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23 (0,072s) •

Project

Combinatorial chemistry in design of novel modulators of glycosidases function (OC D16.001)

-molecular weight inhibitors of glycosidases. The mimetics represent more effective and specific alternative to natural glycosidases inhibitors of saccharidic type. The mechanism o, f interaction of the novel inhibitors with the

CE - Biochemie

  • 2002 - 2004
    • •
  • 1 509 tis. Kč
    • •
  • 1 006 tis. Kč
    • •
  • MŠMT
Project

Kinetic profiling of glycosidases for synthesis of glycoconjugates (7AMB13FR014)

Synthetic glycoconjugates are attractive: i. as new immunostimulaing adjuvans with a potential in e.g. future anticancer therapy and, ii. in tuberculosis research due to their presence in mycobacterial cell walls. The aim of this project is to suppor...

CE - Biochemie

  • 2013 - 2014
    • •
  • 108 tis. Kč
    • •
  • 108 tis. Kč
    • •
  • MŠMT
Project

Library of engineered glycosidases for the preparation of bioactive glycans (LTC20072)

The aim of this project is to construct a toolbox of genetically modified glycosidases with desired catalytic properties, in particular enhanced synthetic capability, enhanced regioselectivity and/ or substrate specificity, and to use these ...

Biochemistry and molecular biology

  • 2020 - 2023
    • •
  • 3 997 tis. Kč
    • •
  • 3 997 tis. Kč
    • •
  • MŠMT
Project

New Enzymes and Selective Methods for Glycosidase-Catalysed Synthesis of Bioactive Glycosides and Glycomimetics (OC D25.002)

, ill be used as targets for enzymatic glycosylation.New synthetic glycosidase with glycosidases and target proteins (receptors). As target structures ligands for the NKR-P1......

CE - Biochemie

  • 2002 - 2006
    • •
  • 2 636 tis. Kč
    • •
  • 1 726 tis. Kč
    • •
  • MŠMT
Project

Enzymatic synthesis of multivalent glycoconjugates of natural and biologically active compounds. (LD13042)

partners) and for glycosylation of polyphenolic compounds new enzymes - glycosidases of polyphenolic compounds will be prepared using new glycosidases. Structures of the new......

CE - Biochemie

  • 2013 - 2015
    • •
  • 1 442 tis. Kč
    • •
  • 1 442 tis. Kč
    • •
  • MŠMT
Project

Galectins as biomarkers of colorectal cancer (LTC19035)

This project is focused on the evolution of chemoenzymatic synthesis of complex oligosaccharide ligands employing microbial glycosidases aiming at the design of new type of biosensor based on highly selective and specific interaction betwee...

Biochemistry and molecular biology

  • 2019 - 2022
    • •
  • 4 421 tis. Kč
    • •
  • 4 421 tis. Kč
    • •
  • MŠMT
Project

Stereoselective Synthesis of C-iminodisaccharides (GA203/03/0497)

Monosaccharide mimics such as iminosaccharides are potent inhibitors of glycosidases or glycosyl-transferases. Consequently, they can be potential antiviral, antibacterial, antimetastatic or immuno-stimulatory agents. However, they often inh...

CC - Organická chemie

  • 2003 - 2005
    • •
  • 1 889 tis. Kč
    • •
  • 869 tis. Kč
    • •
  • GA ČR
Project

Neutral oligosaccharides of human milk as ligands of galectins (GA20-00215S)

recombinant glycosidases. Their synthetic capability will be enhanced by site-directed...

Biochemistry and molecular biology

  • 2020 - 2023
    • •
  • 5 676 tis. Kč
    • •
  • 5 676 tis. Kč
    • •
  • GA ČR
Project

Glykosidases in fungi and their biochemical and taxonomic evaluation (IAA6020605)

and the strains selected will be used for the production of the respective glycosidases...

EE - Mikrobiologie, virologie

  • 1996 - 1998
    • •
  • 1 509 tis. Kč
    • •
  • 892 tis. Kč
    • •
  • AV ČR
Project

Rational synthesis of novel glycosidase inhibitors with antiviral and anticancer activity derived from sugar nitrogen analogues (GA203/96/0308)

Piperidine and pyrrolidine analogues of sugars are important glycosylation inhibitors, exhibiting notable biological effects, e.g. antiviral and anticancer activity. The aim of this project concerns development of novel methods for preparation of the...

CC - Organická chemie

  • 1996 - 1998
    • •
  • 1 803 tis. Kč
    • •
  • 1 041 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 23