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1 430 (0,843s) •

Project

The study of genotoxicity of sarin, soman and HI-6 oxime, and their influence on the effect of mutagenic and carcinogenic compounds (MO66021299108)

The risk assessment of the carcinogenicity of low doses of nerve paralytic agents and HI-6....

EB - Genetika a molekulární biologie

  • 1999 - 2001
    • •
  • 487 tis. Kč
    • •
  • 487 tis. Kč
    • •
  • MO
Project

Genotoxic synergy between non-mutagenic pesticides and environmental mutagens (GA521/97/0128)

The capability of plants to bioconcentrate environmental agents and to activate is (i) to conduct a genotoxic investigation on the discovered synergistic mutagenic) to determine if the synergistic genotoxic response is expr...

EB - Genetika a molekulární biologie

  • 1997 - 1999
    • •
  • 3 912 tis. Kč
    • •
  • 1 540 tis. Kč
    • •
  • GA ČR
Project

Induced DNA damage, mutagenicity, homologous recombination and apoptosis as endpoints for monitoring effects of pollutants in tobacco and potato (GA521/05/0500)

We propose to study the genotoxic effects of 2 types of pollutants: 1 pollutants. We intend to study the genotoxicity of PCB and its metabolic products under contaminated soil in North Bohemia. We will monitor the total genotoxi...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 2 536 tis. Kč
    • •
  • 2 536 tis. Kč
    • •
  • GA ČR
Project

The application of modern molecular genetic methods for the determination of genotoxic changes in at-risk populations (NV15-33968A)

of the exposure to genotoxic agents (GA) and their expected consequences; however...

FM - Hygiena

  • 2015 - 2018
    • •
  • 13 401 tis. Kč
    • •
  • 11 213 tis. Kč
    • •
  • MZ
Project

Senescence cells elimination in minimal residual tumour disease therapy (NT14461)

genotoxic and epigenetic agents combined with immunotherapy, using preclinical murineInteractions of tumour cells with the immune system are influenced by chemotherapy with genotoxic or tumour cell senescence-inducing effe...

FD - Onkologie a hematologie

  • 2013 - 2015
    • •
  • 7 094 tis. Kč
    • •
  • 7 094 tis. Kč
    • •
  • MZ
Project

Genotoxic and non-genotoxic mechanisms involved in carcinogenicity of complex mixtures of air pollutants toxicogenomic approach (GAP503/11/0142)

containing genotoxic as well as non-genotoxic carcinogens. Multistage process of chemical carcinogenesis relates both genotoxic as well as non-genotoxic mechanisms. The major aim air complex mixture components and...

DN - Vliv životního prostředí na zdraví

  • 2011 - 2015
    • •
  • 11 588 tis. Kč
    • •
  • 11 588 tis. Kč
    • •
  • GA ČR
Project

Research and development of a new type of electrochemical biosensor for the detection of nucleotide sequences in DNA and of genotoxic agents in the environment. (1H-PK/42)

At present there is an increasing interest in devices (sensors, chips, etc.) suitable for rapid detection of a large number of nucleotide sequences in DNA and RNA, based on optical methods. It is the intention of this project to complement the optica...

EI - Biotechnologie a bionika

  • 2004 - 2007
    • •
  • 14 864 tis. Kč
    • •
  • 7 403 tis. Kč
    • •
  • MPO
Project

Thermodynamics of DNA damaged by physical and chemical agents (GAP205/11/0856)

mechanisms underlying biological effects of the genotoxic agents from the viewpoint physical and chemical agents is a crucial factor controlling recognition and repair agents and to use it in the process of preven...

BO - Biofyzika

  • 2011 - 2015
    • •
  • 5 719 tis. Kč
    • •
  • 5 719 tis. Kč
    • •
  • GA ČR
Project

Interactions of wild type and mutant p53 proteins with damaged DNA and their roles in cellular response to anticancer chemotherapy (IAA500040701)

of genotoxic agents on p53-DNA binding at the level of model cell lines. binding, and (3) influence of genotoxic substances on mut p53 binding to genomic DNA......

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 4 824 tis. Kč
    • •
  • 4 824 tis. Kč
    • •
  • AV ČR
Project

Mechanisms of genotoxic effects of chemical carcinogen 1,3butadien adaptive response and individual susceptibility (GA310/01/0802)

1,3-Butadiene (BD), an important industrial and environmental xenobiotic, was shown to be genotoxic, but mechanisms of BD genotoxicity are not clear. The aim of the project would be an investigation of relationships between various ...

FM - Hygiena

  • 2001 - 2003
    • •
  • 9 744 tis. Kč
    • •
  • 4 767 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 1 430