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3 096 (0,209s) •

Project

Actions of Bordetella pertussis effector protein BteA in respiratory epithelia (GA21-05466S)

secretion system (T3SS) to inject BteA effector protein into the cells of the mammalian hosts. However, there is little understanding of the role of BteA effector that BteA-induced modulation of ...

Cell biology

  • 2021 - 2023
    • •
  • 9 724 tis. Kč
    • •
  • 9 724 tis. Kč
    • •
  • GA ČR
Project

Mechanisms of action of Bordetella type III secretion effector BteA (GJ18-16772Y)

mechanisms underlying the action of BteA effector protein by applying an array of genetic track and modulation of host immune responses. To date, BteA is the only identified T3SS effector. In the host cel...

Microbiology

  • 2018 - 2021
    • •
  • 8 081 tis. Kč
    • •
  • 8 081 tis. Kč
    • •
  • GA ČR
Project

Fungal effectors manipulating plant defence system (GA13-26798S)

plant defences. They achieve suppression through the deployment of effector proteins. The project is aimed at the role of both protein effectors and phytohormones produced and knockdown lines. Protein

GF - Choroby, škůdci, plevely a ochrana rostlin

  • 2013 - 2019
    • •
  • 7 149 tis. Kč
    • •
  • 7 149 tis. Kč
    • •
  • GA ČR
Project

Immunological and molecular study of the effector phase of apoptosis of leukemia and myeloma cells. (NC6668)

Study of the effectors phase of apoptosis of leukemic cells in long term cultures by the use of monoclonal antibodies. Optimalisation of the "in vitro" model of leukemia cell apoptosis. Immunological and biocemical characterization of pr...

FD - Onkologie a hematologie

  • 2001 - 2003
    • •
  • 3 176 tis. Kč
    • •
  • 2 942 tis. Kč
    • •
  • MZ
Project

Role of receptor/G protein preassembly in G protein signaling (GJ20-09628Y)

GPCRs, G proteins and effectors are transported to the same endosomes. Therefore, we protein subunits, effectors and signal regulators. Our extensive experienceG proteins and G protein-coupled re...

Biophysics

  • 2020 - 2022
    • •
  • 4 908 tis. Kč
    • •
  • 4 875 tis. Kč
    • •
  • GA ČR
Project

Interactions between nuclear and nucleolar proteins controlling cell proliferation and apoptosis effectors during leukemogenesis and therapy of leukemias. (NS9637)

Study of interactions between nuclear and nucleolar factors controlling cell proliferation and effectors of programmed cell death. Modifications and translocations during leukemogenesis and drug induced apoptosis in normal leukocytes and leu...

FD - Onkologie a hematologie

  • 2008 - 2011
    • •
  • 7 084 tis. Kč
    • •
  • 7 008 tis. Kč
    • •
  • MZ
Project

Study of structural and binding properties of TRPM channels (GA17-04236S)

which directly interacts with many different effector proteins. The enormous diversity of PIP2 effector proteins allow PIP2 signaling to control a broad range intracellular N- and C-termini of TRPM channels. Fusio...

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2018
    • •
  • 4 246 tis. Kč
    • •
  • 3 747 tis. Kč
    • •
  • GA ČR
Project

Interaction of Rab GTPases with their effector complex exocyst in Arabidopsis thaliana (KJB600380806)

Rab GTPases are currently extensively studied as important regulators of the intracellular vesicular transport. The interest becomes to be focused also on proteins moderating activity of Rab GTPases and their effector proteins

ED - Fyziologie

  • 2008 - 2009
    • •
  • 840 tis. Kč
    • •
  • 840 tis. Kč
    • •
  • AV ČR
Project

Dynamics of CD161 antigen expression on cytotoxic cells and involved signaling pathways upon saccharide ligand interaction (IAA500200620)

effector function (NK, NKT, monocytes). Our previous findings demonstrated structure. We plan to assess the dynamics of CD161 protein expression upon interaction-proteins, and their possible crosstalk with Src family kinas...

EC - Imunologie

  • 2006 - 2010
    • •
  • 4 340 tis. Kč
    • •
  • 4 340 tis. Kč
    • •
  • AV ČR
Project

Multiscale analysis of signalling phospholipids and their interaction protein partners in the regulation of plant tip growth (GA13-19073S)

in cooperation with PIP2 as localization cues, which recruit their effector proteins and PIP2-effector proteins and by combining diverse experimental and computational approaches we will characterize lipid-pro...

EB - Genetika a molekulární biologie

  • 2013 - 2016
    • •
  • 7 272 tis. Kč
    • •
  • 7 272 tis. Kč
    • •
  • GA ČR
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