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Self-renewal of hematopoietic stem cells in regenerating hematopoiesis. (GA14-25515S)
Long-lasting regeneration of hematopoietic tissue is possible only from hematopoietic stem cells (HSCs). Engraftment of transplanted bone marrow is highly facilitated by damage to the host HSCs. This is explained b...
FD - Onkologie a hematologie
- 2014 - 2016 •
- 8 812 tis. Kč •
- 8 812 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2014 - 31. 12. 2016
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Expression of cytochromes P450 in hematopoietic stem cells. (NL7295)
Expression of cytochromes P450 in hematopoietic stem cells obtained by separetion from petipheral blood will be follewed by Northern blogging, real-time PCR, Western blotting and by determination of specific enzyme activiti...
FR - Farmakologie a lékárnická chemie
- 2002 - 2004 •
- 1 528 tis. Kč •
- 1 212 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2002 - 1. 1. 2004
Uznané náklady
Podpora ze státního rozpočtu (79%)
Poskytovatel: Ministerstvo zdravotnictví
Mechanisms regulating normal and leukemic hematopoietic stem cells Deciphering the role of the beta-catenin/Tcf signaling pathway (GA17-02177S)
Hematopoietic stem cells (HSC) are a rare population of cells in bone marrow with self-renewal properties, and accordingly are able to sustain blood cell production throughout life. Their counterpart in ma...
FD - Onkologie a hematologie
- 2017 - 2021 •
- 6 927 tis. Kč •
- 6 213 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2017 - 31. 12. 2021
Uznané náklady
Podpora ze státního rozpočtu (90%)
Poskytovatel: Grantová agentura České republiky
Cultivation and expansion of hematopoietic stem cells in vitro - which cell selection method and culture conditions should be used? (NC7493)
To optimize immunomagnetic selection of hematopoietic stem cells, for maximum achievable purity, yield. and recovery parameters. To find the best combination of cytokines which would allow maximum expansion of granulocytic ...
FD - Onkologie a hematologie
- 2003 - 2003 •
- 414 tis. Kč •
- 414 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2003 - 1. 1. 2003
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Development of gene-editing tools for correction and validation of mutations cuasative of monogenic hematopoietic disorders (GJ17-04941Y)
pluripotent stem cells are then used in transplant as an unlimited source of hematopoietic hematopoietic cells represent a large group that manifest with a bone marrow failure curative therapy for these p...
FD - Onkologie a hematologie
- 2017 - 2021 •
- 5 538 tis. Kč •
- 5 538 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2017 - 31. 12. 2021
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Subpopulations of CD34 cells in peripheral blood stem cells graft and their role for engraftment in autologous and related-donor allogeneic transplantation of hematopoiesis in the treatment of cancer (NR8003)
Hematopoietic stem cells fully reconstitute the function of bone marrow after transplantation of hematopoiesis. They can be clinically defined as cells expressing CD34+ antigen. CD34+ cell population is no...
FD - Onkologie a hematologie
- 2004 - 2006 •
- 1 454 tis. Kč •
- 1 359 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2004 - 1. 1. 2006
Uznané náklady
Podpora ze státního rozpočtu (93%)
Poskytovatel: Ministerstvo zdravotnictví
Quantitative real-time PCR monitoring of six herpesviruses in patients after allogeneic hematopoietic stem cell transplantation. (NJ7459)
Using real-time PCR quantification, we will investigate incidence, risk factors and prognosis of herpesvirus infection in a cohort of pacients after hematopoiatic stem cell transplantation.......
FN - Epidemiologie, infekční nemoci a klinická imunologie
- 2003 - 2005 •
- 4 465 tis. Kč •
- 4 420 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2003 - 1. 1. 2005
Uznané náklady
Podpora ze státního rozpočtu (99%)
Poskytovatel: Ministerstvo zdravotnictví
Regulation of hematopoietic stem cell differentiation by chromatin remodeling SWI/SNF2 ATPase Smarca5 (Snf2h) in mouse. (GAP305/12/1033)
) mouse model and our preliminary data indicate that in hematopoietic cells its deletion leads to block of stem cell differentiation and lineage commitment; stem cells for hematopoietic d...
EB - Genetika a molekulární biologie
- 2012 - 2016 •
- 14 550 tis. Kč •
- 14 550 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2012 - 31. 12. 2016
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Effects of chronic inflammation on hematopoietic stem cells and leukemia development (GA20-03380S)
inflammation has on hematopoietic stem cells (HSCs), the mechanisms mediating the long-term impact, and whether these conditions predispose to hematopoietic disorders is poorly......
Cell biology
- 2020 - 2022 •
- 9 360 tis. Kč •
- 9 231 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2020 - 31. 12. 2022
Uznané náklady
Podpora ze státního rozpočtu (99%)
Poskytovatel: Grantová agentura České republiky
Safer biotechnology of the allogeneic hematopoietic stem cells in solid and hematological cancer as an adoptive immunotherapy (2B06058)
The aim of the proposed project is an improvement of adoptive immunotherapy using an experimental allogeneic hematopoietic stem cell transplantation. It is focused on pre-clinical research in safer biotechnology of allogene...
EC - Imunologie
- 2006 - 2011 •
- 76 750 tis. Kč •
- 67 796 tis. Kč •
- MŠMT
Řešení projektu: 1. 7. 2006 - 30. 6. 2011
Uznané náklady
Podpora ze státního rozpočtu (88%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
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