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2 862 (0,091s) •

Project

Elucidating the etiopathogenesis of a growth disorder in children with clinically diagnosed growth hormone deficiency using modern genetic methods as a way to optimize the diagnostics (NU22J-07-00014)

Growth hormone (GH) plays a fundamental role in short stature pathogenesis. Children with growth hormone deficiency (GHD) form a substantial part of individuals with short stature treated with GH. The diag...

Paediatrics

  • 2022 - 2025
    • •
  • 6 888 tis. Kč
    • •
  • 6 888 tis. Kč
    • •
  • MZ
Project

Physiological role of ghrelin; the importance for clinical medicine. (NB7099)

in acromegaly and growth hormone deficiency in relationship with other parametrsGhrelin is a new peptide hormone serving as a regulator of growth hormone secretion, food intake and nutritionalsta...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2002 - 2005
    • •
  • 2 901 tis. Kč
    • •
  • 2 723 tis. Kč
    • •
  • MZ
Project

Binding proteins of IGF in hypopituitary patients treated with growth hormone. (NB5458)

IGF I binding proteins, Western Blotting, fragmentation, therapy with growth hormone. The examination of IGF I binding proteins including their low and high molecular forms and proteolytic fragments will contribute to the improvemen...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1999 - 2001
    • •
  • 1 914 tis. Kč
    • •
  • 1 914 tis. Kč
    • •
  • MZ
Project

ESTABLISHING GENETIC DIAGNOSIS IN CHILDREN WITH GROWTH DISORDERS USING NEXT GENERATION SEQUENCING METHODS - A PATHWAY TOWARDS INDIVIDUALIZED THERAPY (NV16-31211A)

) idiopathic short stature, (3) intrauterine growth retardation followed by postnatal growth failure and with (4) idiopathic growth hormone deficiency. RecognitionHuman growth is strongly genetica...

FG - Pediatrie

  • 2016 - 2019
    • •
  • 10 673 tis. Kč
    • •
  • 10 673 tis. Kč
    • •
  • MZ
Project

Influence of Human Growth Hormone Treatment Together with Glutamine Supplementation on Immune and Metabolic Status of Critically Ill (NR8230)

The study is designed to evaluate the efficacy of the low-dose i.v. growth hormone treatment together with glutamine supplementation in the critically ill. We presume that glutamine supplementation is able to prevent growth...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2007
    • •
  • 1 774 tis. Kč
    • •
  • 1 509 tis. Kč
    • •
  • MZ
Project

Overall evaluation of selenium deficiency in population of the Czech Republic based on its specification in individual regions (GA311/99/0832)

and material for elimination of its deficiency in population of CR will be prepared. Serum elimination of Se deficiency. Substantial improvement of health status could be expected as the result of Se deficiency elimination...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1999 - 2001
    • •
  • 2 050 tis. Kč
    • •
  • 2 002 tis. Kč
    • •
  • GA ČR
Project

Improvement of the diagnostics of disorders of growth hormone secretion with the follow- up of growth hormone binding protein and IGF-binding protein 3 (IZ2344)

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1994 - 1997
    • •
  • 589 tis. Kč
    • •
  • 706 tis. Kč
    • •
  • MZ
Project

Effect of growth hormone and glutamine on protein metabolism in isolated skeletal muscle. (NB7611)

Possibilities of influencing protein catabolism by treatment with growth hormone and glutamine will be studied using the method of incubation of isolated rat skeletal muscle. Major parameters of protein metabolism will be assessed u...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2003 - 2005
    • •
  • 934 tis. Kč
    • •
  • 931 tis. Kč
    • •
  • MZ
Project

Whole transcriptome study of transgenic barley with altered cytokinin homeostasis (GA14-12355S)

, which is the fourth most important crop worldwide. Modulation of hormonal status represents an incredible tools how to influence plant´s growth and development. Cytokinins are hormones playing key role all through the pla...

EB - Genetika a molekulární biologie

  • 2014 - 2016
    • •
  • 6 568 tis. Kč
    • •
  • 6 568 tis. Kč
    • •
  • GA ČR
Project

Hormonal control of insect defence system (GA17-03253S)

The proposed project is focused on a functional study of adipokinetic hormone (AKH) and its role in infections elicited by several pathogens (nematodes, bacteria-deficient, AKH receptor deficient etc.), and mutants in genes...

ED - Fyziologie

  • 2017 - 2019
    • •
  • 8 985 tis. Kč
    • •
  • 8 502 tis. Kč
    • •
  • GA ČR
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