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39 (0,219s) •

Project

Pyramidalization of the glycosidic nitrogen in nucleic acids; linking the structural phenomenon with chemistry of N-glycosidic bond cleavage (GA13-27676S)

We propose theoretical research of nucleic acids focused on pyramidalization of the glycosidic nitrogen and its role in chemistry of N-glycosidic bond cleavage in 8-oxoguanosine during base excision with the hOGG1 DNA repair enzyme....

CF - Fyzikální chemie a teoretická chemie

  • 2013 - 2017
    • •
  • 3 632 tis. Kč
    • •
  • 3 632 tis. Kč
    • •
  • GA ČR
Project

Novel Biocatalysts for the Production of Glycosides (7E11011)

This project aims to develop novel biocatalysts for the production of glycosides (NOVOSIDES). Glycosylated compounds have a wide range of applications, but very few enzymes are able to glycosylate small organic molecules cost-efficiently,

CE - Biochemie

  • 2011 - 2014
    • •
  • 3 659 tis. Kč
    • •
  • 3 659 tis. Kč
    • •
  • MŠMT
Project

Enzymatic synthesis of bioactive glycosides (OC 170)

development of methodoly of application of glykosylazides as donors for transglykosilation reactions with glykosidazes....

CE - Biochemie

  • 2007 - 2007
    • •
  • 132 tis. Kč
    • •
  • 132 tis. Kč
    • •
  • MŠMT
Project

New enzymes and methods for chemoenzymatic synthesis of bioactive glycosides (GA203/01/1018)

Novel methods for enzymatic synthesis of bioactive glycosides based on aminosugars will be developed. New reaction conditions will be tested in enzymatic glycosylation to improve effectiveness of these reactions. New enzymes for synthesis of...

CE - Biochemie

  • 2001 - 2003
    • •
  • 6 664 tis. Kč
    • •
  • 3 794 tis. Kč
    • •
  • GA ČR
Project

New Pd-catalyzed modular approach to non-hydrolyzable vectors for transfection systems (GPP207/12/P713)

of the glycosidic bond. To address the issue that oligosaccharides are prone to enzymatic is a novel versatile Pd-catalyzed approach to the synthesis of various C-glycosides and C to non-hydrolysable vectors for trasfection systems...

CC - Organická chemie

  • 2012 - 2014
    • •
  • 2 313 tis. Kč
    • •
  • 2 313 tis. Kč
    • •
  • GA ČR
Project

New ‚ ‘masked’ fusarium mycotoxins occurring in malt and beer, explaining the ways of origination and suggesting strategies for their mitigation (8E18B045)

The aim of the project is realization of integrated research in the area of ‘masked’ Fusarium mycotoxins, i.e. conjugates with mono-/oligoglycosides, within the barley-malt-beer production chain. Attention will be paid mainly to the unambiguous chara...

Agricultural biotechnology and food biotechnology

  • 2018 - 2020
    • •
  • 978 tis. Kč
    • •
  • 978 tis. Kč
    • •
  • MŠMT
Project

Glycosides and Glycuronates of Biologically Active Alcohols as Potential Insect Pest Management Agents (GA203/02/0166)

The key aims of this project are summarized in the following brief outline: Designing of convenient general synthetic procedures of preparation of alkyl glycosides (glucosides, galactosides, mannosides etc.), based on selection of both, race...

CC - Organická chemie

  • 2002 - 2004
    • •
  • 8 902 tis. Kč
    • •
  • 3 225 tis. Kč
    • •
  • GA ČR
Project

Impact of the digestion and absorption processes on the final biological activity of diet phytonutrients real health added-value (8X20023)

and glycosides (punicalagin, elagic acid, quercetin, resveratrol, apigenin, capsaicin from the group of polyphenols, alkaloids and glycosides (punicalagin, elagic acid......

Cell biology

  • 2020 - 2022
    • •
  • 203 tis. Kč
    • •
  • 203 tis. Kč
    • •
  • MŠMT
Project

Synthesis of immunoactive glycosides by beta-N-acetylhexosaminidases (GP203/09/P024)

of disaccharides will be prepared from glycosides bearing various charged groups at C-6. Their ability to accept the modified glycosides as substrates will be predicted by molecular......

CE - Biochemie

  • 2009 - 2011
    • •
  • 987 tis. Kč
    • •
  • 987 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanism of interaction between the H4-H5 loop of Na+/K+-ATPase and the binding site for cardiac glycosides (IAA7011801)

Na+/K+-ATPase is transporting enzyme for Na+ and K+ across the plasma membrane which is also called a receptor for cardioactive glycosides. The binding site for cardiac glycosides was revealed to be far away from the binding site fo...

BO - Biofyzika

  • 1998 - 2000
    • •
  • 1 852 tis. Kč
    • •
  • 1 075 tis. Kč
    • •
  • AV ČR
  • 1 - 10 out of 39