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5 925 (0,17s) •

Project

Synthetic biodegradable polymeric systems for targeted gene delivery (KJB400500803)

The project focuses on the synthesis of new biodegradable gene delivery vectors designed for efficient gene therapy. These delivery vectors should protect the gene (DNA) from degradation in blood circulation and release it ...

CD - Makromolekulární chemie

  • 2008 - 2009
    • •
  • 638 tis. Kč
    • •
  • 638 tis. Kč
    • •
  • AV ČR
Project

Possibility of targetted genes using in flax and linseed transformation (1P05ME800)

methods of detection of transgenes and evidence of succesful transformation...

GE - Šlechtění rostlin

  • 2005 - 2008
    • •
  • 1 064 tis. Kč
    • •
  • 1 064 tis. Kč
    • •
  • MŠMT
Project

Functional Genomics of Dioecious Plants (LH14002)

and genes with sex-specific expression. An efficient method enabling targeted of genes in various organisms. However, their functional validation remains rather and/or targeted mutagenesis are not feasible. In mod...

EB - Genetika a molekulární biologie

  • 2014 - 2016
    • •
  • 4 557 tis. Kč
    • •
  • 1 780 tis. Kč
    • •
  • MŠMT
Project

Targeted mutagenesis in silkworm (GAP305/10/2406)

of this project is to explore the possible application of gene targeting by zinc finger based mutagenesis in Bombyx mori. This method is based on creating gene-specific double stranded. In our preliminary experiments we ch...

EB - Genetika a molekulární biologie

  • 2010 - 2014
    • •
  • 6 804 tis. Kč
    • •
  • 6 804 tis. Kč
    • •
  • GA ČR
Project

Targets and consequences of activation-induced cytidine deaminase-mediated mutagenesis in tumours (GN24-11338I)

genes of activated B cells and is required for the production of high-affinity antibodies. However, AID also causes mutations in non-immunoglobulin genes, contributing to the development of tumours. Histone genes are frequ...

Cell biology

  • 2024 - 2027
    • •
  • 6 323 tis. Kč
    • •
  • 6 323 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms of the tumor suppressor function of the HIC1 gene (GAP305/12/2347)

. To observe a possible crosstalk with the Wnt pathway the Hic1 gene will be inactivated in the target tissues together with the Apc gene encoding the Wnt signaling inhibitor. The Hic1 target genes will be...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 9 953 tis. Kč
    • •
  • 9 953 tis. Kč
    • •
  • GA ČR
Project

The role of Meis homeobox genes in retina development (GA18-20759S)

genetics via the use of transgenics and conditional gene targeting with the genome-wide studies of Meis target genes. Dissection of the molecular networking and its genetic genes play during development. ...

Developmental biology

  • 2018 - 2022
    • •
  • 7 743 tis. Kč
    • •
  • 7 155 tis. Kč
    • •
  • GA ČR
Project

Tick microRNAs as modulators of vertebrate host physiology (LUABA22020)

Aim 1: Localization and quantification of miRNAs in Ixodes ricinus ticks Aim 2: Cloning of tick miRNA targets and study of the effect of miRNA on mammalian cells Aim 3: Transcriptomic analysis of host gene modulation upon tick m...

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 1 199 tis. Kč
    • •
  • 1 199 tis. Kč
    • •
  • MŠMT
Project

Transcription factor MITF ? critical regulator of proliferation and viability of melanoma cells and a target of molecular anticancer therapy. (NT11229)

of the role of MITF in melanoma progression and may be a route to targeted gene therapy genes among which are differentiation markers and genes maintaining the viability targets. Blocking of the MITF expr...

FD - Onkologie a hematologie

  • 2010 - 2012
    • •
  • 4 638 tis. Kč
    • •
  • 4 638 tis. Kč
    • •
  • MZ
Project

Polyomavirus Pseudocapsids as Vectors Applications for Genetic and Immunological Therapeutic Purposes of Modified VP1 Pseudocapsids (OK 372)

utilisation of the system for gene therapy purposes it is necessary a) to understand themechanisms of individual steps of the transport of gene information from cell membrane to the nuclus, b) to manipulate original viral structure...

EE - Mikrobiologie, virologie

  • 1998 - 2001
    • •
  • 2 773 tis. Kč
    • •
  • 1 853 tis. Kč
    • •
  • MŠMT
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