10/0335)

the multisubunit eIF3 contributes to this intricate process on the molecular level using revealed that specific mutations in the three mutually interacting eIF3 subunits (a, b that the latter subunits comprise a self-operating ...

EB - Genetika a molekulární biologie

  • 2010 - 2014
    • •
  • 7 008 tis. Kč
    • •
  • 7 008 tis. Kč
    • •
  • GA ČR
Project

Interactions between cytoskeleton and translation machinery in yeast (GA204/99/1531)

During our studies on microtubule-interacting proteins, we have identified a new essential gene RPG1 of Saccharomyces cerevisiae encoding the largest subunit of the translation initiation factor eIF3. Using immunofluorescence we have localis...

CE - Biochemie

  • 1999 - 2001
    • •
  • 3 346 tis. Kč
    • •
  • 2 707 tis. Kč
    • •
  • GA ČR
Project

Analysis of Rpg1p interactions by confocal laser scanning microscopy and their role in initiation of protein synthesis in Saccharomyces cerevisiae (ME 222)

RPG1 is an essential gene of budding yeast Saccharomyces cerevisiae encoding a 110kDa protein required for passage through G1 phase (Kovarik, Hašek, Valášek, Ruis, Current Genetics - in press) and homologous to the large subunit (p170) of the mammali...

EA - Morfologické obory a cytologie

  • 1998 - 1999
    • •
  • 322 tis. Kč
    • •
  • 52 tis. Kč
    • •
  • MŠMT
Project

The role of translation initiation factors in transcripts sequestration and activation in the male germline of angiosperm plants (GA18-02448S)

initiation factor 3 (eIF3) serving as the key scaffold for the assembly...

Plant sciences, botany

  • 2018 - 2021
    • •
  • 9 333 tis. Kč
    • •
  • 8 652 tis. Kč
    • •
  • GA ČR
Project

Functional Organisation of the Cell (LC545)

of eIF3 translation complex participate in localized translation and dynamics...

EA - Morfologické obory a cytologie

  • 2005 - 2011
    • •
  • 131 084 tis. Kč
    • •
  • 96 589 tis. Kč
    • •
  • MŠMT
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