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18 (0,062s) •

Project

New metabolic pathways of lipid trafficking (LUAUS24040)

through endosomes using alkyne-azide click chemistry. 1.2 Investigate ceramide synthesis in endosomes, their composition and role in endosome sorting. 1.3 Define......

Biochemistry and molecular biology

  • 2024 - 2027
    • •
  • 10 122 tis. Kč
    • •
  • 10 122 tis. Kč
    • •
  • MŠMT
Project

Role of receptor/G protein preassembly in G protein signaling (GJ20-09628Y)

the recently discovered “second wave” of GPCR signaling from endosomes. The mechanism and significance of endosomal signaling itself remain poorly understood, e.g. it is unclear how GPCRs, G proteins and effectors are transported t...

Biophysics

  • 2020 - 2022
    • •
  • 4 908 tis. Kč
    • •
  • 4 875 tis. Kč
    • •
  • GA ČR
Project

Studies of GPCR and G-protein localization in membrane domains using single-molecule imaging (LTC20074)

to form the megaplex can specifically recruit their cognate G proteins to endosomes...

Physiology (including cytology)

  • 2020 - 2023
    • •
  • 3 987 tis. Kč
    • •
  • 3 987 tis. Kč
    • •
  • MŠMT
Project

Novel Generation of Polymer Drug Carrier Systems for Site-specific Therapy (IAA4050201)

cells. The drug can be activated after its release from the carrier in endosomes - 5,5in endosomes). The project envisages attachment of a specific anticancer drug......

CD - Makromolekulární chemie

  • 2002 - 2006
    • •
  • 11 639 tis. Kč
    • •
  • 4 846 tis. Kč
    • •
  • AV ČR
Project

Study of the endocytotic machinery via modification of viral-based nanoparticles (GA17-11397S)

in order to enhance a release of particles from endosomes/ lysosomes or endoplasmic...

EA - Morfologické obory a cytologie

  • 2017 - 2021
    • •
  • 8 082 tis. Kč
    • •
  • 7 950 tis. Kč
    • •
  • GA ČR
Project

Characterization of protein binding factors for porcine reproductive and respiratory syndrome virus and differentiation of Czech strains by RFLP (GP524/01/P130)

in attachment of the virus to the cells and/or fusion of viral envelope with endosome...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2001 - 2003
    • •
  • 205 tis. Kč
    • •
  • 205 tis. Kč
    • •
  • GA ČR
Project

The role of actin cytoskeleton in lytic degradation of auxin plasma membrane carriers (GJ19-13375Y)

their internalization and endosomal trafficking is regulated, using various biochemical...

Biochemistry and molecular biology

  • 2019 - 2021
    • •
  • 4 928 tis. Kč
    • •
  • 4 928 tis. Kč
    • •
  • GA ČR
Project

Role of Na/H antiporters in cell physiology - transporters teamwork in intracellular pH and K+ homeostasis (IAA500110801)

Na+/H+ antiporters serve in all organisms mainly to maintain intracellular homeostasis of alkali metal cations and pH. In the model yeast Saccharomyces cerevisiae, three members of the family exist: Nha1p is in the plasma membrane, Kha1 in the Golgi ...

EB - Genetika a molekulární biologie

  • 2008 - 2012
    • •
  • 4 020 tis. Kč
    • •
  • 4 020 tis. Kč
    • •
  • AV ČR
Project

Mechanisms of intracellular trafficking and polar targeting of auxin efflux facilitators. (KJB600380604)

undergo constitutive cycling between plasma membrane and endosomal space...

ED - Fyziologie

  • 2006 - 2008
    • •
  • 2 924 tis. Kč
    • •
  • 2 924 tis. Kč
    • •
  • AV ČR
Project

Cytoskeletal proteins mediating targeted deposition of auxin transporters (GPP305/11/P797)

and endosomal space. Although some evidences support the idea of differential actin...

EA - Morfologické obory a cytologie

  • 2011 - 2015
    • •
  • 1 799 tis. Kč
    • •
  • 1 799 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 18