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10 (0,087s) •

Project

Enzymes for lignocellulose biorefineries from saprotrophic fungi (OC08050)

The project is focused on the use of saprotrophic fungi for the production of enzymes applicable for lignocellulose transformation in biorefineries. Among these, mainly hydrolytic enzymes decomposing cellulose, hemicelluloses and pectin, esterase...

EI - Biotechnologie a bionika

  • 2008 - 2011
    • •
  • 1 750 tis. Kč
    • •
  • 1 750 tis. Kč
    • •
  • MŠMT
Project

Influence of the nerve agent and reactivators of Acetyl Choline Esterase on the Guinea Pig (OVUOFVZ200905)

The aim of this project is determine the physiological activity of Acetyl Choline Esterase (AChE) and detection of LD50 of inhibitors paraoxon, tabun, cyklosarine and reactivators AChE pralidoxim, obidoxim, trimedoxim, HI-6, methoxim. Next t...

FP - Ostatní lékařské obory

  • 2009 - 2011
    • •
  • 2 384 tis. Kč
    • •
  • 894 tis. Kč
    • •
  • MO
Project

NEW TECHNOLOGIES FOR PERSONAL DETECTOR OF CHOLINE ESTERASE INHIBITORS (VI20152018024)

The main objective of the project is to use industrial research to acquire new biochemical methods and advanced materials technologies, which in turn allow to design, develop, and as soon as possible industrially to produce a new type of personal det...

CB - Analytická chemie, separace

  • 2015 - 2018
    • •
  • 9 830 tis. Kč
    • •
  • 9 067 tis. Kč
    • •
  • MV
Project

Synthesis of sirtuin inhibitors (LD14128)

of their stability towards esterases. Bisphosphonate linkage instead of pyrophosphate should...

CC - Organická chemie

  • 2014 - 2016
    • •
  • 1 462 tis. Kč
    • •
  • 1 462 tis. Kč
    • •
  • MŠMT
Project

Methods of mobile analysis of the chemical warfare agents (MO03011100005)

The aim of the project is the investigation of methods of analysis of chemical warfare agents in war conditions by means of mobile equipments of chemical corps. The UV/VIS spectrophotometric procedures, originated from chromogenic chemical and bioche...

KA - Vojenství

  • 2000 - 2003
    • •
  • 5 990 tis. Kč
    • •
  • 5 990 tis. Kč
    • •
  • MO
Project

Center of Biocatalysis and Biotransformation (LC06010)

The aim of the project is to develop and optimize novel biocatalysts (dehalogenases, esterases, nitrilases, amidases, glycosidases etc.), to study their molecular structure and biocatalysis mechanisms and to introduce methods for their struc...

CE - Biochemie

  • 2006 - 2011
    • •
  • 69 815 tis. Kč
    • •
  • 69 708 tis. Kč
    • •
  • MŠMT
Project

Identification and isolation of new secondary metabolites with anti-inflammatory and anti-apoptotic features from actinomycetes. (2B06154)

The aim of the project is to isolate and to characterise new compounds related to manumycin-type metabolites. Significant enzyme-inhibitory activities of these compounds have already been reported (inhibition of Ras farnesyl transferase, caspase-1, n...

EE - Mikrobiologie, virologie

  • 2006 - 2011
    • •
  • 16 799 tis. Kč
    • •
  • 15 119 tis. Kč
    • •
  • MŠMT
Project

Hybrid structures based on Amiridine as potential multitarget drugs for Alzheimer's disease treatment (GC20-29633J)

esterase profile neuroprotective and disease-modifying properties (antioxidant, anti...

Pharmacology and pharmacy

  • 2020 - 2022
    • •
  • 4 809 tis. Kč
    • •
  • 4 809 tis. Kč
    • •
  • GA ČR
Project

Synergistic Strategies Multitarget Hybrid Drugs Addressing Neurodegeneration in Alzheimer’s Disease (GF25-18949L)

This project aims to develop dual/hybrid agents to address the multifaceted pathophysiology of Alzheimer's disease (AD) through a multitarget approach. Our strategy involves covalently conjugating optimized O-GlcNAcase (OGA) inhibitors, selected from...

Organic chemistry

  • 2025 - 2028
    • •
  • 7 938 tis. Kč
    • •
  • 7 938 tis. Kč
    • •
  • GA ČR
Project

Study of Enzymes Involved in the Biosynthesis of Pheromones of Model Species of Bumblebees (GA203/09/1446)

. lucorum (mainpheromonal component is ethyl tetradec-9-enoate), an esterase...

CE - Biochemie

  • 2009 - 2013
    • •
  • 4 062 tis. Kč
    • •
  • 4 062 tis. Kč
    • •
  • GA ČR
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