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16 274 (0,227s) •

Project

Structure-functional Relationships of Haloalkane Dehalogenases (GAP207/12/0775)

of structure-function relationships of haloalkane dehalogenases and related a/b-hydrolases.Haloalkane dehalogenases (EC 3.8.1.5) are microbial enzymes with catalytic haloalkane dehal...

CD - Makromolekulární chemie

  • 2012 - 2016
    • •
  • 12 225 tis. Kč
    • •
  • 12 225 tis. Kč
    • •
  • GA ČR
Project

Rational re-design of microbial enzymes involved in degradation of toxic organic pollutants. (ME 276)

The main objective of the project is the investigation of structure-function aliphatic hydrocarbons. The structures of the proteins from the family of haloalkane dehalogenases will be rationaly modified us...

EB - Genetika a molekulární biologie

  • 1998 - 2002
    • •
  • 3 260 tis. Kč
    • •
  • 1 160 tis. Kč
    • •
  • MŠMT
Project

Exploring the acquisition of novel protein functions within haloalkane dehalogenase family (GA22-09853S)

that will investigate the molecular structures of model enzymes from haloalkane dehalogenase family systems and can be given non-natural catalytic functions by protein engineering the structural diversity...

Arts, Art history

  • 2022 - 2024
    • •
  • 13 757 tis. Kč
    • •
  • 13 677 tis. Kč
    • •
  • GA ČR
Project

Structural basis for the emergence of new enzymatic activities (GA16-24223S)

structural insights into catalysis of resurrected ancestor of two functionally distinct enzymes, eukaryotic haloalkane dehalogenase from Strongylocentrotus purpuratusUnderstanding of the emergence of new enzymatic...

CE - Biochemie

  • 2016 - 2018
    • •
  • 6 800 tis. Kč
    • •
  • 6 672 tis. Kč
    • •
  • GA ČR
Project

Study of the molecular mechanisms of biodegradation reactions - construction of QSBR models and protein engineering of haloalkane dehalogenases (GA203/97/P149)

. Modification in the enzymes haloalkane dehalogenases will be proposed using thecomputerThe project is focused on biodegradation of the organic compounds by microorganisms. Fundamental mechanisms of the biodegradation reaction and ...

CE - Biochemie

  • 1997 - 1999
    • •
  • 643 tis. Kč
    • •
  • 493 tis. Kč
    • •
  • GA ČR
Project

Enzyme hydration and flexibility studied by advanced structural and biophysical methods (GA17-24321S)

An integrated view of protein structure, solvation, dynamics, and function is emerging where internal protein motions are closely linked to enzyme catalysis. The main objective of this project is to investigate connection between hy...

CE - Biochemie

  • 2017 - 2019
    • •
  • 9 834 tis. Kč
    • •
  • 9 578 tis. Kč
    • •
  • GA ČR
Project

Evolution of substrate specificity in enzymes acting on xenobiotic compounds (IAA401630901)

, haloalkane dehalogenases, is suitable for this purpose since these enzymes act of the substrate specificity of modern haloalkane dehalogenases and their comparison. The ultimate goal will be estimation of the lev...

CE - Biochemie

  • 2009 - 2013
    • •
  • 5 600 tis. Kč
    • •
  • 5 600 tis. Kč
    • •
  • AV ČR
Project

ENYZM-MIX, Enzyme based detoxification formulations (OSVTUO2007006)

of the research work will be devoted to a stabilisation of the haloalkane dehalogenases being lyophilised for a long-term storage. Durability of the three-dimensional structure......

KA - Vojenství

  • 2007 - 2009
    • •
  • 8 000 tis. Kč
    • •
  • 8 000 tis. Kč
    • •
  • MO
Project

Analysis of microbial communities from different aquatic habitats specific transcriptomics in relation to pollution by volatile organic compounds (GAP504/10/0137)

haloalkane dehalogenases (HADs) and epoxide hydrolases (EHs), which are key enzymes...

EH - Ekologie – společenstva

  • 2010 - 2012
    • •
  • 2 289 tis. Kč
    • •
  • 2 289 tis. Kč
    • •
  • GA ČR
Project

Biosensors for determination of nerve agents and yperites using recombinant proteins and nanotechnology (OVUOFVZ200807)

The proposed project is aimed at construction of enzyme based biosensors with immobilized ether cholinesterase and/or dehalogenase for detection of nerve agents and yperite usány highly innovative nanotechnologies.......

FP - Ostatní lékařské obory

  • 2008 - 2011
    • •
  • 5 292 tis. Kč
    • •
  • 4 609 tis. Kč
    • •
  • MO
  • 1 - 10 out of 16 274