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2 089 (0,217s) •

Project

The application of CRISPR-Cas9 for the creation of multiple mutants in the genes coding for the nascent polypeptide associated complex (LTC20050)

of this project is to employ modern genome editing techniques to acquire the multiple mutants the β-subunit). These genome-edited plants will be characterized in more detail-associated complex by the modern ge...

Plant sciences, botany

  • 2020 - 2023
    • •
  • 4 863 tis. Kč
    • •
  • 4 863 tis. Kč
    • •
  • MŠMT
Project

Genome editing in plants - IEB CAS contribution (LTC20066)

The main goal of the project is to extend the possibilities of genome editing in highly recalcitrant Cannabis sp. To achieve this goal, we will use different methodological approaches of gene transfer in combination with regeneratio...

Biochemistry and molecular biology

  • 2020 - 2023
    • •
  • 4 198 tis. Kč
    • •
  • 4 198 tis. Kč
    • •
  • MŠMT
Project

Genome editing to treat Stargardts disease – Generation and phenotyping of a porcine model and development of a treatment approach (GC19-09628J)

a positive effect of genome editing. disease type 1, caused by mutation in ABCA4 gene. The proposed ABCA4 gene editing...

Health-related biotechnology

  • 2019 - 2022
    • •
  • 12 272 tis. Kč
    • •
  • 12 002 tis. Kč
    • •
  • GA ČR
Project

CRISPR-Cas barley genome editing prospective tool for modern breeding (GA17-07805S)

Drought is a major environmental stress factor, which has begun to negatively affect yield of cereal crops. Method of stable genetic barley transformation will be used for novel, very efficient and easy-to-design genome editing by C...

GE - Šlechtění rostlin

  • 2017 - 2021
    • •
  • 7 016 tis. Kč
    • •
  • 6 969 tis. Kč
    • •
  • GA ČR
Project

Genomic approaches towards the improvement of pod shatter resistance in Brassica napus (8JCH1031)

and genome editing (PRC-CZ) • analysis of Czech genetic resources of rapeseed, evaluation pyramiding technology using MAS approach and use of CRISPR / Cas9 for genome editing and research of rape genome /...

GM technology (crops and livestock), livestock cloning, marker assisted selection, diagnostics (DNA chips and biosensing devices for the early/accurate detection of diseases) biomass feedstock production technologies, biopharming

  • 2019 - 2021
    • •
  • 296 tis. Kč
    • •
  • 296 tis. Kč
    • •
  • MŠMT
Project

Solving missing heritability in inherited retinal diseases using integrated omics and gene editing in human cellular and animal models (8F20004)

i) to dissect the regulation of inherited retinal diseases (IRD) genes in human retina to improve functional genome annotation. ii) to revisit clinical diagnoses and generate relevant cellular models derived from unsolved monoallelic cases ...

Other medical science

  • 2020 - 2022
    • •
  • 6 162 tis. Kč
    • •
  • 3 444 tis. Kč
    • •
  • MŠMT
Project

Emergence of pathogenicity for vertebrates insight from ancestral bodonids and insect trypanosomatids (GA14-23986S)

Main aim of this project is to find out which changes in the genomes of monoxenous (= single-host) insect trypanosomatids triggered their transformation, assemble and annotate several genomes of flagellates representing the diversit...

EB - Genetika a molekulární biologie

  • 2014 - 2016
    • •
  • 3 590 tis. Kč
    • •
  • 3 590 tis. Kč
    • •
  • GA ČR
Project

Exploring non-canonical ORFs with functions in DNA damage repair (EH22_010/0008995)

of the human genome 20 years ago. However, recent technological advances have revealed that our genome's protein-coding capacity is greater than previously thought, giving components of the dark proteome with specific functions in m...

Genetics and heredity (medical genetics to be 3)

  • 2025 - 2028
    • •
  • 3 904 tis. Kč
    • •
  • 988 tis. Kč
    • •
  • MŠMT
Project

Building Barbara McClintock’s legacy Evolution of ribosomal DNA in chromosomal context (GA25-16796S)

painting and genome editing by CRISPR/Cas technology. Specifically, we will investigateRibosomal RNA genes (rDNAs) have long fascinated researchers, representing a captivating enigma within molecular biology. Despite relatively sma...

Genetics and heredity (medical genetics to be 3)

  • 2025 - 2027
    • •
  • 15 123 tis. Kč
    • •
  • 14 802 tis. Kč
    • •
  • GA ČR
Project

Chemical modulation of Ku activity and its use in genome editing. (GA19-21961S)

Genome integrity is governed by multiple mechanisms among which the pathways dealing with broken DNA ends are the most complex. Due to its strong DNA-end binding activity, Ku is one of the key molecules involved in metabolism of DNA breaks f...

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 8 922 tis. Kč
    • •
  • 8 430 tis. Kč
    • •
  • GA ČR
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