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957 (0,093s) •

Project

Deciphering the molecular interactions involved in the pathogenesis of European Lyme disease spirochete (7AMB17AT010)

1) Identify host extracellular matrix components, which B. afzelii binds to in order to initiate infection and colonize tissues. 2) Identify outer surface proteins of B. afzelii, which the spirochete uses to bind the extracellu...

EE - Mikrobiologie, virologie

  • 2017 - 2018
    • •
  • 118 tis. Kč
    • •
  • 118 tis. Kč
    • •
  • MŠMT
Project

Changes of the satellite glial cells and their extracellular matrix after axotomy - conditions for the sympathetic sprouts in the spinal ganglia? (GA309/03/1199)

and their extracellular matrix stimulating a growth of sympathetic sprouts into the spinalganglia in the satellite cells and their extracellular matrix content following total or partial, TGF?, p75 receptor, cGMP)...

FH - Neurologie, neurochirurgie, neurovědy

  • 2003 - 2005
    • •
  • 2 400 tis. Kč
    • •
  • 2 400 tis. Kč
    • •
  • GA ČR
Project

Membráne properties of astrocytes and the role of extracellular matrix molecules during astrogliosis in the CNS (GA305/02/1528)

Morphological and electrophysiological properties of glial cells are affected by the properties of the extracellular space. The effect of extracellular matrix molecules lacking tenascin C or tenascin R, components of the

FH - Neurologie, neurochirurgie, neurovědy

  • 2002 - 2004
    • •
  • 3 472 tis. Kč
    • •
  • 2 932 tis. Kč
    • •
  • GA ČR
Project

Tumor microenvironment of head and neck carcinoma Prognostic significance of extracellular matrix produced by tumor-associated fibroblasts (NV15-28933A)

Cancer stroma significantly influences biological properties of tumors including local aggressivity and metastasation. Extracellular matrix molecules represent, in addition to cytokines/chemokines/growth factors, the main product of...

FF - ORL, oftalmologie, stomatologie

  • 2015 - 2018
    • •
  • 11 720 tis. Kč
    • •
  • 11 720 tis. Kč
    • •
  • MZ
Project

Role of the extracelullar matrix in the extracelullar space diffusion parameter changes during aging and the metabolic syndrome (GA309/09/1597)

Our previous studies showed that the degree of learning impairment with aging correlates with a decrease in extracellular space (ECS) volume and a loss of diffusion anisotropy in hippocampus that result from structural rebuilding of the tiss...

FH - Neurologie, neurochirurgie, neurovědy

  • 2009 - 2012
    • •
  • 4 972 tis. Kč
    • •
  • 4 972 tis. Kč
    • •
  • GA ČR
Project

Development of brain organoid models to study the role of cellular senescence in the pathogenesis of glioblastoma (GA24-11357S)

to develop brain organoid models using decellularized brain extracellular matrix the production of pathogenic components of extracellular matrix and matrix remodeling enzymes......

Oncology

  • 2024 - 2026
    • •
  • 12 422 tis. Kč
    • •
  • 11 822 tis. Kč
    • •
  • GA ČR
Project

Poster Presentation on the 1998 Forum of European Neuroscience Glial Cells and Extracellular Matrix in the Rat Spinal Cord (PG98446)

údaj již není dostupný...

FH - Neurologie, neurochirurgie, neurovědy

  • 1998 - 1998
    • •
  • 33 tis. Kč
    • •
  • 22 tis. Kč
    • •
  • MŠMT
Project

Muscle remodelling on the basis of extracellular matrix seeded with functionally characterized cells. (GA15-09161S)

For the first time, we propose a novel approach to muscle organ reconstruction based on colonization of decellularized extracellular matrix (ECM) isolated from the skeletal muscle with muscle-derived cells. Simultaneously, the physi...

ED - Fyziologie

  • 2015 - 2019
    • •
  • 5 955 tis. Kč
    • •
  • 5 955 tis. Kč
    • •
  • GA ČR
Project

Properties of the extracellular space of the epileptic neocortex - significance for the pathogenesis and diagnosis of refractory epilepsy (NS9915)

By means of immunohistochemistry, the iontophoretic method in vitro as well as diffusion-weighted MRI measurements in vivo, we shall study the changes in composition and the diffusion parameters of the extracellular space in cortical dysplas...

FH - Neurologie, neurochirurgie, neurovědy

  • 2008 - 2011
    • •
  • 4 926 tis. Kč
    • •
  • 4 926 tis. Kč
    • •
  • MZ
Project

The role of brain link proteins for formation and maintenance of perineuronal nets (GA13-11867S)

Perineuronal nets (PNNs) are pericellular sheets of condensed extracellular matrix (ECM) that enwrap the cell bodies and dendrites of neurons in the adult CNS matrix and the stabilty of the ECM. Highly probably, Bral2, whic...

FH - Neurologie, neurochirurgie, neurovědy

  • 2013 - 2017
    • •
  • 4 449 tis. Kč
    • •
  • 4 449 tis. Kč
    • •
  • GA ČR
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