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3 127 (1,386s) •

Project

Laboratory of gene expression (VS96129)

Gene expression with a special emphasis on a structure-functional organization of transcription and splicing apparatus....

EA - Morfologické obory a cytologie

  • 1996 - 2000
    • •
  • 39 208 tis. Kč
    • •
  • 30 985 tis. Kč
    • •
  • MŠMT
Project

Artificial epigenetics Development of a eukaryotic bioorthogonal transcription system for gene expression manipulation in the cell. (GA17-03419S)

of gene expression. Artificial DNA modifications possess immense potential with respect to modulate the way how RNA polymerase (the key enzyme of transcription) and/or transcription factors interact with DNA. We propose to...

EB - Genetika a molekulární biologie

  • 2017 - 2019
    • •
  • 9 537 tis. Kč
    • •
  • 9 072 tis. Kč
    • •
  • GA ČR
Project

Expression of lincomycin biosynthetic gene cluster and its regulation (GA204/05/0616)

library, gene inactivation, localization of transcription starts (primer extensionThe project aims in finding the organization of transcriptional units within the lincomycin biosynthetic cluster and identifying transcr...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 2 466 tis. Kč
    • •
  • 2 466 tis. Kč
    • •
  • GA ČR
Project

Integrative analysis of the role of bZIP transcription factors in pollen maturation (GA522/09/0858)

. Different expression profiles of genes encoding male gametophytic transcription factors suggest the existence of specific mechanisms of regulation of late pollen gene genes and biological pathway(s) regulated by ...

EF - Botanika

  • 2009 - 2012
    • •
  • 5 057 tis. Kč
    • •
  • 5 057 tis. Kč
    • •
  • GA ČR
Project

The Ribosomal Gene Transcription in Transformed Blood Cells Expression and Interaction of the Regulatory Proteins and their Posttranslational Modifications. Th (IZ4073)

Expression and function studies of transcription factors invelved in ribozomal gene transcription performed on a set of leukemic cell lines,in vitro stimulated lamphocytes and blood cells of leukemic patients. Characterizat...

FD - Onkologie a hematologie

  • 1997 - 1999
    • •
  • 5 401 tis. Kč
    • •
  • 3 608 tis. Kč
    • •
  • MZ
Project

The role of Cdk12 and C-terminal domain of RNA polymerase II in transcription-coupled genome instability (GA14-09979S)

RNA polymerase II (RNAPII) directs transcription of protein-coding genes regulates transcription cycle and other cellular functions. Our study implicated the CTD to have a role in transcription-coupled genome insta...

EB - Genetika a molekulární biologie

  • 2014 - 2016
    • •
  • 7 155 tis. Kč
    • •
  • 7 155 tis. Kč
    • •
  • GA ČR
Project

Topography of nuclear architecture associated with the RNA synthesis,processing and transport. (GV304/96/K002)

that the distribution of gene transcripts depends on the position of the gene within the cell nucleus as well as on the number of gene copies (unique, tandem repeated), lenght of the gene, level of tr...

EB - Genetika a molekulární biologie

  • 1996 - 1998
    • •
  • 4 209 tis. Kč
    • •
  • 4 209 tis. Kč
    • •
  • GA ČR
Project

Transcription regulation of the HOX genes in normal and leukemic hematopoiesis (GAP304/12/2214)

Homeobox (HOX) genes are conserved transcription factors involved data and study transcription regulation of HOX genes in normal hematopoietic cells is DNA methylation, as we have discovered negative correlation of...

FD - Onkologie a hematologie

  • 2012 - 2018
    • •
  • 13 517 tis. Kč
    • •
  • 13 517 tis. Kč
    • •
  • GA ČR
Project

Transcriptional pulsing and the stem cell phenotype (GAP305/12/1246)

Live cell imaging has recently revealed that transcription is a discontinuous process at the single cell level, with individual genes oscillating between periods of activity and inactivity. Here we propose that such transcriptio...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 7 544 tis. Kč
    • •
  • 7 544 tis. Kč
    • •
  • GA ČR
Project

Functions of nuclear myosin in gene expression (GA204/07/1592)

transcription, Aim 2: Identification of NMI functions in transcriptionally inactive nuclear of the physiological role of NMI in DNA transcription, gene expression, and cell metabolism). Recently, we have shown tha...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 5 701 tis. Kč
    • •
  • 5 701 tis. Kč
    • •
  • GA ČR
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