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1 255 (0,07s) •

Project

Clinical and molecular genetic characteristics of patients with familial hypercholesterolemia in Czech Republic (NT14186)

Detailed characterization of patients with monogenic familial hypercholesterolemia including genetic, laboratory and clinical measures focusing on identification of predictors of cardiovascular risk.A......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2013 - 2015
    • •
  • 3 323 tis. Kč
    • •
  • 3 323 tis. Kč
    • •
  • MZ
Project

Liver transplantation for hypercholesterolemia in experiment (ND4869)

Individuals with familial hypercholesterolemia will not live to be 20 years because of complications of atherosclerosis. The only successful therapeutic option is liver transplantation. The project analyzes the effect of orthotopic ...

FJ - Chirurgie včetně transplantologie

  • 1998 - 1999
    • •
  • 1 623 tis. Kč
    • •
  • 1 295 tis. Kč
    • •
  • MZ
Project

The relationship of soluble endoglin and hypercholesterolemia in patients with type 2 diabetes mellitus and the impact of therapeutical intervention. (NV17-31754A)

(90 with type 2 DM and 14 with Familial hypercholesterolemia). We aim to elucidate pathological conditions related to hypercholesterolemia, diabetes mellitus (DM, endothelial dysfunction in homozygous and heterozygous pati...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2017 - 2020
    • •
  • 8 915 tis. Kč
    • •
  • 8 915 tis. Kč
    • •
  • MZ
Project

Molecular mechanisms of familial hypercholesterolemia (NV16-29084A)

Familial hypercholesterolemia (FH) is an autosomal dominant disease with frequency of 1/200-500, associated with mutations in the LDLR, APOB, or PCSK9 genes. The aim of the project is application of techniques for functional analysi...

EB - Genetika a molekulární biologie

  • 2016 - 2019
    • •
  • 7 332 tis. Kč
    • •
  • 7 332 tis. Kč
    • •
  • MZ
Project

Phenotype Genotype Correlation in Children and Adolescents with Heterozygous Familial Hypercholesterolemia (NA7452)

The correlation of genotype with phenotype in children suffering from fam.hypercholesterolemia will be studied. Genotype is characterized by lo most common gene mutations for apoB, LDL-cholest.receptors, apoE allels. Phenotype will be characterized b...

FG - Pediatrie

  • 2003 - 2005
    • •
  • 5 429 tis. Kč
    • •
  • 4 635 tis. Kč
    • •
  • MZ
Project

Mechanisms of the effect of genetic variants of LDL receptor and the role of genetic variants of lipoprotein(a) in the development of hypercholesterolemia in FH patients (NU20-02-00261)

The frequency of familial hypercholesterolemia (FH) in most populations is about 1/200, and so it is possible to predict that about 50,000 people could be affected by FH in the Czech Republic. The project solution can be divided int...

Biochemistry and molecular biology

  • 2020 - 2023
    • •
  • 12 741 tis. Kč
    • •
  • 12 741 tis. Kč
    • •
  • MZ
Project

LDL gene score in the diagnosis of primary hypercholesterolemias and cardiovascular risk assessment (NV15-28277A)

Familial hypercholesterolemia (FH) is autosomal dominant disorder caused mostly by mutations in the LDL-receptor gene or the the gene encoding for apolipoprotein B. Prognosis of the affected patients differs even among carriers of t...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2015 - 2018
    • •
  • 9 760 tis. Kč
    • •
  • 9 760 tis. Kč
    • •
  • MZ
Project

The role of dietary cholesterol in regulation of gene expression in the model of dietary induced hypercholesterolemia (NR9401)

The expression of genes that respond to dietary cholesterol and those responsible for development of hypercholesterolemia will be studied in experimental model of diet induced hypercholesterolemia - Prague hereditary hypercholestero...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2009
    • •
  • 4 928 tis. Kč
    • •
  • 4 857 tis. Kč
    • •
  • MZ
Project

Development of diagnostics and treatment of serious heart and vascular diseases using genomic and proteomic approaches (2B08060)

The aim of the project is to introduce novel molecular-genetic, genomic and proteomic approaches in diagnostics of serious heart and vascular diseases.......

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2008 - 2011
    • •
  • 27 550 tis. Kč
    • •
  • 24 678 tis. Kč
    • •
  • MŠMT
Project

Genetic plymorphisms, MicroRNAs and bioindicators of activity interrelations in the diagnostics and therapy of severe familial hypercholesterolemia (NV17-28882A)

polymorphisms related to atherosclerosis in patients with severe hypercholesterolemia under...

EB - Genetika a molekulární biologie

  • 2017 - 2020
    • •
  • 15 886 tis. Kč
    • •
  • 15 886 tis. Kč
    • •
  • MZ
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