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9 (0,064s) •

Project

Glycosphingolipids - Tumor Associated Markers (GA302/94/1294)

9H - 9

  • 1994 - 1996
    • •
  • 1 032 tis. Kč
    • •
  • 1 502 tis. Kč
    • •
  • GA ČR
Project

Pathobiochemistry of glycosphingolipids in some inherited lysosomal diseases (Niemann-Pick type C, Fabry and Schindler disease) (GA303/93/0651)

CE - Biochemie

  • 1993 - 1994
    • •
  • 0 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • GA ČR
Project

The role of glycofphingolipids, immune mechanismus and inflamation in the pathogenesis of experimental and clinical cholestasis (NR8079)

To determine, by immunohistochemistry, glycosphingolipid localisation in the canalicular and sinusoidal membranes and localisation transfer to the sinusoids both in induced experimental cholestasis and in human biopsy and autopsy speciments....

FE - Ostatní obory vnitřního lékařství

  • 2004 - 2006
    • •
  • 3 501 tis. Kč
    • •
  • 2 932 tis. Kč
    • •
  • MZ
Project

Glycosphingolipids and their metabolic pathways as potential colon cancer biomarkers (NU21-03-00421)

of specific glycosphingolipid (GSL) species, which indicates a possibility to use GSLs...

Oncology

  • 2021 - 2025
    • •
  • 14 495 tis. Kč
    • •
  • 14 448 tis. Kč
    • •
  • MZ
Project

Use of tandem mass spectrometry of glycosphinoglipids for diagnosis of lysosomal storage diseases and for monitoring of treatment in Fabry disease. (NR8167)

Inherited lysosomal storage disorders are characterized by accumulation of different substrates due to the deficiency of specific lysosomal hydrolases, defects of protein activators or transport mechanism. In Fabry disease, deficiency of ?-galactosid...

FG - Pediatrie

  • 2004 - 2006
    • •
  • 2 008 tis. Kč
    • •
  • 1 821 tis. Kč
    • •
  • MZ
Project

Characterization of the first mouse model of mucopolysaccharidosis type IIIC (NT13122)

The goal of the project is to characterize structural, biochemical and transcriptional changes in knock-out mouse model of hereditary lysosomal disorder, mucopolysaccharidosis type IIIC (MPS IIIC), which was developed as a joint effort with Prof Pshe...

FG - Pediatrie

  • 2012 - 2015
    • •
  • 5 093 tis. Kč
    • •
  • 5 092 tis. Kč
    • •
  • MZ
Project

Mapping galectin-ganglioside networks on complex model membrane systems (GA25-15346S)

Galectins, a family of glycan-binding proteins, play pivotal roles in diverse physiological and pathological processes, including tumour progression and resistance to anticancer treatments. In this research program, we aim to elucidate the existence ...

Physical chemistry

  • 2025 - 2027
    • •
  • 9 219 tis. Kč
    • •
  • 8 841 tis. Kč
    • •
  • GA ČR
Project

ORMDL sphingolipid biosynthesis regulator 2 in immunoreceptor activation (GA17-20915S)

production of cytokines, metabolism of eicosanoids and glycosphingolipids, unfolded...

EC - Imunologie

  • 2017 - 2021
    • •
  • 8 217 tis. Kč
    • •
  • 7 671 tis. Kč
    • •
  • GA ČR
Project

Evaluation of new biomarkers of Fabry disease in selected groups of patients in the Czech Republic (NU21-08-00324)

glycosphingolipid is globotriaosylceramide (Gb3Cer). This and other metabolites excessively...

Analytical chemistry

  • 2021 - 2025
    • •
  • 11 114 tis. Kč
    • •
  • 11 114 tis. Kč
    • •
  • MZ
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