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18 (0,086s) •

Project

Glycolipid A mimetics ? its chemo-enzymatic synthesis and immunological testing (OC D13.50)

New precursors of glycolipid A based on chitooligomers and aminosaccharides will be prepared using chemoenzymatic methods. New derivatives of glycolipid A will be tested for the imunogenicity and toxicity. Expected results - glycomimetics us...

CE - Biochemie

  • 2002 - 2003
    • •
  • 1 131 tis. Kč
    • •
  • 726 tis. Kč
    • •
  • MŠMT
Project

Glycolipid A mimetics ? its chemo-enzymatic synthesis and immunological testing (1P04OCD13.50)

New precursors of glycolipid A based on chitooligomers and aminosaccharides will be prepared using chemoenzymatic methods. New derivatives of glycolipid A will be tested for the imunogenicity and toxicity. Expected results - glycomimetics us...

CE - Biochemie

  • 2004 - 2004
    • •
  • 530 tis. Kč
    • •
  • 400 tis. Kč
    • •
  • MŠMT
Project

Enzymatic synthesis of multivalent glycoconjugates of natural and biologically active compounds. (LD13042)

The aim of the project is an elaboration of the methods of selective enzymatic glycosylation of multivalent glycomimetics (based on the thiourea-linked glycosides) and methodics of enzymatic glycosylation of the phenolic compounds. For g...

CE - Biochemie

  • 2013 - 2015
    • •
  • 1 442 tis. Kč
    • •
  • 1 442 tis. Kč
    • •
  • MŠMT
Project

Targeted glyco-nanomaterials for diagnosis and therapy of cancer (LTC19038)

Nanomaterials will be prepared that carry glycomimetics for specific inhibition of galectins, which are overproduced in selected cancer cell lines, and for active targeting of cancer cells through binding galectins. The prepared glyco-nanoma...

Biochemistry and molecular biology

  • 2019 - 2022
    • •
  • 4 946 tis. Kč
    • •
  • 4 946 tis. Kč
    • •
  • MŠMT
Project

New Enzymes and Selective Methods for Glycosidase-Catalysed Synthesis of Bioactive Glycosides and Glycomimetics (OC D25.002)

New enzymes for synthesis of oligoglycosides will be screened and characterized, especially a/b N-acetylmannosaminidase which is not known yet, enzyme library will be created. Novel methods for enzymatic synthesis of bioactive glycosides will be deve...

CE - Biochemie

  • 2002 - 2006
    • •
  • 2 636 tis. Kč
    • •
  • 1 726 tis. Kč
    • •
  • MŠMT
Project

Mono- and multivalent inhibitors of galectin-8 in tumour-associated (lymph)angiogenesis (GF25-16301K)

. Nature-like oligosaccharide epitopes and/or glycomimetics will be prepared...

Medicinal chemistry

  • 2025 - 2028
    • •
  • 6 480 tis. Kč
    • •
  • 6 480 tis. Kč
    • •
  • GA ČR
Project

Advanced glycomimetics in neurodegeneration research (GlycoDrug) (8X25048)

GlycoDrug project aims to develop new compound(s), which could bring a breakthrough in the treatment of Alzheimer's disease. The overall goal of the Croatian-Czech-Austrian GlycoDrug project is to conduct complex biological testing of the experimenta...

Pharmacology and pharmacy

  • 2025 - 2027
    • •
  • 247 tis. Kč
    • •
  • 247 tis. Kč
    • •
  • MŠMT
Project

Multidisciplinary Approach to Drug Design - Inhibition of Carbohydrate Acting Proteins (LH13055)

The main goal of the project is to contribute to development of strategy to design glycomimetics based inhibitors. Selected lectins and glycosyltransferase connected with infection and cancer diseases will be used as model proteins, which wi...

CE - Biochemie

  • 2013 - 2015
    • •
  • 1 379 tis. Kč
    • •
  • 1 379 tis. Kč
    • •
  • MŠMT
Project

Study of proteins from pathogens involved in host organism recognition (GA13-25401S)

a rational design of glycomimetics, which may inhibit a pathogen attachment to the cell...

CE - Biochemie

  • 2013 - 2017
    • •
  • 8 986 tis. Kč
    • •
  • 8 986 tis. Kč
    • •
  • GA ČR
Project

Design of Carbohydrates and Glycomimetics as Antibacterial and Antiviral Drugs (ME08008)

The goals and expected results of the proposed project are directed to the field of studies on lectins from pathogens that are involved in the host cell recognition and binding, which may further result in invasion. In the first period of the researc...

CE - Biochemie

  • 2008 - 2012
    • •
  • 3 485 tis. Kč
    • •
  • 2 375 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 18