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5 (0,184s)

Project

The role of gangliosides in the development of neurodegenerative amyloidogenic diseases Molecular insights by advanced fluorescence microscopy (GA17-03160S)

membranes. Although the metabolism of the lipid class “ganglioside” is linked to AD of ganglioside GM1 prevent in-membrane oligomerization of Ab. Based on our findings we propose to answer several questions: Do other gangliosid...

BO - Biofyzika

  • 2017 - 2019
  • 6 342 tis. Kč
  • 5 661 tis. Kč
  • GA ČR
Project

Mapping galectin-ganglioside networks on complex model membrane systems (GA25-15346S)

galectin-3 with ganglioside GM1. Bridging critical knowledge gaps, the project strives...

Physical chemistry

  • 2025 - 2027
  • 9 219 tis. Kč
  • 8 841 tis. Kč
  • GA ČR
Project

The role of heme catabolic pathway in in the pathogenesis of cholestasis (NR9366)

The proposed grant project is focused on the role of HO and its metabolic products, bilirubin and carbon monoxide (CO) on the maintenance of bile flow and sinusoidal tone in the liver tissue, in particular its role in the pathogenesis of cholestasis....

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2010
  • 4 406 tis. Kč
  • 4 406 tis. Kč
  • MZ
Project

Phenotype-genotype relations in lysosomal storage diseases related to beta-galactosidase deficiency (MEB060904)

-degradation studies with the natural substrate [3H]GM1-ganglioside will be done...

CE - Biochemie

  • 2009 - 2010
  • 134 tis. Kč
  • 134 tis. Kč
  • MŠMT
Project

Development of methods for comprehensive monitoring of metabolite changes in central nervous system disorders (GA22-13967S)

Central nervous system (CNS) disorders represent a serious health, social, and economic problem for the population due to the annual increase in cases. Metabolic profiling of the healthy and disease CNS in preclinical models or human samples may prov...

Analytical chemistry

  • 2022 - 2024
  • 6 012 tis. Kč
  • 6 012 tis. Kč
  • GA ČR
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