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Projects

11 115 projects (0,148s) •

Project

Structural studies of beta-galactosidase from psychrotrophic microorganisms; analysis of biologically and technologically significant complexes (KJB500500512)

far unique 3D structure of this enzyme determined in the applicant's laboratory the temperature profile of the enzyme and its stability. X-ray structural analysis willbe used for these enzymes will be exp...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 1 971 tis. Kč
    • •
  • 1 971 tis. Kč
    • •
  • AV ČR
Project

Chitinolytic enzymes from Clostridium paraputrificum inhabiting the human gastrointestinal tract; structure and biomedical implications. (GA310/09/1407)

, inhibition and structural properties of the enzymes. Fundamental results with impact tract of humans is involved in food digestion by secretion of chitinolytic enzymes which are not expressed by human cells. These enz...

EE - Mikrobiologie, virologie

  • 2009 - 2013
    • •
  • 8 074 tis. Kč
    • •
  • 8 074 tis. Kč
    • •
  • GA ČR
Project

Study on structure-function relationship of cytochromes P450 - key enzymes involved in drug metabolism and carcinogen activation (GA303/06/0928)

investigating the native structure of enzyme as well as their metabolic activities will be used. Research strategy of the enzyme structure is based on application of chemical to provide structural informa...

CE - Biochemie

  • 2006 - 2008
    • •
  • 3 971 tis. Kč
    • •
  • 3 971 tis. Kč
    • •
  • GA ČR
Project

Synthesis of compounds affecting mitochondrial enzymes as potential drugs for Alzheimer disease (LD14009)

studying the modulator-enzyme interactions and structure-activity relationship modelling and structure-activity relationship determination of novel modulators of mitochondrial enzymes. These compounds have potenti...

CC - Organická chemie

  • 2014 - 2015
    • •
  • 1 364 tis. Kč
    • •
  • 1 364 tis. Kč
    • •
  • MŠMT
Project

Effects of Macromolecular Crowding on Enzyme Structure and Kinetics (GA21-15936S)

of crowding agents on the structure, stability, and activity of these enzymes. compact conformations, enzyme kinetics, etc. We will focus on three enzymes: yeast simulations, we will study these enzymes i...

Biophysics

  • 2021 - 2024
    • •
  • 5 651 tis. Kč
    • •
  • 5 651 tis. Kč
    • •
  • GA ČR
Project

Structure-functional Relationships of Haloalkane Dehalogenases (GAP207/12/0775)

compounds to corresponding alcohols. Until now, only four tertiary structures of these enzymes have been solved by X-ray analysis. Structures of several novel enzymesHaloalkane dehalogenases (EC 3.8.1.5) are micro...

CD - Makromolekulární chemie

  • 2012 - 2016
    • •
  • 12 225 tis. Kč
    • •
  • 12 225 tis. Kč
    • •
  • GA ČR
Project

Investigation of intramolecular dynamics of enzymes and polypeptides in immobilized state by radiospectroscopy methods (ME 097)

structure of studied polypeptides and protein. Analysis of the relation between the structure and internal dynamics in enzymes.......

BO - Biofyzika

  • 1997 - 1999
    • •
  • 1 122 tis. Kč
    • •
  • 822 tis. Kč
    • •
  • MŠMT
Project

Chemical biology with inhibotrs of digestive enzymes of mites Searching of tools useful in suppression, detection and chemical biology of mites Acari Acaridida (OC10019)

The aim of this project is to discover target enzyme and inhibitor useful in detection, chemical biology and suppression of mites....

EI - Biotechnologie a bionika

  • 2010 - 2012
    • •
  • 1 500 tis. Kč
    • •
  • 1 500 tis. Kč
    • •
  • MŠMT
Project

Structure and function of proteins for biotechnologies and drug design (LG14009)

The project goal is to elucidate, in collaboration with the European infrastructure Instruct, principles of function of selected target enzymes and receptors based on structural studies, to design protein modifications for the purpo...

EB - Genetika a molekulární biologie

  • 2014 - 2016
    • •
  • 7 755 tis. Kč
    • •
  • 7 755 tis. Kč
    • •
  • MŠMT
Project

Functionalized boron clusters as viral enzyme inhihitors (IAAX00320901)

syntheses of structurally optimized inhibitors of HIV-PR based on a wide-range able to inhibit a range of structurally different mutant forms and that are selectively inhibitors. An integral part of this proposal is the structu...

CA - Anorganická chemie

  • 2009 - 2013
    • •
  • 13 652 tis. Kč
    • •
  • 13 652 tis. Kč
    • •
  • AV ČR
  • 1 - 10 out of 11 115