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Project

Development of Medium-Scale Hepatocytes Bioreactors for Biomedical Studies A Step towards a Bioarteficial Liver (NL5885)

The development of medium-scale Hepatocyte bioreactor is expected to add a number of advantages in hepatocyte research and represent a step towards a bioartificial Liver.......

FR - Farmakologie a lékárnická chemie

  • 2000 - 2002
    • •
  • 2 813 tis. Kč
    • •
  • 2 813 tis. Kč
    • •
  • MZ
Project

Establishment and exploitation of human hepatocyte culture systems for the in vitro evaluation of drug metabolism (OC B15.40)

Establishment and exploitation of human hepatocyte culture systems for the in vitro evaluation of drug metabolism...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2002 - 2003
    • •
  • 1 848 tis. Kč
    • •
  • 1 271 tis. Kč
    • •
  • MŠMT
Project

Establishment and exploitation of human hepatocyte culture systems for the in vitro evaluation of drug metabolism (1P04OCB15.40)

Establishment and exploitation of human hepatocyte culture systems for the in vitro evaluation of drug metabolism...

FR - Farmakologie a lékárnická chemie

  • 2004 - 2004
    • •
  • 1 000 tis. Kč
    • •
  • 700 tis. Kč
    • •
  • MŠMT
Project

Some regulatory mechanismus in hepatotoxicity studies in isolated hepatocytes and hepatocytes bioreactor model (IZ4180)

Studies of some regulatory mechanism including nitric oxide and cytosolic calcium in hepatotoxicity.Research will be carred out in isolated hepatocytes and hepatocytes bioreactor model. Research will present an additional opportunit...

FR - Farmakologie a lékárnická chemie

  • 1997 - 1999
    • •
  • 2 539 tis. Kč
    • •
  • 2 539 tis. Kč
    • •
  • MZ
Project

Role of glucocorticoid hormones in the Aryl hydrocarbon receptor cellular signalling in human hepatocytes (MEB040908)

The aim of the project is to examine molecular mechanisms of interactions between signaling pathways of glucocorticoid receptor and aryl hydrocarbon receptor (AhR) in primary cultures of human hepatocytes and cancer cell lines.......

FR - Farmakologie a lékárnická chemie

  • 2009 - 2010
    • •
  • 124 tis. Kč
    • •
  • 124 tis. Kč
    • •
  • MŠMT
Project

Expression of ob gene and coding leptin production in hepatocytes of liver with steatossis. (NM8)

Expression of ob gene for leptin in hepatocyte of the liver with steatosis, including circulating leptinemia, has been studied for the first time. This model was proved only in adipocytes up to now. The patients with liver steatosis were fol...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1998 - 2000
    • •
  • 1 784 tis. Kč
    • •
  • 1 570 tis. Kč
    • •
  • MZ
Project

Study of some aspects on nitric oxide and nitric oxide synthase in hepatocytes regulation and pharmacological implications (GA305/00/1129)

Recently, it has been demonstrated that hepatocytes produce nitric oxide pathobiological aspects of endogenously induced- or exogenously delivered- NO on hepatocyte. Pharmacological intervention to modulate iNOS expression or NO pro...

FR - Farmakologie a lékárnická chemie

  • 2000 - 2002
    • •
  • 2 050 tis. Kč
    • •
  • 2 050 tis. Kč
    • •
  • GA ČR
Project

Primary cultures of hepatocytes as a model for studies of cytoprotectivity of selected natural substances (NL5267)

Primary cultures of human hepatocytes will be used to study cytoprotectivity of natural substances against intoxication by tetrachloromethane,tert.butylhydroperoxide,galactosemine,doxorubicin,tacrite,and iron and its complexws with anthacycl...

FR - Farmakologie a lékárnická chemie

  • 1999 - 2001
    • •
  • 872 tis. Kč
    • •
  • 872 tis. Kč
    • •
  • MZ
Project

Polarised cultures of hepatocytes and mesenchymal cells on the nanofiber membranes in the experimental bioreactor (GA304/07/1129)

Recent advances in preparation of nanofiber layers allow us to employ these layers as cell carriers in bioreactors. The placement of the hepatocyte cell culture and biliary hepatal circulation. Proposed project investigates polarized hep...

FJ - Chirurgie včetně transplantologie

  • 2007 - 2011
    • •
  • 8 783 tis. Kč
    • •
  • 8 783 tis. Kč
    • •
  • GA ČR
Project

Colchicinoids and 6-benzylaminpurine-type cytokines - their effect on expression of selected isoforms of cytochromes P450 in human liver cell cultures (GA303/99/P002)

hepatocytes. Colchicinoids exhibit cytoprotective effect on rat hepatocytes and an anti isoforms (CYP 1A2, 3A4, 2C9, 2D6, 2E1) in human hepatocytes cultured in the form fractions of human hepatocytes.......

CE - Biochemie

  • 1999 - 2001
    • •
  • 558 tis. Kč
    • •
  • 558 tis. Kč
    • •
  • GA ČR
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