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6 399 (0,128s) •

Project

Molecular mechanisms of intraprotein/interdomain signal transduction in model heme sensor proteins (GA15-19883S)

The heme-containing sensor proteins, a novel group of hemoproteins, are generally composed of two domains: a sensor domain (heme sensing or heme-based gas sensing) and a functional domain...

CE - Biochemie

  • 2015 - 2017
    • •
  • 4 677 tis. Kč
    • •
  • 4 677 tis. Kč
    • •
  • GA ČR
Project

Chlorophyll binding domain of cyanobacterial ferrochelatase role in chlorophyll biosynthesis and in accumulation of chlorophyll-protein complexes (GAP501/11/2197)

Ferrochelatase, the final enzyme of heme biosynthesis catalyzes insertion, ferrochelatase lies at the branch-point of heme/chlorophyll biosynthesis. Characteristic hydrophobic domain containing a chlorophyll-binding motif. ...

ED - Fyziologie

  • 2011 - 2015
    • •
  • 3 066 tis. Kč
    • •
  • 3 066 tis. Kč
    • •
  • GA ČR
Project

Prevention of antibiotic resistance by TARGEted Treatment of pneumonia in children (8F20011)

1)To develop an assay to specifically identify bacterial pathogens in a simple and sensitive way, applicable in LMIC, using LAMP 2) To clinically implement the MBS and LAMP-based detection in a hospital setting in Tanzania and to test the feasibility...

Biochemistry and molecular biology

  • 2020 - 2024
    • •
  • 6 438 tis. Kč
    • •
  • 6 438 tis. Kč
    • •
  • MŠMT
Project

Heme a putative master regulator in trypanosomatids (GA16-18699S)

Heme is one of the most important cofactor in extant organisms, constituting and leishmanias are not able to synthesize heme and thus belong to heme auxothrophs. In order to shed light on how they utilize heme acqu...

EB - Genetika a molekulární biologie

  • 2016 - 2018
    • •
  • 7 088 tis. Kč
    • •
  • 6 473 tis. Kč
    • •
  • GA ČR
Project

Structural basis for function within the family of nitric oxide synthases (GA303/05/0336)

The family of nitric oxide synthases (inducible-iNOS; endothelial-eNOS; neuronal-nNOS) combines the unique properties of heme- and flavin-containing proteins in one polypeptide chain to achieve the, production of a small, d...

CE - Biochemie

  • 2005 - 2007
    • •
  • 3 201 tis. Kč
    • •
  • 3 201 tis. Kč
    • •
  • GA ČR
Project

Cytochrome c maturation in cyanobacteria (IAB5020002)

photosynthesis and respiration, involves heme transport across the membrane and its covalent cyanobacterium Synechocystis sp. PCC 6803 indicate that two proteins CcsA and CcsB may play a central role in this process with CcsA bindi...

EB - Genetika a molekulární biologie

  • 2000 - 2002
    • •
  • 1 131 tis. Kč
    • •
  • 900 tis. Kč
    • •
  • AV ČR
Project

Ferrochelatase in cyanobacteria role of the hypothetical chlorophyll-binding (KJB5817301)

. In plants and cyanobacteria ferrochelatase lies at the branch-point of heme/chlorophyll the role of ferrochelatase in regulation of heme/chlorophyll biosynthesis in plants and cyanobacteria with homology to chlorophyll binding

EB - Genetika a molekulární biologie

  • 2003 - 2005
    • •
  • 1 256 tis. Kč
    • •
  • 966 tis. Kč
    • •
  • AV ČR
Project

Identification and localization of protein complexes involved in the regulation of chlorophyll biosynthesis (GAP501/10/1000)

Chlorophyll (Chl) and heme are produced via a common branched pathway that has to be tightly regulated as many tetrapyrroles are phototoxic and the demand for heme or Chl assembled into protein complexes and located in subc...

ED - Fyziologie

  • 2010 - 2013
    • •
  • 4 049 tis. Kč
    • •
  • 4 049 tis. Kč
    • •
  • GA ČR
Project

NEW POSSIBILITIES IN THERAPY OF HIV/AIDS DISEASE ROLE OF HEME OXYGENASE, BILIVERDIN REDUCTASE AND THE EFFECTS OF HEME ARGINATE ON REPLICATION AND REACTIVATION OF HIV-1 (NT14135)

/ To characterize redox state and heme metabolism in HIV+ patients, namely GSH, nitrate and hBVR of individual proteins; PCR and real-time RT-PCR - reverse transcription and reactivation......

EE - Mikrobiologie, virologie

  • 2013 - 2015
    • •
  • 6 216 tis. Kč
    • •
  • 6 084 tis. Kč
    • •
  • MZ
Project

Antiproliferative effects of bilirubin, heme metabolites, and heme oxygenase expression on colon and pancreatic cancer. (ME 849)

detailed study on the role of bilirubin metabolism in phatogenesis of colon and pancreatic cancer, basic research, database research...

FD - Onkologie a hematologie

  • 2006 - 2009
    • •
  • 2 890 tis. Kč
    • •
  • 2 770 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 6 399