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4 823 (0,131s) •

Project

Interactions of stable adenosine receptor agonists and granulocyte colony-stimulating factor (G-CSF) in hematopoiesis (GA305/06/0015)

will be directed  to employing combined action of granulocyte colony-stimulating factor demonstrated that stimulation of adenosine membrane receptors with their agonists modulates in the sense of stim...

FD - Onkologie a hematologie

  • 2006 - 2008
    • •
  • 3 157 tis. Kč
    • •
  • 3 157 tis. Kč
    • •
  • GA ČR
Project

Enhancement of G-CSF action by adenosine signalling testing of its potential clinical use in murine models (GA306/99/0027)

Previous original findings of the applicants have demonstrated synergistic effects of granulocyte colony-stimulating factor (G-CSF) and drugs elevating extracellular adenosine (dipyridamole, AMP). Potentiation of p...

ED - Fyziologie

  • 1999 - 2001
    • •
  • 2 397 tis. Kč
    • •
  • 1 821 tis. Kč
    • •
  • GA ČR
Project

The role of adhesion molecules and cytokines in hematopoirtic stem cell mobilization in healthy donors (NR9268)

1. Analysis of differences in secretion of chemokines playing role in CD34+ mobilization mechanism before and during granulocyte- colony stimulating factor administration using ELISA methods and multiplex analysis....

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 1 981 tis. Kč
    • •
  • 1 981 tis. Kč
    • •
  • MZ
Project

The role of signalling through adenosine receptors and its interaction with G-CSF in regulation of haematopoiesis (GP305/03/D050)

) and A3 adenosine receptors (IB-MECA) will be studied. Colony-stimulating activity and co-stimulating activity of blood serum will be assayed using a bioassay for haematopoietic progenitor cell for granulocytes an...

FR - Farmakologie a lékárnická chemie

  • 2003 - 2006
    • •
  • 677 tis. Kč
    • •
  • 677 tis. Kč
    • •
  • GA ČR
Project

Reprogramming the fate of hematopoietic cells in cyprinid fish (GA24-10486S)

cells and it is precisely regulated by a variety of extrinsic and intrinsic factors expression of single or multiple transcription factors. Here we have employed with transcription factor binding site enrichment analysis w...

Cell biology

  • 2024 - 2026
    • •
  • 9 942 tis. Kč
    • •
  • 8 964 tis. Kč
    • •
  • GA ČR
Project

The Ribosomal Gene Transcription in Transformed Blood Cells Expression and Interaction of the Regulatory Proteins and their Posttranslational Modifications. Th (IZ4073)

Expression and function studies of transcription factors invelved in ribozomal gene transcription performed on a set of leukemic cell lines,in vitro stimulated lamphocytes and blood cells of leukemic patients. Characterization of th...

FD - Onkologie a hematologie

  • 1997 - 1999
    • •
  • 5 401 tis. Kč
    • •
  • 3 608 tis. Kč
    • •
  • MZ
Project

ROLE OF CYTOKINE PRIMING IN AZACITIDINE-MEDIATED LEUKEMIA STEM CELL DIFFERENTIATION IN THERAPY OF PROGRESSING MYELODYSPLASIA (GA18-01687S)

and milder cytotoxic effects on myeloid progenitor cells. Cytokines including granulocyte-colony stimulating factor (G-CSF) added prior DNMTi improved AZA-mediated blood cell......

Oncology

  • 2018 - 2020
    • •
  • 10 226 tis. Kč
    • •
  • 10 082 tis. Kč
    • •
  • GA ČR
Project

Cultivation and expansion of hematopoietic stem cells in vitro - which cell selection method and culture conditions should be used? (NC7493)

To optimize immunomagnetic selection of hematopoietic stem cells, for maximum achievable purity, yield. and recovery parameters. To find the best combination of cytokines which would allow maximum expansion of granulocytic progenitor cells i...

FD - Onkologie a hematologie

  • 2003 - 2003
    • •
  • 414 tis. Kč
    • •
  • 414 tis. Kč
    • •
  • MZ
Project

Possibilities of the enhancement of G-CSF efficacy under conditions of radiation-induced myelosuppression by the extracellular adenosine receptor action (GA306/96/1721)

of granolocyte colony-stimulating factor (G-CSF). The efficacy of the combined action...

BO - Biofyzika

  • 1996 - 1998
    • •
  • 2 017 tis. Kč
    • •
  • 1 423 tis. Kč
    • •
  • GA ČR
Project

Methylation of histone H3 as a prognostic marker of chronic myeloid leukemia remission (1QS500040508)

granulocytes. Monomethylated and especially dimethylated H3K9 are, however, present in granulocytes of patients with chronic myeloid leukemia (CML) without HP1 proteins. We. The exposure of methylated H3K9 in CML granulocytes

FD - Onkologie a hematologie

  • 2005 - 2009
    • •
  • 6 365 tis. Kč
    • •
  • 6 365 tis. Kč
    • •
  • AV ČR
  • 1 - 10 out of 4 823