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102 (0,151s) •

Project

Hepatic stellate cells scintigraphy as a marker of early liver fibrosis (NR7833)

Isotope-labeled compounds will be synthetized for scintigraphical detection of hepatic stellate cells transformation in the early stages of liver fibrosis. Compound feasibility will be tested on liver fibrosis animal models.......

FE - Ostatní obory vnitřního lékařství

  • 2004 - 2006
    • •
  • 1 895 tis. Kč
    • •
  • 1 827 tis. Kč
    • •
  • MZ
Project

The effects of deport steroids in preventing the occurrence of postoperative fibrosis. (NF6559)

Control of new possibilities in the prevention of postoperative epidural fibrosis with the help of the application of materials preventing bleeding in the epidural area and basic depot steroids. Regular controls using a double blind study ad...

FH - Neurologie, neurochirurgie, neurovědy

  • 2001 - 2003
    • •
  • 532 tis. Kč
    • •
  • 532 tis. Kč
    • •
  • MZ
Project

Improvement of care for patients with cystic fibrosis by early and efficient diagnosis via two-tier neonatal screening programme (1A8236)

The aim is to assess the efectivity of newborn screening for cystic fibrosis in the condition of Czech Republic....

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
    • •
  • 6 193 tis. Kč
    • •
  • 6 182 tis. Kč
    • •
  • MZ
Project

Analysis of Extracellular Niche in Mouse Models of Liver Fibrosis (GA18-02699S)

Liver fibrosis is excessive scarring process resulting from chronic insults pathology with high mortality. The major hallmark of liver fibrosis is deposition the development and resolution of two different types of liver fibrosi...

Cell biology

  • 2018 - 2022
    • •
  • 8 694 tis. Kč
    • •
  • 7 813 tis. Kč
    • •
  • GA ČR
Project

Impact of direct endoglin modulation on the development of major complications of metabolic syndrome atherogenesis and non-alcoholic steatohepatitis (GA22-14961S)

dysfunction, atherogenesis, liver fibrosis, and non-alcoholic steatohepatitis (NASH or alleviate atherogenesis, liver fibrosis, and NASH. We will focus on changes in Eng of Eng on fibrosis will be studied in a mouse model ...

Pharmacology and pharmacy

  • 2022 - 2024
    • •
  • 8 954 tis. Kč
    • •
  • 8 954 tis. Kč
    • •
  • GA ČR
Project

Identification of markers of interstitial fibrosis in asymptomatic hydronephrosis in infants (NK6605)

The aim of the proposed project is to to study the ACE serum and urinary activity and urinary excretion of TGF beta 1 in relationship to the degree of interstitial fibrosis in infants with asymptomatic hydronephrosis......

FG - Pediatrie

  • 2001 - 2003
    • •
  • 1 335 tis. Kč
    • •
  • 1 289 tis. Kč
    • •
  • MZ
Project

Genetic determinants of interstitial fibrosis and coronary microvascular remodelation (LH11049)

We will use histomorphometric analyses to determine the presence and extent of coronary microvascular remodeling and myocardial fibrosis in the BXH/HXB recombinant inbred strains derived from the spontaneously hypertensive rats (SHR) and Bro...

EB - Genetika a molekulární biologie

  • 2011 - 2014
    • •
  • 3 564 tis. Kč
    • •
  • 3 564 tis. Kč
    • •
  • MŠMT
Project

Immune system in children with cystic fibrosis III. - factors modifying the course of the disease (NI7486)

Project...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2003 - 2005
    • •
  • 1 808 tis. Kč
    • •
  • 1 786 tis. Kč
    • •
  • MZ
Project

Roles of the rhomboid intramembrane protease RHBDL2 in lung epithelial homeostasis and pathology of idiopathic pulmonary fibrosis (GA21-24456S)

in the rhomboid intramembrane protease RHBDL2 are markedly protected from pulmonary fibrosis in epithelial cells, and hypothesise that this underlies its influence on lung fibrosis. Now underlying the role of RHBDL2 in fibrosis...

Cell biology

  • 2021 - 2023
    • •
  • 9 840 tis. Kč
    • •
  • 9 345 tis. Kč
    • •
  • GA ČR
Project

Risk factors leading to diabetes mellitus in patients with cystic fibrosis in the Czech republic (NB6461)

Impaired glucose tolerance and diabetes mellitus in patients with cystic fibrosis. Relation of clinical parameters, CFTR genotype and markers of insulitis (HLA class II., antibodies IAA, IA-2 GAD). Determination of the risk factors, optimali...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2001 - 2003
    • •
  • 3 105 tis. Kč
    • •
  • 3 043 tis. Kč
    • •
  • MZ
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