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Projects

10 projects (0,212s)

Project

Dermis replacement in burns and other extensive skin defects (IZ3725)

FP - Ostatní lékařské obory

  • 1996 - 1998
  • 1 107 tis. Kč
  • 1 107 tis. Kč
  • MZ
Project

Development of definitive skin implant based on collagen lattice and autologous cells for the treatment of burn wounds in the animal model. (IZ3093)

FJ - Chirurgie včetně transplantologie

  • 1995 - 1997
  • 380 tis. Kč
  • 380 tis. Kč
  • MZ
Project

Recombined artificial skin for treatment of burns (ND5699)

The projekt aims to optimize the authorś original "artificial skin" technique based on a collagen -HA composite and polyurethan membrane, to upgrade it through seeding with fibroblasts and to conduct a randomized clinical study for its evaluation.......

FJ - Chirurgie včetně transplantologie

  • 1999 - 2001
  • 1 874 tis. Kč
  • 1 834 tis. Kč
  • MZ
Project

Molecular mechanisms of congenital disorders of glycosylation (NV16-31932A)

Congenital Disorders of Glycosylation (CDG) represents a large group of severe inherited metabolic diseases that are caused by impaired biosynthesis of glycoproteins and glycolipids.The complexity of glycosylation pathways determines the occurrence o...

CE - Biochemie

  • 2016 - 2020
  • 11 463 tis. Kč
  • 11 435 tis. Kč
  • MZ
Project

Markers of mitochondrial dysfunction in presymptomatic and early stages of Huntington‘s disease (NU20-04-00136)

Huntington's disease (HD) is an autosomal dominant hereditary neurodegenerative disorder, manifested mainly by progressive movement disorders, behavioral changes and cognitive impairment. There is no treatment to stop or even cure the disease. The c...

Neurosciences (including psychophysiology)

  • 2020 - 2024
  • 11 692 tis. Kč
  • 11 641 tis. Kč
  • MZ
Project

Treatment of diabetic wounds using nanofibrous dressings releasing platelet lysate components. (NV18-01-00332)

Treatment of diabetic wounds is problematic, long-lasting, expensive and restrictive for patients. Platelets are physiologically present in the process of healing of acute wounds, where they secret growth and angiogenic factors, cytokines, chemokines...

Endocrinology and metabolism (including diabetes, hormones)

  • 2018 - 2022
  • 12 686 tis. Kč
  • 12 620 tis. Kč
  • MZ
Project

Effect of metabolic reprogramming of cancer associated fibroblasts on the prognosis of head and neck cancer patients (NU21-03-00223)

Tumor microenvironment consists of various cell populations, for example cancer associated fibroblasts. In many solid tumors, so-called metabolic symbiosis occurs, during which fibroblast-produced lactate serves as a source of carbon for cancer cells...

Cell biology

  • 2021 - 2024
  • 10 061 tis. Kč
  • 10 061 tis. Kč
  • MZ
Project

Exosomal RNA produced by cancer-associated fibroblasts as a relevant marker in head and neck cancer prognosis (NU20J-08-00018)

Head and neck squamous cell carcinomas (HNSCC) are the fifth most common solid cancer. Unfortunately, no significant improvement has been achieved in HNSCC patient survival due to unpredictable therapy response and therapy resistance which may be sig...

Oncology

  • 2020 - 2023
  • 12 657 tis. Kč
  • 12 657 tis. Kč
  • MZ
Project

The proteome of extracellular vesicles – the unexplored area of intercellular communication in the tumor microenvironment of head and neck cancer (NU22-03-00202)

Head and neck squamous cell carcinoma (HNSCC) is common and severe solid cancer. Cancer-associated fibroblasts (CAFs) can promote HNSCC progression and therapy resistance by secreting factors contained in exosomes. Exosomes are released from CAFs and...

Otorhinolaryngology

  • 2022 - 2025
  • 10 468 tis. Kč
  • 10 468 tis. Kč
  • MZ
Project

Cell-mediated multilayered 4th generation biomimetic scaffold for single-step total skin substitute from laboratory to clinical application (NU22-08-00454)

Skin tissue engineering exploiting non-toxic resorbable biomaterials has been a major success in the last few decades. In the skin, one can find various cell populations that are arranged in a unique three-dimensional matrix, creating a complex of mi...

Transplantation

  • 2022 - 2025
  • 14 308 tis. Kč
  • 14 308 tis. Kč
  • MZ
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