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50 (0,117s) •

Project

The fate of immortality Understanding the mechanisms of germline-soma distinction in birds (GA25-17195S)

The early specification of the immortal germline and the development of a truly disposable soma, whose main function is to carry the germline to the next generation, the genetic and molecular mechanisms behind the germline-...

Developmental biology

  • 2025 - 2027
    • •
  • 13 363 tis. Kč
    • •
  • 13 363 tis. Kč
    • •
  • GA ČR
Project

Molecular analysis of the APC and MYH genes in families affected with familial adenomatous polyposis or multiple adenomas (NR8103)

Genetic causes of FAP, AFAP and multiple adenomas in the selected set of families with no demonstrable germline APC mutation. Analysis of invisible germline APC mutations and of germline MYH mutations. Mutation analysis usi...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 2 846 tis. Kč
    • •
  • 2 810 tis. Kč
    • •
  • MZ
Project

Germline restricted chromosome in songbirds understanding its origin, function and evolutionary significance (GA20-23794S)

In songbirds, an extra chromosome exists in the germinal cells. This so-called germline restricted chromosome (GRC) is inherited only through females and early during development is eliminated from the somatic cells being maintained only in ...

Zoology

  • 2020 - 2023
    • •
  • 9 871 tis. Kč
    • •
  • 9 871 tis. Kč
    • •
  • GA ČR
Project

Transposable elements regulation in plant germlines (GA22-00364S)

Although transposable elements (TEs) remain silenced in somatic tissues of plants, in germlines, the silencing is temporarily relaxed due to epigenetic genome reprogramming and TEs are active. Plants have developed defense mechanisms to prev...

Plant sciences, botany

  • 2022 - 2024
    • •
  • 8 391 tis. Kč
    • •
  • 8 391 tis. Kč
    • •
  • GA ČR
Project

Germline mutations of PML gene in patients with cancer (NR9092)

Mutational analysis of PML gene will be performed in patients with breast and colon cancer with suspect hereditary predisposition to cancer. Cyclin D1 and ZNF217 gene amplification analysis will be performed in breast cancer samples associated with h...

FD - Onkologie a hematologie

  • 2006 - 2008
    • •
  • 2 645 tis. Kč
    • •
  • 2 244 tis. Kč
    • •
  • MZ
Project

Germline, weakly activating JAK2 variants predisposing to myeloid malignancies cooperation with driver leukemogenic oncogene (NU21-03-00338)

Recognition of germline predispositions to myeloid malignancies is increasing. We previously described and characterized germline JAK2 R1063H mutation, weakly frequency of germline JAK2 R1063H in AML. In addition, we functi...

Hematology

  • 2021 - 2025
    • •
  • 14 557 tis. Kč
    • •
  • 14 486 tis. Kč
    • •
  • MZ
Project

Sex-specific proliferation of transposable elements in plants (GA19-15609S)

genome reprogramming in developing germlines. How different circumstances in a male and a female plant and different TE-silencing mechanisms during male and female germline either in male or female germline. We will study ...

Plant sciences, botany

  • 2019 - 2023
    • •
  • 8 306 tis. Kč
    • •
  • 8 306 tis. Kč
    • •
  • GA ČR
Project

Biomolecular condensates in plant germline differentiation (GX23-07969X)

important for differentiation of plant germline. We showed that P-bodies change understanding of gene regulation in plant germline, and proposed technological developments......

Cell biology

  • 2023 - 2027
    • •
  • 49 730 tis. Kč
    • •
  • 49 730 tis. Kč
    • •
  • GA ČR
Project

Mature fast, die young, but what about germ cells? Germline development and aging in the turquoise killifish - naturally short-lived vertebrate. (GN22-01781O)

and nonautonomous mechanism of germline aging and possibilities of preserving their viability mechanisms of germline aging, representing a milestone for senescent phenotype modelling......

Fishery

  • 2022 - 2025
    • •
  • 4 561 tis. Kč
    • •
  • 4 561 tis. Kč
    • •
  • GA ČR
Project

Mechanisms of parasitic RNA propagation and elimination in male germline studied on economically important viroid species. (GC18-10515J)

The haploid male germline of higher plants plays a vital role in plant fertility and crop production through the generation and transport of male gametes, double fertilization, seed production and finally through effective mechanisms elimina...

Genetics and heredity (medical genetics to be 3)

  • 2018 - 2021
    • •
  • 11 036 tis. Kč
    • •
  • 10 556 tis. Kč
    • •
  • GA ČR
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