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1 274 (0,367s) •

Project

Screening of mutations in the non-duplicated region of the PKD1 gene from families with autosomal dominant polycystic kidney disease (NE7633)

Analysis of mutations in non-duplicated region of the PKD1 gene in selected families with ADPKD by screening methods (SSCP,HA,DGGE) and following sequencing of positive fragments.......

EB - Genetika a molekulární biologie

  • 2003 - 2005
    • •
  • 3 439 tis. Kč
    • •
  • 3 364 tis. Kč
    • •
  • MZ
Project

Screening of mutations in the duplicated region of the PKD1 gene from families with autosomal dominant polycystic kidney disease (NR9427)

Analysis of mutations in duplicated region of the PKD1 gene in selected families with ADPKD by LR-PCR , screening methods (SSCP,HA,DGGE) and following sequencing of positive fragments.......

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 4 789 tis. Kč
    • •
  • 4 669 tis. Kč
    • •
  • MZ
Project

Screening of mutations in the PKD2 gene from families with autosomal dominant polycystic kidney disease. (NE5996)

Analysis of mutations in PKD2 gene in selected families with ADPKD by screening methods (SSCP,HA,DGGE) and following sequenation of positive fragments. Analysis of mutations in PKD2 gene is the only temporary available method in dif...

FE - Ostatní obory vnitřního lékařství

  • 2000 - 2002
    • •
  • 3 422 tis. Kč
    • •
  • 3 420 tis. Kč
    • •
  • MZ
Project

Mutational analysis of BRCA1 and BRCA2 genes in hereditary forms of breast and ovarian cancer. Clinical application in the South Moravian region. (NC5561)

Molecular-genetic testing of mutations in BRCA1 and BRCA2 genes by some of the screening methods (SSCP,HA,CDCE,PTT) Sequencing analysis of PCR fragments with detected mutations by screening methods.......

FD - Onkologie a hematologie

  • 1999 - 2001
    • •
  • 3 675 tis. Kč
    • •
  • 3 675 tis. Kč
    • •
  • MZ
Project

System for searching for new biologically active compounds. Foccused combinatorial libraries. (FT-TA5/136)

IMG AS CR owns a unique technology for high-throughput screening for biological activity. RE&D VUFB company is experienced in medicinal chemistry and builds the technology for parallel synthesis combinatorial chemistry. In this co-operation ...

CC - Organická chemie

  • 2008 - 2010
    • •
  • 11 224 tis. Kč
    • •
  • 7 127 tis. Kč
    • •
  • MPO
Project

Improve the output of primary screening of biologically active compounds using computational models (LTARF18013)

biological screening taking into account molecular activity, side activity and metabolic-throughput screening based on data set visualization using advanced dimensionality of fragment replacements of a given seed compound(...

Organic chemistry

  • 2018 - 2020
    • •
  • 7 803 tis. Kč
    • •
  • 7 803 tis. Kč
    • •
  • MŠMT
Project

Design, synthesis, screening and functional study of peptides with high affinity to heavy metals;their presentation on bacterial surface (GA203/98/0650)

In this proposal we describe the synthesis, testing and characterization of peptide fragments that show improved binding characteristics for specific heavy metals and screening of peptide libraries. Parallel approach will be based o...

CE - Biochemie

  • 1998 - 2000
    • •
  • 1 996 tis. Kč
    • •
  • 1 849 tis. Kč
    • •
  • GA ČR
Project

Development of actin polymerization inhibitors as potential migrastatics (GM23-05336M)

, that directly inhibit actin polymerization, will be developed based on virtual screening and fragment growing. Inhibitors of ARPC1, a subunit of the Arp2/3 complex and actin and their effect on cancer cell invasion will be studied...

Organic chemistry

  • 2023 - 2027
    • •
  • 23 096 tis. Kč
    • •
  • 23 096 tis. Kč
    • •
  • GA ČR
Project

Lactone-based natural products useful leads in the development of new antifungals and antineoplastics (GA203/07/1302)

be of higher importance in drug discovery and development than random screening of huge ongoingresearch on small bioactive natural products containing an unsaturated lactone fragment, such as carbonylative lactonization, will be fu...

CC - Organická chemie

  • 2007 - 2009
    • •
  • 2 421 tis. Kč
    • •
  • 2 421 tis. Kč
    • •
  • GA ČR
Project

Natural Lactones and Lactams Towards Diverse Biological Activities through Purposeful Synthetic Manipulations (GA15-07332S)

and screening of small libraries of purposefully designed analogues of selected natural products incorporating a lactone or lactam structural fragment. Specifically, several screening. Secondly, in order to increase effici...

CC - Organická chemie

  • 2015 - 2017
    • •
  • 4 908 tis. Kč
    • •
  • 4 908 tis. Kč
    • •
  • GA ČR
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